Magnesiumdistearat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
WEISSES PULVER.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich. Die trockene Substanz kann durch Verwirbeln, Druckluft, Fließen usw. elektrostatisch aufgeladen werden.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung reizender Rauche.
ARBEITSPLATZGRENZWERTE
TLV:(als Stearat) 10 mg/m?(als TWA) Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation.
INHALATIONSGEFAHREN
Eine belästigende Partikelkonzentration in der Luft kann beim Dispergieren schnell erreicht werden.
LECKAGE
Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel.
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Magnesium stearate, also called octa decanoic acid, magnesium salt, is a white substance, powder which becomes solid at room temperature. It has the chemical formula Mg(C
18H
35O
2)
2. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate melts at about 120 °C, is not soluble in water, and is generally considered safe for human consumption at levels below 2500 mg/kg per day.In 1979, the FDA's Subcommittee on GRAS (generally recognized as safe) Substances (SCOGS) reported, "There is no evidence in the available information on ... magnesium stearate ... that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future.".
Chemische Eigenschaften
Magnesium stearate is a very fine, light white, precipitated or milled, impalpable powder of low bulk density, having a faint odor of stearic acid and a characteristic taste. The powder is greasy to the touch and readily adheres to the skin. nonflammable used in baby dusting powder(s) and as tablet lubricant.
Verwenden
Magnesium Stearate is the magnesium salt of stearic acid which
functions as a lubricant, binder, emulsifier, and anticaking agent. it
is a white powder that is insoluble in water. it is used as a lubricant
or die release in tableting pressed candies and is also used in sugar-
less gum and mints.
Vorbereitung Methode
Magnesium stearate is prepared either by the interaction of aqueous
solutions of magnesium chloride with sodium stearate or by the
interaction of magnesium oxide, hydroxide, or carbonate with
stearic acid at elevated temperatures.
synthetische
Magnesium stearate is created by the reaction of sodium stearate with magnesium sulfate.
Definition
Mg(C18H35O2)2 or with one H2O.
Technical grade contains small amounts of the
oleate and 7% magnesium oxide, MgO.
Allgemeine Beschreibung
Magnesium stearate (Mg-St) is the magnesium salt of stearic acid. Its anhydrate, dihydrate and trihydrate forms have been prepared. The tabletting of the blends of magnesium stearate and lactose granules has been described. The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined. Mg-St is widely used lubricant in pharmaceutical industry. It also plays a role in delaying the process of dissolution. Its detection in tablets by laser-induced breakdown spectroscopy has been proposed.
Pharmazeutische Anwendungen
Magnesium stearate is widely used in cosmetics, foods, and
pharmaceutical formulations. It is primarily used as a lubricant in
capsule and tablet manufacture at concentrations between 0.25%
and 5.0% w/w. It is also used in barrier creams.
Sicherheitsprofil
Slightly toxic by
ingestion. Spontaneously combustible.
When heated to decomposition it emits
acrid smoke and toxic fumes.
Sicherheit(Safety)
Magnesium stearate is widely used as a pharmaceutical excipient
and is generally regarded as being nontoxic following oral
administration. However, oral consumption of large quantities
may produce a laxative effect or mucosal irritation.
No toxicity information is available relating to normal routes of
occupational exposure. Limits for heavy metals in magnesium
stearate have been evaluated in terms of magnesium stearate worstcase
daily intake and heavy metal composition.
Toxicity assessments of magnesium stearate in rats have
indicated that it is not irritating to the skin, and is nontoxic when
administered orally or inhaled.
Magnesium stearate has not been shown to be carcinogenic
when implanted into the bladder of mice.
LD
50 (rat, inhalation): >2 mg/L
LD
50 (rat, oral): >10 g/kg
Lager
Magnesium stearate is stable and should be stored in a well-closed
container in a cool, dry place.
Inkompatibilitäten
Incompatible with strong acids, alkalis, and iron salts. Avoid mixing
with strong oxidizing materials. Magnesium stearate cannot be used
in products containing aspirin, some vitamins, and most alkaloidal
salts.
Regulatory Status
GRAS listed. Accepted as a food additive in the USA and UK.
Included in the FDA Inactive Ingredients Database (oral capsules,
powders, and tablets; buccal and vaginal tablets; topical preparapreparations;
intravitreal implants and injections). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List
of Acceptable Non-medicinal Ingredients. Listed on the US TSCA
inventory.
Magnesiumdistearat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
