Pirfenidone
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- CAS-Nr.
- 53179-13-8
- Englisch Name:
- Pirfenidone
- Synonyma:
- 5-methyl-1-phenylpyridin-2(1H)-one;5-Methyl-1-phenylpyridine-2(1H)-one;Pirespa;Pirfenidone CRS;5-METHYL-1-PHENYL-2-(1H)-PYRIDONE;S-7701;amr-69;PIRFENIDONE;PIRFINIDONE;S-7701,AMR-69
- CBNumber:
- CB5299210
- Summenformel:
- C12H11NO
- Molgewicht:
- 185.22
- MOL-Datei:
- 53179-13-8.mol
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Pirfenidone Eigenschaften
- Schmelzpunkt:
- 96-97°C
- Siedepunkt:
- 329.1±15.0 °C(Predicted)
- Dichte
- 1.137±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO: ≥10 mg/mL, soluble
- Aggregatzustand
- solid
- pka
- -0.16±0.63(Predicted)
- Farbe
- Off-white
- Wasserlöslichkeit
- Soluble to 20 mM in water
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChI
- InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
- InChIKey
- ISWRGOKTTBVCFA-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C2=CC=CC=C2)C=C(C)C=C1
- CAS Datenbank
- 53179-13-8(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Pirfenidone Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Until recently, IPF therapy consisted of a combination of corticosteroids
and immunosuppressive agents (azathioprine and cyclophosphamide)
to target the inflammation that was believed to be the pathogenic
stimulus.Since IPF is now considered to be predominantly a disorder of
fibroproliferation, agents that intervene in fibrogenesis have moved
to the forefront of treatment options. With demonstrated efficacy in a
bleomycin-induced lung fibrosis animal model, pirfenidone has been
developed and launched as an approved therapy for IPF. Its antifibrotic activity is derived from the inhibition of p38 MAP kinase that is
upstream of transforming growth factor-β (TGF-β), a cytokine implicated
in the stimulation of collagen synthesis and the inhibition of its
degradation. Pirfenidone also inhibits the expression of TNF-α, IL-1,
and ICAM-1, so it possesses the dual benefit of an anti-inflammatory and
antifibrotic agent. This relatively simplistic drug is constructed by the copper-catalyzed reaction of 5-methyl-2(1H)-pyridinone with bromo- or chlorobenzene.
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Chemische Eigenschaften
Off-White Solid
Verwenden
Pirfenidone is in a group of medicines called antifibrotic agents. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It affects your body’s immune system and reduces the amount of fibrosis (scarring) in the lungs. Pirfenidone is one of two medicines that are approved in Canada to treat Idiopathic Pulmonary Fibrosis (IPF). Another name for this medicine is Esbriet.
Definition
ChEBI: A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Allgemeine Beschreibung
Pirfenidone?(5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.
Biologische Aktivität
Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.
Pirfenidone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pirfenidone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 604)Lieferanten
53179-13-8()Verwandte Suche:
Methylacrylat
2,6-Dimethylpyridin
2,4,6-Trimethylpyridin
Methyl-4-hydroxybenzoat
Kresoxim-methyl
2-Chloro-5-chloromethylpyridine
Sorafenib tosylate
Trazodon
Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink
Cefoperazon
4-Methylpyridin
Chlordimethylphenylsilan
Cefoperazone sodium +sulbactam sodium(1:1/2:1)
Azamethiphos
Phenylvalerat
5-Thia-1-azabicyclo[4.2.0]oct-2-en-2-carbonsure, 7-[[[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino](4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, Mononatriumsalz, [6R-[6α,7β(R*)]]-
2,4'-Dimethyl-3-piperidinopropiophenonhydrochlorid
Thiophanat-methyl
- S-7701
- 5-methyl-1-phenyl-2-pyridone
- 5-methyl-1-phenyl-pyridin-2-one
- 5-methyl-1-phenylpyridin-2-one
- Pirfenidone, >=99%
- Pirfenidone(S-7701,AMR-69)
- 2(1H)-Pyridinone,5-Methyl-1-phenyl-
- Pirfenidone ( 5-Methyl-1-Phenyl-2(1H)-Pyridinone)
- Pirfenidone SynonyMs 5-Methyl-1-phenyl-2-(1H)-pyridone
- S-7701,AMR-69
- 5-methyl-1-phenyl-2(1h)-pyridon
- amr-69
- PIRFENIDONE
- 5-METHYL-1-PHENYL-1H-PYRIDIN-2-ONE
- 5-METHYL-1-PHENYL-2(1H)-PYRIDINONE
- 5-Methyl-N-phenyl-2-1H-pyridone
- Pirfenidone also see 5-Methyl-1-Phenyl-2(1H)-Pyridinone
- TORASEMIDETECHPIRFENIDONE
- 5-Methyl-N-phenyl-2-1H-pyridone [Pirfenidone]
- Pirfenidone(AMR-69)
- Pirfenidone, 98%, an inhibitor for TGF-β production and TGF-β stimulated collagen
- pirfenidone price
- 5-Methyl-1-phenyl-2-pyridinone
- Pirfenidone>
- Pirfenidone USP/EP/BP
- 2-Amino-7-picoline
- PirfenidoneQ: What is
Pirfenidone Q: What is the CAS Number of
Pirfenidone Q: What is the storage condition of
Pirfenidone
- 5-Methyl-1-phenylpyridine-2(1H)-one
- Pirespa
- 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE
- Pirfenidone CRS
- 5-methyl-1-phenylpyridin-2(1H)-one
- PIRFINIDONE
- Pirfenidone
5-methyl-1-phenylpyridin-2(1H)-one
- Pirfenidone (S-7701)
- 53179-13-8
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Immunomodulators and Antibiotics
- Immune Cell Signaling and Blood
- Immune System Regulation
- Cytokine signaling
- Inhibitors
- Smad
- TGF-beta
- Aromatics Compounds
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 53179-13-8
