3,7-Diaminophenothiazin-5-iumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R42:Sensibilisierung durch Einatmen möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24:Berührung mit der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin and potentiates the procoagulation process by activating factors V, VIII, XI, and XIII. Conversely, thrombin aids the anticoagulant process by activating protein C. Activated protein C inhibits activated factors V and VIII ultimately down-
regulating further thrombin production. Thrombin is often used as a potent platelet activator
in vitro. Platelet responses to thrombin are mediated through protease-
activated receptors (PARs). Thrombin-
mediated signaling regulates a diverse range of metabolic processes including activation of phospholipases in platelets, endothelial cells, and cardiac myocytes.
Chemische Eigenschaften
dark green to black powder or crystals
Verwenden
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess
in vitro hemostatic properties of French lyophilized plasma.
synthetische
The first thiazine dye, named after its dis coverer, was Lauth's Violet, which was obtained in 1876 by joint oxidation of 1,4-phenylenediamine and hydrogen sulfide with iron(III) chloride.
Definition
ChEBI: An organic chloride salt composed of 3,7-diaminophenothiazin-5-ium and chloride ions in a 1:1 ratio. A strongly metachromatic dye, useful for the staining of acid mucopolysaccharides. It is also a common nuclear stain and can be used for the demonstration
f Nissl substance in nerve cells of the CNS.
Allgemeine Beschreibung
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects. Thrombin is also known as coagulation factor IIa. It is a serine endopeptidase that hydrolyzes peptide and ester bonds specifically at the carboxylic side of arginine. This enzyme converts fibrinogen to fibrin.
3,7-Diaminophenothiazin-5-iumchlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
