Latanoprost
|
|
|
- CAS-Nr.
- 130209-82-4
- Englisch Name:
- Latanoprost
- Synonyma:
- 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate;xa41;Xalata;phxa41;Latanopros;LATANOPROST;LATANAPROST;Latanoprost>Latanoprost
CAS
- CBNumber:
- CB1208384
- Summenformel:
- C26H40O5
- Molgewicht:
- 432.59
- MOL-Datei:
- 130209-82-4.mol
|
Latanoprost Eigenschaften
- alpha
- D20 +31.57° (c = 0.91 in acetonitrile)
- Siedepunkt:
- 583.8±50.0 °C(Predicted)
- Dichte
- 1.093±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: freely soluble
- Aggregatzustand
- oil
- pka
- 14.84±0.70(Predicted)
- Farbe
- pale yellow
- Merck
- 14,5376
- BCS Class
- 2
- InChIKey
- GGXICVAJURFBLW-RDSJPUOVSA-N
- CAS Datenbank
- 130209-82-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
MJ9669550 |
|
|
| HS Code |
2937500000 |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
|
|
|
|
| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
|
Latanoprost Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Xalatan was launched in Sweden, Switzerland and the US for the treatment
of glaucoma. It can be synthesized, from the Corey lactone, using standard
prostaglandin chemistry. Latanoprost is a PGF
2α, analog that is more lipophilic thus
is better able to penetrate the cornea. The (15R)-diastereomer has only 10% of the
activity compared to the (15S)-diastereomer. It is a selective FP receptor agonist
with little or no effect on the other prostanoid receptors. The antiglaucoma effects
are the result of reduced intraocular pressure arising by increasing uveoscleral
outflow with little or no effect on trabeculo-canalicular aqueous outflow and no effect
on retinal vasculation or permeability of the blood-aqueous barrier. The topical
application is sufficient for a single daily dosage and is well tolerated with no
detectible conjunctival hyperaemia.
Chemische Eigenschaften
Light Yellow Thick Oil
Verwenden
Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.
Definition
ChEBI: A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.
Allgemeine Beschreibung
Latanoprost (Xalatan) is available as a 0.005% sterileophthalmic solution in a 2.5-mL dispenser bottle.Latanoprost is also marketed as a combination ophthalmicproduct with the β-adrenergic blocking agent, timolol,which apparently enhances IOP-lowering by decreasing theproduction of aqueous humor. Cautions and side effects aresimilar to those for other ophthalmic prostanoids.
Sicherheitsprofil
A poison by ingestion
and intravenous route. Human systemic
effects. When heated to decomposition it
emits acrid smoke and irritating vapors.
Latanoprost Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Latanoprost Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 553)Lieferanten
130209-82-4()Verwandte Suche:
- ISOPROPYL (5Z, 9A,11A,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OATE
- LATANOPROST
- [1R-[1α(Z)，2β(R^<*>^)，3α，5α]]-7-[3，5-Dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)cyclopentyl]-5-heptenoic acid 1-methylethyl ester
- Xalata
- Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoat
- Latanopros
- Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate
- Latanoprost ,98%
- 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-
- cGMP Latanoprost
- propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
- Latanoprost (50 mg)
- Latanoprost, >=99%
- Latanoprost API
- (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptanoic acid 1-methylethyl ester
- Isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-en
- 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate
- Propan-2-yl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate
- LATANOPROST WS & IMPURITY
- 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID, ISOPROPYL ESTER
- 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROS-5Z-EN-1-OIC ACID, ISOPROPYL ESTER
- (1r-(1-alpha(z),2-beta(r*),3-alpha,5-alpha))--methylethyleste
- 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoicaci1
- phxa41
- xa41
- isopropyl (5z,9α,11α,15r)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate
- LATANAPROST
- 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 1-methylethyl ester, (5Z)- (9CI)
- 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl]-, 1-methylethyl ester, [1R-[1a(Z),2b(R*),3a,5a]]-
- Lata prostaglandin
- (Z)-isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate
- ratanprostaglandin
- Latanoprost>
- 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
- Latanoprost USP/EP/BP
- Prostaglin Latanoprost
- Latanoprost (PHXA41, XA34)
- LatanoprostQ: What is
Latanoprost Q: What is the CAS Number of
Latanoprost Q: What is the storage condition of
Latanoprost Q: What are the applications of
Latanoprost
- Latanoprost (1357475)
- 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
- Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
- propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
- Isopropyl (Z)-7-((1S,2S,3S,5R)-3,5-Dihydroxy-2-((S)-3- hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate
- Latanoprost
CAS
- 130209-82-4
- 30209-82-4
- 13029-82-4
- Prostaglandin
- Prostaglandins
- Active Pharmaceutical Ingredients
- Other APIs
- Aromatics
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
- Key Products
- 130209-82-4
