Dibenz[a,h]anthracen Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSES KRISTALLINES PULVER.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Möglich sind Auswirkungen auf die Haut mit nachfolgender Photosensibilisierung. Wahrscheinlich krebserzeugend für den Menschen.
LECKAGE
Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P3-Filter für giftige Partikel.
R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
R38:Reizt die Haut.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.
Beschreibung
1, 2:5, 6-DIBENZANTHRACENE is a crystalline aromatic hydrocarbon. It is a component of coal tars, shale oils, and soots (IARC, 1985) and has been detected in gasoline engine exhaust, coke oven emissions, cigarette smoke, charcoal broiled meats, vegetation near heavily traveled roads, and surface water and soils near hazardous waste sites. It is a kind of carcinogenic compound, and thus being mainly used for the research purpose. For example, in biological research, it is a mutagen used to induce tumorigenesis.
Chemische Eigenschaften
Dibenz[a,h]anthracene is a white crystalline solid.
It is insoluble in water, slightly soluble in alcohol, and
soluble in ether. This compound is incompatible with strong
oxidizers.
Physikalische Eigenschaften
Colorless to pale yellow, monoclinic or orthorhombic crystals which with a faint, pleasant odor.
Verwenden
Dibenz[a,h]anthracene is a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Dibenz[a,h]anthracene has produced positive results in bacterial DNA damage and mutagenicity assays and in mammalian cell DNA damage, mutagenicity and cell transformation assays.
Vorbereitung Methode
There is no commercial production or known use of this
compound. It has been isolated from the coal tar pitch and
is found in coke over effluents. It has been detected in
urban atmospheres and occurs in tobacco smoke. Dibenz
[a,h]anthracene is present as a minor component of the
total PAH content in the environment. Human exposure
occurs through smoking, inhaling of polluted air, and by
ingesting food and water containing combustion
products.
Allgemeine Beschreibung
White crystals or pale yellow solid. Sublimes.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
1,2:5,6-DIBENZANTHRACENE is incompatible with strong oxidizing agents. Is oxidized by chromic acid and by osmium tetraoxide .
Health Hazard
The toxicity of dibenz[a,h]anthracene is onthe same order as that of benz[a]anthracene.A lethal dose in mice by intravenous routeis 10 mg/kg. There is no report on its oraltoxicity. It is a mutagen. Its carcinogenicityin animals is well established, causing cancersin the lungs, liver, kidney, and skin.
Brandgefahr
Flash point data for 1,2:5,6-DIBENZANTHRACENE are not available; however, 1,2:5,6-DIBENZANTHRACENE is probably combustible.
Sicherheitsprofil
Confirmed carcinogen
with experimental carcinogenic,
tumorigenic, and neoplastigenic data. Poison
by intravenous route. Human mutation data
reported. When heated to decomposition it
emits acrid smoke and irritating fumes.
mögliche Exposition
Dibenz(a,h)anthracene is a chemical
substance formed during the incomplete burning of fossil
fuel, garbage, or any organic matter and is found in smoke
in general; it condenses on dust particles and is distributed
into water and soil and on crops. DB(a,h)A is a PAH and
is also a component of coal tar pitch, which is used
in industry as a binder for electrodes, and creosote is used
to preserve wood. PAHs are also found in limited amounts
in bituminous materials and asphalt used in industry and
for paving.
Carcinogenicity
Based on no human data and
sufficient data from animal assays, IRIS classifies dibenz
[a,h]anthracene as a B2 carcinogen, a probable human
carcinogen, and the IARC classifies dibenz[a,h]anthracene
as a 2A carcinogen. Dibenz[a,h]anthracene produced
carcinomas in mice following oral or dermal administration
and injection site tumors in several species following s.c.
or i.m. injection. It is also a tumor initiator.
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN3077 Environmentally hazardous substances,
solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous
hazardous material, Technical Name Required.
läuterung methode
The yellow-green colour (due to other pentacyclic impurities) is removed from it by crystallising from *benzene or by selective oxidation with lead tetraacetate in acetic acid [Moriconi et al. J Am Chem Soc 82 3441 1960]. [Beilstein 5 IV 2722.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explo-
sions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, and epoxides.
Waste disposal
See the entry on Coal Tar
Pitch Volatiles. Consult with environmental regulatory
agencies for guidance on acceptable disposal practices.
Generators of waste containing this contaminant (≥100 kg/
mo) must conform with EPA regulations governing storage,
transportation, treatment, and waste disposal.
Einzelnachweise
https://pubchem.ncbi.nlm.nih.gov/compound/Dibenz_a_h_anthracene#section=Top
Heidelberger, Charles, and H. B. Jones. "The Distribution of Radioactivity in the Mouse Following Administration of Dibenzanthracene Labeled in the 9 and 10 Positions with Carbon Fourteen." Cancer1.2(2010):252.
https://rais.ornl.gov/tox/profiles/dibenz_a_h_anthracene_c_V1.html
Dibenz[a,h]anthracen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
