5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Pale Yellow Crystalline Solid
benefits
Apigenin has various beneficial health effects such as antioxidant, anti-inflammatory, and chemoprevention. Apigenin can downregulate the expression of IL-1β and TNF-α in LPS-stimulated mouse macrophages and human monocytes.
preclinical studies have suggested that apigenin may improve outcomes in multiple health states, including anxiety, brain function, oxidative stress, inflammation, and hormonal regulation (testosterone, estrogen, and cortisol
Anticancer Research
It induces apoptosis by targeting leptin/leptin receptor pathway and by targeting caspase-dependent extrinsic pathway aswell as STAT3 signaling pathway in lung adenocarcinoma and BT-474 breast cancercells, respectively.
It shows antitumor activity against breastcancer MCF-7 cells and colon cancer HCT 116 cells and is a mediator of cancerchemoprevention and an inducer of autophagy. It can be used to treat colon canceras it induces apoptosis in colon cancer cells. It also increase melanogenesis in B16cells by activating the p38 MAPK pathway.
läuterung methode
The current method for the purification of apigenin is crude-solvent extraction method by using solvent in small quantity and also time saving. Apigenin that was isolated from Symphyotrichum novae-angliae was obtained in large quantity and directly from extract.
Einzelnachweise
[1] Bahare Salehi, et al. “The Therapeutic Potential of Apigenin.” Int J Mol Sci. 2019 Mar; 20(6): 1305.
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
