Diethylaminomalonathydrochlorid

Diethyl aminomalonate hydrochloride Struktur
13433-00-6
CAS-Nr.
13433-00-6
Bezeichnung:
Diethylaminomalonathydrochlorid
Englisch Name:
Diethyl aminomalonate hydrochloride
Synonyma:
Diethyl 2-aminomalonate;DIETHYL 2-AMINOMALONATE HYDROCHLORIDE;Aminomalonamid;aminomalonate hydrochloride;diethyl 2-aminopropanedioate;AminomaL;onate HydrochL;Diethyl aminomalonat;Amoxapine Impurity 6;Amoxapine Impurity 2 HCl
CBNumber:
CB0325376
Summenformel:
C7H14ClNO4
Molgewicht:
211.64
MOL-Datei:
13433-00-6.mol

Diethylaminomalonathydrochlorid Eigenschaften

Schmelzpunkt:
165-170 °C (dec.)(lit.)
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
Chloroform, DMSO, Water
Aggregatzustand
Crystalline Powder
Farbe
White to slightly yellow
Wasserlöslichkeit
soluble
Sensitive 
Hygroscopic
BRN 
3568037
InChIKey
GLFVNTDRBTZJIY-UHFFFAOYSA-N
CAS Datenbank
13433-00-6(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36
WGK Germany  3
Hazard Note  Irritant
HS Code  29224995
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Diethylaminomalonathydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

white to slightly yellow crystalline powder

Verwenden

Diethyl aminomalonate hydrochloride is used as a pharmaceutical intermediate. Diethyl aminomalonate with formaldehyde generates an azomethine ylide which can undergo cycloadditions with 1,2-dipolarophiles to form pyrrolidines.

Synthese

A solution of 420.0 g of a mixture of diethyl hydroxyiminomalonate and diethyl acetoxyiminomalonate (together 2.0 mol) in 400 ml of ethyl acetate, 40.0 g of anhydrous magnesium sulfate and 12.5 g of palladium on activated charcoal (5 percent by weight of Pd) as hydrogenation catalyst were placed in a 1.5 l pressure reactor equipped with a stirrer. At 30° to 35° C., hydrogen was introduced under a pressure of 20 bar for 80 minutes until the pressure remained constant. The reactor contents were thoroughly mixed by stirring during this process. The hydrogenation mixture was cooled to 20° C. and diluted with 200 ml of ethyl acetate and the mixture of hydrous magnesium sulfate and catalyst was filtered off. The solid which had been separated off was washed three times with a total of 200 ml of ethyl acetate and the wash liquor was combined with the filtrate. Diethyl aminomalonate hydrochloride was precipitated out as a white solid by the introduction of 68 g of dry hydrogen chloride, filtered off, washed with ethyl acetate and dried under a water jet vacuum at 70° C. The yield was 359.6 g (85.1% of theory), the melting point was 165° C. and the purity according to the analytically determined chlorine content was 100%.

Diethylaminomalonathydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diethylaminomalonathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 547)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mojin Biotechnology Co., Ltd
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Capot Chemical Co.,Ltd.
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admin@nexconn.com China 7836 58
Accela ChemBio Inc.
(+1)-858-699-3322
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Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58

13433-00-6(Diethylaminomalonathydrochlorid)Verwandte Suche:


  • AMino Malonic diethyl ester hydrochloride
  • Diethyl 2-aminopropanedioate hydrochloride
  • 1,3-diethyl 2-aminopropanedioate, HCl
  • Diethyl aMinoMalonate hydrochloride (AMinoMalonaMid)
  • Diethyl 2-aminomalonate hydrochloride 99%
  • Diethyl aminomalonat
  • Diethyl 2-aminopropane-1,3-dioate hydrochloride
  • Diethyl aMinoMalonate hydrochloride, 98% 25GR
  • 2-Methyl-Malonic acid diethyl ester hydrochloride
  • DIETHYL AMINOMALONATE HYDROCHLORIDE FOR
  • Diethyl aMinoMalonate hydrochloride 98%
  • Diethyl AMinoMalonate Hydrochloride, 95+%
  • Propanedioic acid, 2-amino-, 1,3-diethyl ester, hydrochloride (1:1)
  • Diethyl aminomalote hydrochloride
  • AMINOMALONIC ACID DIETHYL ESTER HCL
  • AMINOMALONIC ACID DIETHYL ESTER HYDROCHLORIDE
  • DIETHYLAMINO MALONATE HCL
  • DIETHYL AMINOMALONATE HYDROCHLORIDE
  • Diethyl 2-Aminomalonate HCl
  • Propanedioic acid, amino-, diethyl ester, hydrochloride
  • aminomalonic acid dlethyl ester hydrochloride
  • Diethyl aminomalonate hydrochloride, 98%+
  • Amoxapine Impurity 6
  • DiethylAminomalonateHydrochloride>
  • Diethyl aminmalonic acid hydrochloride
  • Diethylaminomalonathydrochlorid
  • Favipiravir SW(starting materials)
  • Malonic acid, amino-, diethyl ester, hydrochloride
  • Diethyl 3-aminomalonate hydrochloride
  • Two amino malonic acid ethyl ester hydrochloride
  • AminomaL
  • onate HydrochL
  • aminomalonate hydrochloride
  • Aminomalonamid
  • DIETHYL 2-AMINOMALONATE HYDROCHLORIDE
  • Diethyl 2-aminomalonate
  • diethyl 2-aminopropanedioate
  • TERT-BUTYL4-(2-(2-HYDROXYETHOXY)ETHYL)PIPERAZINE-5-CARBOXYLATE
  • 2-amino-Propanedioic acid 1,3-diethyl ester hydrochloride (1:1)
  • 2-Amino-malonic acid 1,3-diethyl ester HCl
  • Amoxapine Impurity 2 HCl
  • 13433-00-6
  • C7H13NO4xHCl
  • C7H13NO4HCl
  • NH2CH2COOC2H52HCl
  • C7H14ClNO4
  • C7H13NO4ClH
  • AMINE
  • Building Blocks
  • C6 to C7
  • Carbonyl Compounds
  • Organic Building Blocks
  • Esters
  • Building Blocks
  • C6 to C7
  • Carbonyl Compounds
  • Chemical Synthesis
  • Esters
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