Tributylcitrat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Tributyl citrate is a clear, odorless, practically colorless, oily liquid.
Verwenden
Tributyl Citrate, is a non-phthalate plasticizer, that can be used for the preparation of resins. It can also used for the synthesis of Acetyl Tributyl Cirate, a valuable biodegradable plasticizer of low toxicity, found in nail polish and other cosmetics.
Vorbereitung Methode
Tributyl citrate is prepared by the esterification of citric acid with
butanol.
Allgemeine Beschreibung
Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Pharmazeutische Anwendungen
Tributyl citrate is used to plasticize polymers in formulated
pharmaceutical coatings. The coating applications include capsules,
tablets, beads, and granules for taste masking, immediate release,
sustained-release, and enteric formulations.
Sicherheit(Safety)
Tributyl citrate is used in oral pharmaceutical formulations. It is
generally regarded as an essentially nontoxic and nonirritating
material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): 2.9 g/kg
LD50 (rat, oral): >30 mL/kg
Lager
Tributyl citrate should be stored in well-closed containers in a cool,
dry location at temperatures not exceeding 38℃. When stored in
accordance with these conditions, tributyl citrate is a stable
material.
Inkompatibilitäten
Tributyl citrate is incompatible with strong alkalis and oxidizing
materials.
Regulatory Status
Approved in the USA for indirect food contact in food films.
Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
Tributylcitrat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
