9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol

Vitamin D2 Struktur
50-14-6
CAS-Nr.
50-14-6
Bezeichnung:
9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
Englisch Name:
Vitamin D2
Synonyma:
ERGOCALCIFEROL;VITAMIN D;CALCIFEROL;Calderol;VitaMin D2-d3;Drisdol;Doral;Crtron;Deltalin;Sterogyl
CBNumber:
CB3731934
Summenformel:
C28H44O
Molgewicht:
396.65
MOL-Datei:
50-14-6.mol

9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Eigenschaften

Schmelzpunkt:
114-118 °C(lit.)
alpha 
82 º (c=3, in acetone 25 ºC)
Siedepunkt:
460.3°C (rough estimate)
Dichte
0.9784 (rough estimate)
Dampfdruck
7 x l0-7 Pa (20 °C), est.)
Brechungsindex
1.5100 (estimate)
Flammpunkt:
14 °C
storage temp. 
-20°C
Löslichkeit
H2O: 200 mg/mL, clear to hazy
Aggregatzustand
powder
pka
14.74±0.20(Predicted)
Farbe
white to yellowish
Optische Aktivität
[α]20/D +105±2°, c = 4% in ethanol
Wasserlöslichkeit
Soluble in ethanol, water, methanol, dimethylformamide, and dimethyl sulfoxide.
Merck 
14,10018
BRN 
1916682
BCS Class
3
Stabilität:
Light Sensitive
InChIKey
MECHNRXZTMCUDQ-RKHKHRCZSA-N
LogP
10.440 (est)
CAS Datenbank
50-14-6(CAS DataBase Reference)
NIST chemische Informationen
Ergocalciferol(50-14-6)
EPA chemische Informationen
Ergocalciferol (50-14-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,T+,T,F
R-Sätze: 22-48/25-26-24/25-40-23/24/25-48/22-23-11-20
S-Sätze: 28-36/37-45-28A-36-26-36/37/39-22-16-7
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS-Nr. KE1050000
1-8-10
TSCA  Yes
HazardClass  6.1(a)
PackingGroup  II
HS Code  29362900
Giftige Stoffe Daten 50-14-6(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H330 Lebensgefahr bei Einatmen. Akute Toxizität inhalativ Kategorie 1 Achtung P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H372 Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 1 Achtung P260, P264, P270, P314, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P314 Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen.

9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R48/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Verschlucken.
R26:Sehr giftig beim Einatmen.
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Beschreibung

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity. Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet light. Vitamin D2 is produced in fungi, including yeast, and invertebrates from ergosterol in response to ultraviolet radiation. In vertebrates as well as host organisms, vitamin D2 is metabolized first to 25-hydroxyvitamin D2 and subsequently to the active 1,25-dihydroxyvitamin D2. Differences in the metabolism and action of vitamin D2 vs. vitamin D3 in mammals is a current topic of research interest.

Chemische Eigenschaften

Ergocalciferol is an odorless white crystalline solid

Verwenden

Vitamin d2 is fat-soluble, and is stable unless oxidized. It is necessary for growth and maintenance of teeth and bones and the normal utilization of calcium and phosphorus; it is used medicinally in the treatment of rickets and as a dietary supplement. Its sources include fish liver and vitamin d-fortified milk.

Definition

ChEBI: A vitamin D supplement and has been isolated from alfalfa.

Allgemeine Beschreibung

Odorless white crystals. Used as a dietary supplement and food additive.

Reaktivität anzeigen

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

Vitamin D2 poisoning disturbs calcium metabolism and causes kidney damage. Vitamin D2 in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D. Those with hypercalcemia are at a greater risk.

Brandgefahr

Shows signs of decomposition when stored for a few days at room temperature.

Sicherheitsprofil

Poison by ingestion, intraperitoneal, intravenous, and intramuscular routes. An experimental teratogen. Human systemic effects by ingestion: anorexia, nausea or vomiting, and weight loss. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

mögliche Exposition

Used as a nutrient and/or dietary supplement food additive

Stoffwechselwegen

Ergocalciferol (vitamin D2) is a product made by the UV irradiation of yeast ergosterol. It is a common form of vitamin D and it has very similar biological activity to that of cholecalciferol (vitamin D3) in the treatment of the vitamin D deficiency diseases (e.g. rickets). The bioactive form of this vitamin is also the 1,25-dihydroxy-derivative and this has equal antirachitic activity to that of the cholecalciferol analogue (Jones et al., 1975).

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

läuterung methode

It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 IV 4404.]

Inkompatibilitäten

Dust may be combustible and may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

Waste disposal

Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffeegrounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 685)Lieferanten
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Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 990 58
Capot Chemical Co.,Ltd.
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sales@capotchem.com China 29797 60
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17791478691
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50-14-6(9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol)Verwandte Suche:


  • Arthin
  • VD2,Ergocal ciferol
  • ERGOCALCIFEROL (D2) 100MG NEAT
  • ERGOCALCIFEROL, PH EUR
  • ERGOCALCIFEROL CELL CULTURE TESTED
  • VITAMIN D2-WATER SOLUBLE
  • VITAMIN D2 USP CRYSTALLINE
  • VITAMIN D2 USP, 850000 I.U. G
  • 5,7,10(19),22-CHOLESTATETRAEN-24BETA-METHYL-3BETA-OL-9,10-SECO
  • 5,7,10(19),22-CHOLESTATETRAEN-24B-METHYL-3B-OL-9,10-SECO
  • Ergocalciferol (D2)
  • Ergocalciferol/VitaminD2
  • Ergocalciferol(VitaminD2PowderWaterSoluble)1,500,000Iu
  • VitaminD2Oil5,000,000Iu
  • ERGOCALCIFEROLOIL(400,000IU)
  • 3-[2-[1-(5,6-dimethylhept-3-en-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol
  • VITAMIN D2(ERGOCALCIFEROL)(RG)
  • VITAMIN D2(ERGOCALCIFEROL)(SH)
  • 5 ampules) (Vitamin D2)
  • Ergocalciferol (30 mg/ampule
  • VitaMin D2, 99% 1GR
  • VitaMin D2, 99% 5GR
  • (5Z,7E,22E)-9,10-seco-ergosta-5,7,10(19),22-tetraen-3β-ol
  • VitaMin D2-d6 or Ergocalciferol D6
  • VITAMIN D2(ERGOCALCIFEROL)(P)
  • VitaMin D2, 40000 IU/Mg
  • VitaMin D2 0
  • Cyclohexanol, 4-methylene-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-, (1S,3Z)-
  • Vitamin D2 solution
  • Ergocalciferol (6,19,19-d3)
  • Ergocalciferol d6
  • Calciferol solution
  • 10-Secoergosta-5,7,10,22-tetraen-3-ol
  • Vitamin D2 〔Calciferol〕
  • ERGOCALCIFEROL >= 98.0% (HPLC, SUM O
  • Irradiated rgosterol
  • 9,10-secoergosta-5,7,10(19),22-tetra-en-3-ol
  • 9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol, (3beta,5Z,7E,22E)-
  • activatedergosterol
  • Buco-D
  • Calciferol (vitamin D2)
  • Calciferon 2
  • calciferon2
  • component of Geltabs Vitamin D
  • component of Haliver
  • Condacaps
  • Condol
  • Daral
  • D-Arthin
  • Davitamon D
  • davitamond
  • Davitin
  • Decaps
  • Dee-Osterol
  • Dee-Ron
  • Dee-Ronal
  • Dee-Roual
  • minad2
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