LACOSAMIDE
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- CAS-Nr.
- 175481-36-4
- Englisch Name:
- LACOSAMIDE
- Synonyma:
- ViMpat;Erlosamide;Lacosamide API;(R)-2-Acetamido-N-benzyl-3-methoxypropanamide;(2R)-2-acetamido-N-benzyl-3-methoxy-propanamide;SPM 927;LACOSAMIDE;ADD 243037;Lacoxamide;Lacosamine
- CBNumber:
- CB41011740
- Summenformel:
- C13H18N2O3
- Molgewicht:
- 250.29
- MOL-Datei:
- 175481-36-4.mol
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LACOSAMIDE Eigenschaften
- Schmelzpunkt:
- 141-143?C
- alpha
- D23 +16.0° (c = 1 in CH3OH)
- Siedepunkt:
- 536.4±50.0 °C(Predicted)
- Dichte
- 1.120±0.06 g/cm3(Predicted)
- Flammpunkt:
- 2℃
- storage temp.
- Refrigerator
- Löslichkeit
- DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2 mg/ml
- Aggregatzustand
- A crystalline solid
- pka
- 14.19±0.46(Predicted)
- InChIKey
- VPPJLAIAVCUEMN-GFCCVEGCSA-N
- CAS Datenbank
- 175481-36-4
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P210 |
Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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LACOSAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Although epilepsy is a neurological disorder with varying etiology and
severity, the common feature is unprovoked, recurring seizures. Whether
classified as generalized, involving both cerebral hemispheres, or partial
with only localized portions of brain participation at onset, effective
treatment relies on accurate assessment of syndrome type to optimally
decrease the frequency, duration, and severity of seizures. The
latest weapon against partial onset epilepsy is lacosamide, formerly
known as harkoseride and erlosamide. The data also indicate that lacosamide
binds to collapsing response mediator protein 2 (CRMP2); CRMP2 is
involved in neuronal differentiation, control of axonal outgrowth, and
possibly epileptogenesis. Furthermore, lacosamide is heralded as having
a dual mode of action as it has also displayed efficacy against diabetic
neuropathy, possibly as a result of stabilization of neuronal hyperexcitability. Currently,lacosamide is approved as adjunctive treatment of partial onset seizures in patients 17 years or older and is in development as a monotherapy
for epilepsy and for neuropathic pain.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
A potent anticonvulsant.
LACOSAMIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
LACOSAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 480)Lieferanten
175481-36-4()Verwandte Suche:
- LACOSAMIDE
- (2R)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide
- ADD 243037
- Harkoseride
- SPM 927
- (2R)-N-benzyl-2-acetaMido-3-MethoxypropanaMide
- LacosaMide (1.0Mg/ML in Acetonitrile)
- (R)-2-Acetamido-N-benzyl-3-methoxypropionamide
- Lacosamide solution
- Lacosamide-d3 (Acetyl-d3)
- (2R)-2-ACETAMIDO-3-METHOXY-N-(PHENYLMETHYL)PROPANAMIDE
- (R)-2-acetamido-N-benzyl-3-_x001f_methoxypropionamide
- Lacosamide CRS
- Propanamide, 2-(acetylamino)-3-methoxy-N-(phenylmethyl)-, (2R)-
- Can sand meters
- LACOSAMIDE USP/EP/BP
- 2R-(acetylamino)-3-methoxy-N-(phenylmethyl)-propanamide
- LACOSAMIDE (Y0001982)
- LacosamideQ: What is
Lacosamide Q: What is the CAS Number of
Lacosamide Q: What is the storage condition of
Lacosamide Q: What are the applications of
Lacosamide
- Lacosamide for system suitability (Y0001973)
- Lacosamide for system suitability CRS (Y0001973)
- (2R)-2-acetamido-N-benzyl-3-methoxy-propanamide
- Erlosamide
- (R)-2-Acetamido-N-benzyl-3-methoxypropanamide
- ViMpat
- Lacosamide API
- Propanoicacid,7-methyl-,tetradecylester
- Lacoxamide
- Lacosamide solution iMpurity
- Lacosamide
(2R)-2-(Acetylamino)-3-methoxy-N-
(phenylmethyl)propanamide
- Lacosamine
- Lecosamide Reference Standard
- 175481-36-4
- Inhibitors
- Other APIs
- API
- Pharmaceutical raw material
- Amino Acids 13C, 2H, 15N
- Amino Acids & Derivatives
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 175481-36-4
