Chitosan

Chitosan Struktur
9012-76-4
CAS-Nr.
9012-76-4
Englisch Name:
Chitosan
Synonyma:
Chitosan oligosaccharides;Flocculant;Chitosane;poliglusam;CARBOXYLATION;Oligochitosan;seacureplus;DEACETYLATED CHITIN;Amino-oligosaccharin;CHITOSANNANOPARTICLES
CBNumber:
CB1479274
Summenformel:
C6H11NO4X2
Molgewicht:
161.16
MOL-Datei:
9012-76-4.mol

Chitosan Eigenschaften

Schmelzpunkt:
102.5 °C
Dichte
1 g/cm3
storage temp. 
2-8°C
Löslichkeit
dilute aqueous acid (pH <6.5).: soluble
Aggregatzustand
(Coarse ground flakes and powder)
Farbe
White to Off-white
Geruch (Odor)
Odorless
Stabilität:
Stable. Incompatible with strong oxidizing agents.
LogP
-11.706 (est)
CAS Datenbank
9012-76-4
EPA chemische Informationen
Chitosan (9012-76-4)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 20/21/22-36/37/38
S-Sätze: 24/25-36-26
WGK Germany  -
RTECS-Nr. FM6300000
3
TSCA  Yes
HS Code  39139000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Chitosan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’.

Occurrence

Chitosan comes from the shell of marine crustaceans.

Verwenden

Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.Flocculant, protein precipitation, encapsulating agent and aqueous thickener.
Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application.
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

Vorbereitung Methode

Chitosan is manufactured commercially by chemically treating the shells of crustaceans such as shrimps and crabs. The basic manufacturing process involves the removal of proteins by treatment with alkali and of minerals such as calcium carbonate and calcium phosphate by treatment with acid. Before these treatments, the shells are ground to make them more accessible. The shells are initially deproteinized by treatment with an aqueous sodium hydroxide 3–5% solution. The resulting product is neutralized and calcium is removed by treatment with an aqueous hydrochloric acid 3–5% solution at room temperature to precipitate chitin. The chitin is dried so that it can be stored as a stable intermediate for deacetylation to chitosan at a later stage. NDeacetylation of chitin is achieved by treatment with an aqueous sodium hydroxide 40–45% solution at elevated temperature (1108℃), and the precipitate is washed with water. The crude sample is dissolved in acetic acid 2% and the insoluble material is removed. The resulting clear supernatant solution is neutralized with aqueous sodium hydroxide solution to give a purified white precipitate of chitosan. The product can then be further purified and ground to a fine uniform powder or granules. The animals from which chitosan is derived must fulfil the requirements for the health of animals suitable for human consumption to the satisfaction of the competent authority. The method of production must consider inactivation or removal of any contamination by viruses or other infectious agents.

benefits

Chitosan is a fibrous substance that might reduce how much fat and cholesterol the body absorbs from foods. It also helps blood clot when applied to wounds.

Allgemeine Beschreibung

Chitosan is a linear amino polysaccharide composed of approximately 20% β1,4-linked N-acetyl-D-glucosamine (GlcNAc) and approximately 80% β1,4-linked D-glucosamine (GlcN) that is prepared by the partial deacetylation of chitin in hot alkali.

Pharmazeutische Anwendungen

Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies. These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery. Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes.

Sicherheit(Safety)

Chitosan is being investigated widely for use as an excipient in oral and other pharmaceutical formulations. It is also used in cosmetics. Chitosan is generally regarded as a nontoxic and nonirritant material. It is biocompatible with both healthy and infected skin. Chitosan has been shown to be biodegradable.
LD50 (mouse, oral): >16 g/kg

Lager

Chitosan powder is a stable material at room temperature, although it is hygroscopic after drying. Chitosan should be stored in a tightly closed container in a cool, dry place. The PhEur 6.5 specifies that chitosan should be stored at a temperature of 2–88℃.

Inkompatibilitäten

Chitosan is incompatible with strong oxidizing agents.

Regulatory Status

Chitosan is registered as a food supplement in some countries.

Chitosan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chitosan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 816)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
Xi'an ZB Biotech Co.,Ltd
+8618591943808
sales01@xazbbio.com China 819 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9427 58
Hubei Aumei New Material Co., Ltd.
+86-027-87366298 +8615927270571
tianyi@skbiology.cn China 294 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763
sales@tnjchem.com China 25363 58
Maanshan Tiantai Biotechnology Co., Ltd.
+86-0555-8889890 +86-17356584060
GM@tiantaibio-tech.com China 72 58
Junwee Chemical co., Ltd.
+86-571-85808636 +86-13958122542
sales@junweechem.com China 771 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 42 58
Anhui Yiao New Material Technology Co., Ltd
+86-199-55145978 +8619955145978
sales8@anhuiyiao.com China 253 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2504 58

9012-76-4()Verwandte Suche:


  • kimitsuchitosanm
  • kytexh
  • Chitosan, molecular weight: 100,000-300,000
  • (Poly-N-acetyl--D-glucosamine)-protein
  • 2-amino-2-deoxy-(1→4)-β-d-glucopyranan
  • CHITOSAN,POWDER
  • CHITOSAN,POWDER(BULK
  • methyl N-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6S)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate
  • CHITOSAN(RG)
  • BC 10 (polysaccharide)
  • CTA 1 Lactic Acid
  • Daichitosan VL
  • N-Deacetylchitin
  • Sea Cure 440
  • WOT Recovery Floc T
  • Chitosan, MW. 100,000-300,000
  • Chitosan,molecular weight: 600,000-800,000
  • Chitosan (5-20mPa.s, 0.5% in 0.5% Acetic Acid at 20deg C)
  • Chitosan (50-100mPa.s, 0.5% in 0.5% Acetic Acid at 20deg C)
  • Chitosan (200-500mPa.s, 0.5% in 0.5% Acetic Acid at 20deg C)
  • Poly-(1,4-β-D-glucopyranosamine)
  • Poly-(1→4)-β-D-glucosamine
  • Poly[beta-(1,4)-2-amino-2-deoxy-D-glucose], Poly[beta-(1,4)-D-glucosamine]
  • Chitosan (500 mg)
  • Chitosan, Molecular weight: 100,000-300,000 100GR
  • Chitosan, Molecular weight: 100,000-300,000 50GR
  • Chitosan (Coarse ground flakes and powder)
  • Chitosan froM shriMp shells, practical grade
  • Chitosan high purity, Mv 110,000-150,000
  • Chitosan high purity, Mv 60,000-120,000
  • Chitosan,Deacetylated chitin, Poly(D-glucosamine)
  • Chitosan from shrimp shells
  • kytexm
  • seacuref
  • LOWMOLECULARWEIGHTCHITOSAN
  • HIGHMOLECULARWEIGHTCHITOSAN
  • POLY-DELTA-GLUCOSAMINE
  • CHINESETHOROWAXROOTP.E.
  • CHITOSAN, QUICK DISSOLVE
  • CHITOSAN (DEACETYLATED CHITIN)
  • Poly-d-hlocozoamine, yactnyno N-acetylirobann (TY 6-01-1-458-93
  • CHITOSAN - 100 MESH - BULK DENSITY >0.25
  • CHITOSAN - 100 MESH - BULK DENSITY >0.5
  • CHITOSAN - 140 MESH - BULK DENSITY >0.25
  • CHITOSAN - 140 MESH - BULK DENSITY >0.5
  • CHITOSAN - 40 MESH - BULK DENSITY >0.25
  • CHITOSAN - 40 MESH - BULK DENSITY >0.5
  • CHITOSAN ( FLONAC C )
  • CHITOSAN ( FLONAC H )
  • CHITOSAN ( FLONAC N )
  • CHITOSAN ( FS1)
  • CHITOSAN FC-80
  • CHITOSAN FCHD-80
  • CHITOSAN FCMD-100
  • CHITOSAN FOOD GRADE 100 MESH DAC>90% BULK DENSITY
  • CHITOSAN FOOD GRADE 140 MESH DAC>90% BULK DENSITY
  • CHITOSAN FOOD GRADE 40 MESH DAC>90% BULK DENSITY >
  • Chitosan from crab shells, Deacetylated chitin, Poly(D-glucosamine)
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