ILOPERIDONE

ILOPERIDONE Struktur
133454-47-4
CAS-Nr.
133454-47-4
Englisch Name:
ILOPERIDONE
Synonyma:
HP 873;Fanapt;CS-270;ZoMaril;Fanapta;Eponidone;loperidone;ILOPERIDONE;20MG/100MG/1KG;Iloperidone-P88
CBNumber:
CB4772066
Summenformel:
C24H27FN2O4
Molgewicht:
426.48
MOL-Datei:
133454-47-4.mol

ILOPERIDONE Eigenschaften

Schmelzpunkt:
118-120°C
Siedepunkt:
593.7±50.0 °C(Predicted)
Dichte
1.204±0.06 g/cm3(Predicted)
Flammpunkt:
9℃
storage temp. 
-20°C
Löslichkeit
DMSO: soluble5mg/mL, clear
Aggregatzustand
powder
pka
8.43±0.20(Predicted)
Farbe
white to beige
Merck 
14,4900
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,T
R-Sätze: 11-23/24/25-39/23/24/25
S-Sätze: 16-36/37-45
RIDADR  UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany  1
RTECS-Nr. KM5777850
HS Code  29349990
Giftige Stoffe Daten 133454-47-4(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H413 Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 4
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

ILOPERIDONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Iloperidone is an atypical antipsychotic and adrenergic, dopamine, and serotonin (5-HT) receptor antagonist. It binds to several receptors, including the α1-adrenergic receptor (α1-AR), α2-AR, and dopamine D2 receptor (Kis = 0.31, 3, and 3.3 nM, respectively), as well as the 5-HT1A, 5-HT1D, 5-HT2A, and 5-HT2C receptors (Kis = 33, 15, 0.2, and 14 nM, respectively) in radioligand binding assays using human post-mortem brain tissue. Iloperidone also binds to human D1, D3, D4, D5, and rat 5-HT2 receptors (Kis = 216, 7.1, 25, 319, and 3.1 nM, respectively, in CHO cells) and the histamine H1 receptor (Ki = 12.3 nM in human post-mortem brain tissue). Iloperidone (1-3 mg/kg) prevents the reduction in prepulse inhibition induced by apomorphine , phencyclidine (PCP), and cirazoline in rats. It also increases the time rats spend in the open arms of the elevated plus maze and the number of social interactions when administered at a dose of 0.5 mg/kg. Formulations containing iloperidone have been used in the treatment of schizophrenia.

Chemische Eigenschaften

Off-White Solid

Verwenden

Iloperidone (Fanapt, Fanapta, Zomaril) is an atypical antipsychotic for the treatment of schizophrenia. Iloperidone is a monoamine directed towards acting upon and antagonizing specific neurotransmitters, particularly multiple dopamine and serotonin recep

Definition

ChEBI: A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation a tipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia.

Allgemeine Beschreibung

Iloperidone is an atypical antipsychotic administered for the treatment of schizophrenia. The drug is marketed under the trade names Fanapt and Fanapta. This Certified Spiking Solution? is suitable for use in LC/MS or GC/MS applications including clinical toxicology, forensic testing, or pharmaceutical research.

Clinical Use

Acting as an antagonist on serotonin (5-HT2) and dopamine receptor subtypes, iloperidone is an antipsychotic indicated for the treatment of acute schizophrenia in adults. Based on its in vitro and in vivo binding properties against both serotonin and dopamine receptors, it is expected that iloperidone will show fewer extrapyramidal symptoms than currently marketed antipsychotics such as haloperidol and clozapine. The original discovery was made by Hoechst-Roussel Pharmaceuticals who passed the developing rights to Vanda Pharmaceuticals and subsequently Novartis for marketing in the U.S. and Canada. While this drug was originally approved in the U.S. in 2009, the marketing was only initiated in the U.S. in 2010.

ILOPERIDONE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ILOPERIDONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 350)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 14936 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 295 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58

133454-47-4()Verwandte Suche:


  • ILOPERIDONE
  • 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
  • Iloperidone(Fanapt)
  • 20MG/100MG/1KG
  • 1-(4-(3-(4-(6-fluorobenzo[d]isoxazol-4-yl)piperidin-1-yl)propoxy)-3-Methoxyphenyl)ethanone
  • Iloperidone-P88
  • Fanapt
  • HP 873
  • ZoMaril
  • Iloperidone(ILO-522,HP-873)
  • 1-(4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methoxyphenyl)ethanone
  • Iloperidone P88 metabolite-13DD3 (Racemic)
  • Iloperidone 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
  • loperidone 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
  • Iloperidone solution
  • 1,2-Benzisoxazole,ethanone deriv.
  • 4'-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone
  • loperidone
  • Iloperidone (HP-873)
  • CS-270
  • Iloperidone >
  • Ethanone, 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-
  • 1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-(trideuteriomethoxy)phenyl]ethanone
  • ILOPERIDONE USP/EP/BP
  • IloperidoneQ: What is Iloperidone Q: What is the CAS Number of Iloperidone Q: What are the applications of Iloperidone
  • TIANFU-CHEM - ILOPERIDONE
  • Iloperidone (1336249)
  • Eponidone
  • Carbamicacid,N-(2-bromoethyl)-N-methyl-,1,5-dimethylethylester
  • Fanapta
  • 133454-47-4
  • C24H27FN2O4
  • Fanapta, Zomaril
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • APIS
  • Iloperidone
  • API
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