((3-Chlorphenyl)hydrazono)-malanonitril
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- CAS-Nr.
- 555-60-2
- Bezeichnung:
- ((3-Chlorphenyl)hydrazono)-malanonitril
- Englisch Name:
- CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
- Synonyma:
- CCCP;Carbonyl Cyanide;(3-CHLOROPHENYL)HYDRAZONOMALONONITRILE;MESOXALONITRILE 3-CHLOROPHENYLHYDRAZONE;CCCP;CCCPH;M-CL-CCP;m-Cl-CCP (CCCP);BUTTPARK 91\04-41;TIMTEC-BB SBB003506;CCCP apoptosis inducer;3-chlorophenylhydrazone
- CBNumber:
- CB0421559
- Summenformel:
- C9H5ClN4
- Molgewicht:
- 204.62
- MOL-Datei:
- 555-60-2.mol
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((3-Chlorphenyl)hydrazono)-malanonitril Eigenschaften
- Schmelzpunkt:
- 170-175 °C (dec.)
- Siedepunkt:
- 333.84°C (rough estimate)
- Dichte
- 1.3807 (rough estimate)
- Brechungsindex
- 1.6110 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- methanol: 10 mg/mL, clear, very deep yellow
- Aggregatzustand
- powder
- pka
- 6.00±0.10(Predicted)
- Farbe
- yellow to orange
- Wasserlöslichkeit
- Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
- BRN
- 1842102
- Expositionsgrenzwerte
- NIOSH: IDLH 25 mg/m3
- InChIKey
- UGTJLJZQQFGTJD-UHFFFAOYSA-N
- CAS Datenbank
- 555-60-2(CAS DataBase Reference)
- EPA chemische Informationen
- Propanedinitrile, [(3-chlorophenyl)hydrazono]- (555-60-2)
((3-Chlorphenyl)hydrazono)-malanonitril Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
CCCP is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. It inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively. CCCP inhibits activation of stimulation of interferon genes (STING), decreasing the expression of downstream STING targets, including IFN-β, TBK1, and IRF3 when used at a concentration of 50 μM in RAW 264.7 cells. It induces mitochondrial fission in a manner dependent on the GTPase Drp1. CCCP (4 mg/kg) increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats. It also increases myocardial glucose and fatty acid uptake in rats.
Chemische Eigenschaften
yellow to orange-brown crystalline powder
Verwenden
Carbonyl cyanide 3-chlorophenylhydrazone is a widely used uncoupler of oxidative phosphorylation.
Biologische Aktivität
Widely used uncoupler of oxidative phosphorylation.
((3-Chlorphenyl)hydrazono)-malanonitril Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
((3-Chlorphenyl)hydrazono)-malanonitril Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 135)Lieferanten
555-60-2(((3-Chlorphenyl)hydrazono)-malanonitril)Verwandte Suche:
- [(3-chlorophenyl)hydrazono]-propanedinitril
- m-chlorophenylcarbonylcyanidehydrazone
- mesoxalonitrile,(m-chlorophenyl)hydrazone
- M-CL-CCP
- MESOXALONITRILE (3-CHLOROPHENYL)HYDRAZONE
- BUTTPARK 91\04-41
- CARBONYL CYANIDE M-CHLOROPHENYL-HYDRAZONE
- CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
- [(3-CHLOROPHENYL)HYDRAZONO]PROPANEDINITRILE
- [(3-chlorophenyl)hydrazono]malononitrile
- CARBONYL CYANIDE M-CHLOROPHENYL &
- Carbonylcyanide3-chlorophenylhydrazone,98%
- Carbonyl cyanide 3-chlorophenylhydrazone, 99+%
- Carbonylcyanid-m-chlorphenylhydrazon
- m-Cl-CCP, Carbonyl cyanide 3-chlorophenylhydrazone, CCCP, Mesoxalonitrile (3-chlorophenyl)hydrazone, Mesoxalonitrile 3-chlorophenylhydrazone
- m-Cl-CCP, CCCP, Mesoxalonitrile 3-chlorophenylhydrazone
- Carbonyl cyanide m-chlorophenylhydrazone, 99+%
- 2-[(3-Chlorophenyl)hydrazono]propanedinitrile
- CCCPH
- Carbonyl cyanide 3-chlorophenylhydrazone,m-Cl-CCP, CCCP, Mesoxalonitrile 3-chlorophenylhydrazone
- (3-chlorophenyl)carbonohydrazonoyl dicyanide
- TIMTEC-BB SBB003506
- ((3-chlorophenyl)hydrazono)-propanedinitril
- 3-chlorophenylhydrazone
- Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem
- Propanedinitrile, 2-[2-(3-chlorophenyl)hydrazinylidene]-
- 2-[2-(3-Chlorophenyl)hydrazinylidene]propanedinitrile
- CCCP apoptosis inducer
- m-Cl-CCP (CCCP)
- 2-[(3-chlorophenyl)hydrazinylidene]propanedinitrile
- N-(3-chlorophenyl)carbonohydrazonoyldicyanide
- Carbonyl Cyanide
- CCCP
- (3-CHLOROPHENYL)HYDRAZONOMALONONITRILE;MESOXALONITRILE 3-CHLOROPHENYLHYDRAZONE;CCCP
- CCCP，Mesoxalonitrile 3-chlorophenylhydrazone
- 555-60-2
- C9H5ClN4
- C9H5CIN4
- ClC6H4NHNCCN2
- Organic Covalent Modifiers
- Enzyme Inhibitors
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors by Type
- BioChemical
- Biochemicals and Reagents
- Caspases/Apoptosis
