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Dexamethason

CAS-Nr.50-02-2
Bezeichnung:Dexamethason
Englisch Name:Dexamethasone
Synonyma:Dexamethason
DXM;Dexa;Dxms;mk125;Corson;Dexone;Dezone;Hl-dex;MK 125;Auxiron
CBNumber:CB4261243
Summenformel:C22H29FO5
Molgewicht:392.46
MOL-Datei:50-02-2.mol
Dexamethason physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 262-264 °C(lit.)
alpha : 75 º (c=1, dioxane)
Brechungsindex: 76 ° (C=1, Dioxane)
Flammpunkt:: 9℃
storage temp. : 2-8°C
Löslichkeit: ethanol: 1 mg/mL
Aggregatzustand: powder
Farbe: off-white
Wasserlöslichkeit: 10 mg/100 mL (25 ºC)
Sensitive : Light Sensitive
Merck : 14,2943
BRN : 2066651
Stabilität:: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
CAS Datenbank: 50-02-2(CAS DataBase Reference)
NIST chemische Informationen: Prednisolone, 9alpha-fluoro-16alpha-methyl-(50-02-2)
EPA chemische Informationen: Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17,21-trihydroxy- 16-methyl-, (11.beta.,16.alpha.)-(50-02-2)
Sicherheit
Kennzeichnung gefährlicher: Xi,Xn,T,F
R-Sätze:: 43-40-36/37/38-20/21/22-42/43-39/23/24/25-23/24/25-11
S-Sätze:: 36/37-45-36-26-22-16
RIDADR : UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany : 2
RTECS-Nr.: TU3980000
TSCA : Yes
Giftige Stoffe Daten: 50-02-2(Hazardous Substances Data)

Dexamethason Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Dexamethasone is an Anti-inflammatory glucocorticoid that is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide.
Dexamethasone induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein in vitro. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils, but inhibits apoptosis in neutrophils in vitro. Dexamethasone is an activator of IDO.
Dexamethasone Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC?? = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase
Verwenden
Dexamethasone is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthas e.
Allgemeine Beschreibung
Odorless white to off-white crystalline powder with a slightly bitter taste.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Dexamethasone may be sensitive to prolonged exposure to light. Dexamethasone is incompatible with strong oxidizers, strong acids, acid chlorides and acid anhydrides. Oxidation may occur with bases.
Brandgefahr
Flash point data for Dexamethasone are not available; however, Dexamethasone is probably combustible.
R-Sätze Betriebsanweisung:
R43:Sensibilisierung durch Hautkontakt möglich.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S22:Staub nicht einatmen.
Biologische Aktivität
Glucocorticoid; anti-inflammatory. Reduces levels of activated NF- κ B in immature dendritic cells (DCs) and inhibits differentiation into mature DCs.
Dexamethason Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Beclometason
Dexamethason Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 246)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3230 55
Wuhan Hezhong Bio-chemical Manufacture co ltd 021-68580715 / 18930710487
nikki@pharm-china.com China 2017 55
Taizhou DongBang Fine Chemical Co. Ltd. +86-0523-86235448 15996000437
+86-0523-862354482535251509@qq.com China 48 55
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 027-65388397 18164111589
027-653883973321478047@qq.com China 1650 55
Boen pharm 86 512-62572107 62962707
86 512-62922078sales@boenpharm.com China 803 58
Shenzhen Sendi Biological Technology Co., Ltd. 订购热线:0755-23574479 手机:18124570582 (可加微信)在线QQ: 2355327139欢迎广大新老客户咨询购买
0755-23229476 QQ: 2355327139siliao02@yccreate.com China 5959 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885info@efebio.com China 1999 58
WuHan YuanCheng Gongchuang Technology Co.Ltd 027-88211053/88218372 QQ2355880512
027-88608190-969gy08@yccreate.com China 3088 55
Wuhan DKY Technology Co.,Ltd. 027-81302488 18007166089
027-81302088info@dkybpc.com;2851686510@qq.com China 1967 58
 
50-02-2(Dexamethason)Verwandte Suche:
Pregna-1,4-dien-3,20-dion, 9-Fluor-11,17-dihydroxy-16-methyl-21-[(3-sulfobenzoyl)oxy]-, Mononatriumsalz, (11β,16α)- Flumetason-21-pivalat Flumetason 9-Fluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-17-valerat 9-Fluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-(3,3-dimethylbutyrat) Fluocortolon 7α-Chlor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-17,21-di(propionat) 6α-Fluor-11β,21-dihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-hexanoat Paramethason-21-acetat Paramethason Dexamethason-21-pivalat Halometason 6α,9-Difluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-acetat 9-Fluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-21-(dihydrogenphosphat) 9-Fluor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-17,21-di(propionat) Dexamethason Dexamethasone sodium phosphate Fluor
Complex Molecules Immune Cell Signaling and Blood Immune System Regulation Immunomodulators and Antibiotics 16alpha)- 16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet 16alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-2,20-dione 16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2 16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione 16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-dien 16alpha-Methyl-9alpha-fluoro-11beta-17alpha-21-trihydroxypregna-1,4-diene-3,20-dione 16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol 16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol 16-alpha-methyl-9-alpha-fluoro-delta(sup1)-hydrocortisone 16alpha-Methyl-9alpha-fluoro-delta(sup1)-hydrocortisone 16alpha-methyl-9alpha-fluoro-delta1-hydrocortisone 16-alpha-methyl-9-alpha-fluoroprednisolone 16alpha-Methyl-9alpha-fluoroprednisolone 17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-9-alpha-fluoro-11-bet 17-alpha,21-triol-3,20-9-alpha-fluoro-16-alpha-methyl-4-pregnadiene-11-beta 1-dehydro-16alpha-methyl-0alpha-fluorohydrocortisone 1-dehydro-16-alpha-methyl-9-alpha-fluorohydrocortisone 1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone 3,20-dione. 4-alpha-fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20 4-alpha-fluoro-16-alpha-methyl-11-beta,17,21-trihydroxypregna-1,4-diene-3,20-d 4alpha-Fluoro-16alpha-methyl-11beta-17,21-trihydroxypregna-1,4-diene-3,20-dione 4-diene-3,20-dione,9-fluoro-11,17,21-trihydroxy-16-methyl-,(11.beta.,16.alpha.)-Pregna-1 6alpha)- 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-dien 9alpha-Fluoro-11beta-17alpha- 21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 9-alpha-fluoro-16-alpha-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2 9alpha-Fluoro-16alpha-methyl-1,4-pregnadiene-11beta-17-alpha-21-triol-3,20-dione 9alpha-Fluoro-16alpha-methyl-11beta,17alpha,21beta-trihydroxy-pregna-1,4-diene-3,20-dione Aeroseb-D Aeroseb-Dex anaflogistico Aphtasolon Auxiron Bisu DS component of Azimycin component of Azium component of Deronil component of Dronactin Corson Corsone Cortisumman Decaderm Decadron Tablets, Elixir decalix Decaspray Dekacort delta(sup1)-9-alpha-fluoro-16-alpha-methylcortisol delta1-9-alpha-Fluoro-16-alpha-methylcortisol Deltafluorene Dergramin Desadrene Desametasone
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