Doxifluridin
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- CAS-Nr.
- 3094-09-5
- Bezeichnung:
- Doxifluridin
- Englisch Name:
- Doxifluridine
- Synonyma:
- flutron;5'-DFUR;5'DFURD;furtulon;AMC 0101;5-F-5‘-dU;RO-21-9738;5-cl-5'-dU;Doxifluidine;DOXIFLURIDINE
- CBNumber:
- CB4461786
- Summenformel:
- C9H11FN2O5
- Molgewicht:
- 246.19
- MOL-Datei:
- 3094-09-5.mol
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Doxifluridin Eigenschaften
- Schmelzpunkt:
- 188-192 °C(lit.)
- alpha
- D25 +18.4° (c = 0.419 in water)
- Dichte
- 1.3751 (estimate)
- Brechungsindex
- 20 ° (C=1, H2O)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 7.4(at 25℃)
- Farbe
- White
- Merck
- 14,3437
- CAS Datenbank
- 3094-09-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
26-36-24/25 |
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| WGK Germany |
2 |
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| RTECS-Nr. |
YU7526000 |
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| Hazard Note |
Irritant |
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| HazardClass |
IRRITANT, IRRITANT-HARMFUL |
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| HS Code |
29349990 |
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| Toxizität |
LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P272 |
Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Doxifluridin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is
more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemische Eigenschaften
White Solid
Verwenden
An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
Definition
ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro
racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
Doxifluridin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Doxifluridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 344)Lieferanten
3094-09-5(Doxifluridin)Verwandte Suche:
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-quinone
- Capecitabine Related Compound B (20 mg) (5'-deoxy-5-fluorouridine)
- 5μdFUrd, Doxifluridine
- 5μdFUrd, 5-Fluoro-5μ-deoxyuridine
- 5’-Deoxy-5-fluomuridine
- 2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-
- 5Urd, 5-Fluoro-5deoxyuridine
- URIDINE,5''-DEOXY-5-FLUORO
- 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl]-5-fluoropyrimidine-2,4(1h,3h)-dione
- flutron
- furtulon
- Doxifluridine 3094-9-5
- 1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
- 5’dUrd, 5-Fluoro-5’-deoxyuridine, 5’-DFUR, Doxifluridine
- 5'-dFUrd
Doxifluridine
1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
- Doxifluridine(Ro 21-9738)
- CAPECITABINE related substance USP B
- RO-21-9738
- (+)-5-FLUORO-5'-DEOXYURIDINE
- 5-FLUORO-5'-DEOXYURIDINE
- 5'-DEOXY-5-FLUOROURIDINE
- 5'-DEOXYFLUOROURIDINE
- 5'-DFUR
- 5'DFURD
- DOXIFLURIDINE
- MURINE RECOMBINANT
- Doxifluridine (furtulon)
- DOXIFLUIRDINE
- 5'-Deoxy-fluorouridine(DFUR)/Doxifluridine
- (+)-5-FLUORO-5'-DEOXYURIDINE 97%
- 5-FLURO-5’-DEOXYURIDINE
- 5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738
- Doxifluidine
- DOXIFLURIDINE(SUBJECTTOPATENTFREE)
- (+)-5-Fluoro-5'-deoxyuridine98%
- 5-Fluorodesoxyuridine
- Uridine, 5'-deoxy-5-fluoro- (8CI, 9CI)
- 5-FLUORO-5''-DEOXYURIDINE / DOXIFLURIDINE / 5''-DEOXY-FLUOROURIDINE
- (+)-Doxifluridine, (+)-1-(beta-D-5'-Deoxyribofuranosyl)-5-fluorouracil
- 5-F-5‘-dU
- 5'-DFUR-13C5 (5'-Deoxy-5-fluorouridine, Doxifluridine-13C5)
- AMC 0101
- 5-cl-5'-dU
- Doxifluridine, >=98.5%
- Capecitabine USP RC B
- Doxifluridine Doxifluridine
- 5’-deoxy-5-fluoro-uridin
- Doxifluridine/5-Fluoro-5′-deoxyuridine
- Capecitabine Impurity 16（Capecitabine EP Impurity B）
- 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-2-oxolanyl]-5-fluoropyrimidine-2,4-dione
- Capecitabine Impurity B
- 5'-Deoxy-5-fluorouridine>
- Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)
- 5’-deoxy-5-fluorouridine, Doxifluridine 5'-DFUR
- Doxifluridine USP/EP/BP
- Capecitabine EP Impurity B/ Capecitabine Related Compund B (Doxifluridine/ Deoxy-5-fluorouridine)
