(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
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- CAS-Nr.
- 877397-65-4
- Englisch Name:
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- Synonyma:
- (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethano;(S)-1-(2,6-DichL;JACS-877397-65-4;Crizotinib Interm 7654;-1-(2,6-Dichloro-3-fluorophenyl);(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-dichloro-4-fluorophenyl)ethanol;(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol;(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
- CBNumber:
- CB11503932
- Summenformel:
- C8H7Cl2FO
- Molgewicht:
- 209.04
- MOL-Datei:
- 877397-65-4.mol
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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Eigenschaften
- Siedepunkt:
- 261.3±35.0 °C(Predicted)
- Dichte
- 1.406±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.30±0.20(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White
- InChI
- InChI=1/C8H7Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-4,12H,1H3/t4-/s3
- InChIKey
- JAOYKRSASYNDGH-UFLUHPNLNA-N
- SMILES
- [C@H](C1C(=CC=C(F)C=1Cl)Cl)(O)C |&1:0,r|
- CAS Datenbank
- 877397-65-4
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| HazardClass |
IRRITANT |
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| HS Code |
2906290090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P405 |
Unter Verschluss aufbewahren. |
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(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (
c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
Synthese
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is synthesised using (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate as a raw material by chemical reaction. The specific synthesis steps are as follows:
Sodium methoxide (19 mmol; 0.5 M in methanol) was added slowly to compound S-2 (4.64 g, 18.8 mmol) under a nitrogen atmosphere at 0° C. The resulting mixture was stirred at room temperature for 4 hours. The solvent was evaporated and H2O (100 mL) was added. The cooled reaction mixture was neutralized with sodium acetate-acetic acid buffer solution to pH 7. Ethyl acetate (100 mL.x.2) was added to extract the aqueous solution. The combined organic layers were dried over Na2SO4, filtered, and evaporated to obtain S-1 as a white solid (4.36 g, 94.9percent yield); SFC-MS: 97percent ee. 1H NMR (400 MHz, chloroform-D) δ ppm 1.65 (d, J=6.8 Hz, 3 H) 5.58 (q, J=6.9 Hz, 1H) 6.96-7.10 (m, 1H) 7.22-7.36 (m, 1H).
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 292)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
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Shanghai Yingrui Biopharma Co.,Ltd
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21-33585366
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export01@shyrchem.com |
CHINA |
1320 |
58 |
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SyncoZymes (Shanghai) Co., Ltd.,
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+86-021-68187180-811 +86-13681683526
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lchen@syncozymes.com |
China |
188 |
58 |
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Hebei Mojin Biotechnology Co., Ltd
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+8613288715578
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sales@hbmojin.com |
China |
12456 |
58 |
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Henan Bao Enluo International TradeCo.，LTD
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+86-17331933971 +86-17331933971
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deasea125996@gmail.com |
China |
2503 |
58 |
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Henan Fengda Chemical Co., Ltd
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+86-371-86557731 +86-13613820652
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info@fdachem.com |
China |
7845 |
58 |
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Frapp's ChemicalNFTZ Co., Ltd.
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+86 (576) 8169-6106
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sales@frappschem.com |
China |
885 |
50 |
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Capot Chemical Co.,Ltd.
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571-85586718 +8613336195806
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sales@capotchem.com |
China |
29797 |
60 |
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Shanghai Daken Advanced Materials Co.,Ltd
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+86-371-66670886
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info@dakenam.com |
China |
15928 |
58 |
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Beijing Cooperate Pharmaceutical Co.,Ltd
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010-60279497
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sales01@cooperate-pharm.com |
CHINA |
1811 |
55 |
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Hangzhou FandaChem Co.,Ltd.
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008657128800458; +8615858145714
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fandachem@gmail.com |
China |
9348 |
55 |
877397-65-4()Verwandte Suche:
- BenzeneMethanol,2,6-dichloro-3-fluoro-a-Methyl-, (aS)-
- (1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
- (S)-1-(2,6-dichloro-4-fluorophenyl)ethanol
- (1S)-1-(2,6-Dichloro-3-fluorophenyl)ethane-1-ol
- (aS)-2,6-Dichloro-3-fluoro-a-methyl-benzenemethanol
- -1-(2,6-Dichloro-3-fluorophenyl)
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
- JACS-877397-65-4
- (S)-1-(2,6-DichL
- Benzenemethanol, 2,6-dichloro-3-fluoro-α-methyl-, (αS)-
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol ISO 9001：2015 REACH
- Crizotinib Interm 7654
- (S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol
- (S)-1-(2,6-Dichloro-3-fluorophenyl)ethano
- (αS)-2,6-Dichloro-3-fluoro-α-methylbenzenemethanol
- (S)-l-(2,6-Dichl〇T〇-3 -fluorophenyl)ethanolethanol
- 877397-65-4
- 877399-65-4
- Aromatic Ring
- Chiral Compounds
