Lidocainhydrochlorid

Lidocaine hydrochloride Struktur
73-78-9
CAS-Nr.
73-78-9
Bezeichnung:
Lidocainhydrochlorid
Englisch Name:
Lidocaine hydrochloride
Synonyma:
LIDOCAINE HCL;LIGNOCAINE HYDROCHLORIDE;Lidocaine HCI;rucainahydrochloride;duncainehydrochloride;gravocainhydrochloride;leostesinhydrochloride;xylocitinhydrochloride;2-diethylamino-2’,6’-acetoxylididehydrochloride;alpha-diethylamino-2,6-acetoxylidinehydrochloride
CBNumber:
CB4117973
Summenformel:
C14H23ClN2O
Molgewicht:
270.8
MOL-Datei:
73-78-9.mol

Lidocainhydrochlorid Eigenschaften

Schmelzpunkt:
80-82°C
storage temp. 
Inert atmosphere,2-8°C
Wasserlöslichkeit
Water : ≥ 36 mg/mL (132.94 mM)
InChI
InChI=1S/C14H22N2O.ClH/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H
InChIKey
IYBQHJMYDGVZRY-UHFFFAOYSA-N
SMILES
C(NC1=C(C)C=CC=C1C)(=O)CN(CC)CC.[H]Cl
LogP
2.359 (est)
CAS Datenbank
73-78-9(CAS DataBase Reference)
EPA chemische Informationen
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride (73-78-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  3249
HazardClass  6.1(b)
PackingGroup  III
Toxizität LD50 oral in mouse: 220mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Lidocainhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

Definition

ChEBI: Lidocaine hydrochloride is the anhydrous form of the hydrochloride salt of lidocaine. It functions as both a local anesthetic and cardiac depressant, and is commonly used as an antiarrhythmic agent. Its potency is higher and its effects last longer than those of procaine, but its duration of action is shorter than that of bupivacaine or prilocaine.

Biologische Funktion

Lidocaine hydrochloride (Xylocaine) is the most commonly used local anesthetic. It is well tolerated, and in addition to its use in infiltration and regional nerve blocks, it is commonly used for spinal and topical anesthesia and as an antiarrhythmic agent. Lidocaine has a more rapidly occurring, more intense, and more prolonged duration of action than does procaine.

Allgemeine Beschreibung

Lidocaine hydrochloride,2-(diethylamino)-2 ,6 -acetoxylidide monohydrochloride(Xylocaine), was conceived as a derivative of gramine(3-dimethylaminomethylindole) and introduced as a localanesthetic. It is now being used intravenously as a standardparenteral agent for suppression of arrhythmias associatedwith acute myocardial infarction and cardiac surgery.It isthe drug of choice for the parenteral treatment of prematureventricular contractions.

Clinical Use

Lidocaine hydrochloride is a class IB antiarrhythmicagent with a different effect on the electrophysiologicalproperties of myocardial cells from that of procainamideand quinidine. It binds with equal affinity to the active (A)and inactive (I) Na+ ion channels. It depresses diastolic depolarizationand automaticity in the Purkinje fiber networkand increases the functional refractory period relative toaction potential duration, as do procainamide and quinidine.It differs from the latter two drugs, however, in that it doesnot decrease, and may even enhance, conduction velocity and increase membrane responsiveness to stimulation.There are fewer data available on the subcellular mechanismsresponsible for the antiarrhythmic actions of lidocainethan on the more established drug quinidine. It has been proposedthat lidocaine has little effect on membrane cation exchangeof the atria. Sodium ion entrance into ventricularcells during excitation is not influenced by lidocaine becauseit does not alter conduction velocity in this area.Lidocaine hydrochloride does depress Na+ influx duringdiastole, as do all other antiarrhythmic drugs, to diminishautomaticity in myocardial tissue. It also alters membraneresponsiveness in Purkinje fibers, allowing increased conductionvelocity and ample membrane potential at the timeof excitation.

Sicherheitsprofil

Poison by ingestion, intraperitoneal, intravenous, subcutaneous, intramuscular, and intratracheal routes. Human systemic effects: somnolence, respiratory depression, low blood pressure, cardiomyopathy includmg infarction, pulse rate increase. An experimental teratogen. Other experimental reproductive effects. A skin and eye irritant. An anesthetic. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Lager

Store in a tightly closed container at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze. Keep all medications away from children and pets.

Lidocainhydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Lidocainhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 447)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252
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Shanghai Worldyang Chemical Co.,Ltd.
,+86-21-56795779; +8613651600618
sales@worldyachem.com China 879 58
Hebei Lingding Biotechnology Co., Ltd.
+86-18031140164 +86-19933155420
erin@hbldbiotech.com China 878 58
Nanjing Deda New Material Technology Co., Ltd
+8613223293093
bella@njdeda.com China 81 58
Ouhuang Engineering Materials (Hubei) Co., Ltd
+8617702722807
admin@hbouhuang.com China 1696 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12456 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 6710 58
Anhui Yiao New Material Technology Co., Ltd
+86-199-55145978 +8619955145978
sales8@anhuiyiao.com China 253 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457
salesvip2@hntmhg.com China 415 58
Xiamen Wonderful Bio Technology Co., Ltd.
+8613043004613
Sara@xmwonderfulbio.com China 305 58

73-78-9(Lidocainhydrochlorid)Verwandte Suche:


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  • Lidocaine hydrochloride CP2000,BP98
  • a-(diethylamino)-26-acetoxylidideHCl
  • a-(diethylamino)-26-acetoxylididehydrochloride
  • 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride
  • 6’-acetoxylidide,2-(diethylamino)-2hydrochloride
  • 6’-acetoxylidide,2-(diethylamino)-2monohydrochloride
  • Acetamide,2-(diethylamino)-N-(2,6-diethylphenyl)-,monohydrochloride
  • Acetamide,2-(diethylamino)-N-(2,6-dimethylphenyl)-,monohydrochloride
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  • omega-diethylamino-2,6-dimethylacetanilidehydrochloride
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  • xylestesinhydrochloride
  • xylocainehydrochloride
  • xylocard
  • xyloneural
  • xylotoxhydrochloride
  • Basicaina Monohydrate
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  • Dynexan Monohydrate
  • Heweneural Monohydrate
  • Licain Monohydrate
  • LIDOCAINE HYDROCHLORIDE ANHYDROUS USP
  • LIONCAINEHYDROCHLORIDE
  • Lidociane Hydrochloride
  • Lidocaine HCL (BP/USP)
  • Lidocaie Hydrochloride
  • 2-DIETHYLAMINO-N-(2'6'-DIMETHYLPHENYL)ACETAMIDE HCL
  • 2-DIETHYLAMINO-N-[2,6-DIMETHYLPHENYL]ACETAMIDE HCL
  • ALPHA-(DIETHYLAMINO)-2',6'-ACETOXYLIDIDE HYDROCHLORIDE
  • A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE HYDROCHLORIDE
  • Lidocaine hydrochloride 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride
  • Lidocaine hcl powder
  • Lithium Claviate
  • LIDOCAINE HYDROCHLORIDE (LIGNOCAINE HYDROCHLORIDE)
  • Lidocaine HCl CAS 73-78-9 Pharmaceutical Raw Material Lidocaine kf-wang(at)kf-chem.com
  • 99% Lidocaine Hydrochloride Pharmaceutical Raw Materials 73-78-9 Lidocaine HCl CAS NO.73-78-9
  • A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE H
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