β-Boswellic Acid
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- CAS-Nr.
- 631-69-6
- Englisch Name:
- β-Boswellic Acid
- Synonyma:
- BRN0077366;Masticinic acid;B-BOSWELLIC ACID;Β-BOSWELLIC ACID;β-Boswellic Acid;BOSWELLIC ACID, B-;BETA-BOSWELLIC ACID;BOSWELLIC ACID, a-(P);β-Boswellic Acid USP/EP/BP;NBGQZFQREPIKMG-PONOSELZSA-N
- CBNumber:
- CB4427357
- Summenformel:
- C30H48O3
- Molgewicht:
- 456.71
- MOL-Datei:
- 631-69-6.mol
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β-Boswellic Acid Eigenschaften
- Schmelzpunkt:
- 130-135°C
- alpha
- D +107° (c = 0.75 in CHCl3)
- Siedepunkt:
- 556.0±50.0 °C(Predicted)
- Dichte
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka
- 4.50±0.70(Predicted)
- Farbe
- Off-White
- Wasserlöslichkeit
- practically insoluble in water
- InChIKey
- NBGQZFQREPIKMG-AKOQEMLPSA-N
- LogP
- 9.105 (est)
- CAS Datenbank
- 631-69-6
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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β-Boswellic Acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
β-Boswellic acid is a pentacyclic triterpene originally isolated from
Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC
50 value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC
50 values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC
50 = 8 μM).
Chemische Eigenschaften
BETA-BOSWELLIC ACID is Off-White Solid
Verwenden
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).
β-Boswellic Acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
β-Boswellic Acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 178)Lieferanten
631-69-6()Verwandte Suche:
- BETA-BOSWELLIC ACID
- B-BOSWELLIC ACID
- BOSWELLIC ACID, B-
- Beta-BoswellicAcidforU.Lingner-HoffmannCHEMOSGmbHsales
- (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid
- BOSWELLIC ACID, a-(P)
- (3A,4B)-3-HYDROXYURS-12-EN-23-OIC ACID
- (3a,4)-3-Hydroxyurs-12-en-23-oic Acid
- (3α,4β)-3-Hydroxyurs-12-en-23-oic Acid
- 3-Hydroxy-12-ursen-24-oic acid
- 3α-Hydroxyurs-12-en-24-oic acid
- Β-BOSWELLIC ACID
- NBGQZFQREPIKMG-PONOSELZSA-N
- Soluble BOSWELLIC ACID, Liposomal BOSWELLIC ACID, BOSWELLIC ACID NanoEmulsion, NanoActive BOSWELLIC ACID, BETA-BOSWELLIC ACID,Boswellia sacra
- Soluble BOSWELLIC ACID, Liposomal BOSWELLIC ACID, BOSWELLIC ACID NanoEmulsion, NanoActive BOSWELLIC ACID, BETA-BOSWELLIC ACID
- Urs-12-en-23-oic acid, 3-hydroxy-, (3α,4β)-
- β-Boswellic Acid USP/EP/BP
- Masticinic acid
- BRN0077366
- β-Boswellic Acid
- Urs-12-en-23-oic acid, 3-hydroxy-, (3α,4β)-
- 631-69-6
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Miscellaneous Natural Products
