2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin

Chlorpromazine Struktur
50-53-3
CAS-Nr.
50-53-3
Bezeichnung:
2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin
Englisch Name:
Chlorpromazine
Synonyma:
Clorpromazina;Chloropromazine;Thorazine;Chlorpromazin;Prozin;Prazil;2601-A;Esmind;Elmarin;Hibanil
CBNumber:
CB5547531
Summenformel:
C17H19ClN2S
Molgewicht:
318.86
MOL-Datei:
50-53-3.mol

2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin Eigenschaften

Schmelzpunkt:
56.5°C
Siedepunkt:
bp0.8 200-205°
Dichte
1.1644 (rough estimate)
Brechungsindex
1.6230 (estimate)
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
pka
pKa 9.3(H2O,t =24±1) (Uncertain)
Aggregatzustand
Solid
Farbe
White to Off-White
NIST chemische Informationen
Chlorpromazine(50-53-3)
EPA chemische Informationen
Chlorpromazine (50-53-3)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Giftige Stoffe Daten 50-53-3(Hazardous Substances Data)
Toxizität LD50 oral in rat: 142mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

This phenothiazine with sedative properties is used in human medicines and has induced contact dermatitis in nurses or in those working in the pharmaceutical industry. It is also used in veterinary medicine to avoid mortality of pigs during transportation. It is a sensitizer and a photosensitizer.

Chemische Eigenschaften

Oily liquid; amine odor.

Verwenden

In psychiatric practice, chlorpromazine is used in various conditions of psychomotor excitement in patients with schizophrenia, chronic paranoid and also manic-depressive conditions, neurosis, alcohol psychosis and neurosis accompanied by excitement, fear, stress, and insomnia. In comparison with other neuroleptics, chlorpromazine is unique in that it has an expressed sedative effect. It is sometimes used in anesthesiological practice for potentiating narcosis. It also has moderate anticonvulsant action.

Definition

ChEBI: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.

Hazard

Toxic by ingestion.

Kontakt-Allergie

This phenothiazine with sedative properties is used in human medicine and induced contact dermatitis in nurses or those working in the pharmaceutical industry. It is also used in veterinary medicine to avoid mortality of pigs during transportation. It is a sensitizer and a photosensitizer.

Environmental Fate

Acute and chronic toxicity due to chlorpromazine generally manifests as an extension of normal pharmacological activity. The precise mechanism of action of chlorpromazine, and other phenothiazines, is unknown; however, it is thought to primarily involve antagonism of dopaminergic (D2) neurotransmission at synaptic sites and blockade of postsynaptic dopamine receptor sites at the subcortical levels of the reticular formation, limbic system, and hypothalamus. This activity contributes to chlorpromazine’s extrapyramidal reactions. Chlorpromazine also has strong central and peripheral activity directed against adrenergic receptors and weak activity against serotonergic, histaminic (H1), and muscarinic receptors. Chlorpromazine has slight ganglionic blocking action. Chlorpromazine is known to depress vasomotor reflexes medicated by the hypothalamus and/or brain stem; inhibit release of growth hormone; antagonize secretion of prolactin release-inhibiting hormone; and reduce secretion of corticotropin-regulatory hormone.
Chlorpromazine also has direct effects on cardiac myocytes; it can induce early after-depolarizations, block depolarizing sodium channels, and cause significant prolongation of the QTc interval.
Chlorpromazine may be irritating to eyes, mucous membranes, and skin. Contact and inhalation should be avoided.

Stoffwechselwegen

The in vivo photodegradation of chlorpromazine in rat skin exposed to UV-A results in the formation of promazine and 2-hydroxypromazine in irradiated rats, but not in the skin of rats kept in the dark. Chlorpromazine sulfoxide is a major metabolite of chlorpromazine, found in smaller quantity in the skin of irradiated rats compared with those kept in the dark. Chlorpromazine sulfoxide is not a photoproduct of chlorpromazine under the experimental conditions.

2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 119)Lieferanten
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Xiamen Wonderful Bio Technology Co., Ltd.
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Dayang Chem (Hangzhou) Co.,Ltd.
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50-53-3(2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin)Verwandte Suche:


  • Novomazina
  • Phenactyl
  • Phenathyl
  • Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]-
  • Plegomasine
  • Prazil
  • Prazilpromactil
  • Propaphenin
  • Prozin
  • Psychozine
  • SKF 2601-A
  • SKF-2601
  • Thiazenone
  • Torazina
  • 3-(2-chlorophenothiazin-10-yl)propyldimethylamine
  • CHLORPROMAZINE,USP
  • CHLORPROMAZINE(ALKALI)
  • Chlorpromazine (base and/or unspecified salts)
  • 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
  • Chlorpromazine
  • 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
  • 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
  • 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-
  • 2601-A
  • 2-Chloro-10-[3-(dimethyamino)propyl]phenothiazine
  • 2-Chloropromazine
  • 2-Cloro-10 (3-dimetilaminopropil)fenotiazina
  • 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine
  • 4560 R.P.
  • Aminasine
  • Aminazin
  • Aminazine
  • Ampliactil
  • Amplicitil
  • Amplictil
  • Chlorderazin
  • Chloro-2-dimethylamino-3 propyl-10 phenothiazine
  • Chlorpromados
  • Chlor-Promanyl
  • Chlor-PZ
  • Contomin
  • Cromedazine
  • Elmarin
  • Esmind
  • Fenactil
  • Fenaktyl
  • Fraction AB
  • Hibanil
  • Hibernal
  • HL 5746
  • Largactilothiazine
  • Largactyl
  • 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidinyl)-6-pyrimido[5,4-d]pyrimidinyl]-(2-hydroxyethyl)amino]ethanol
  • [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine
  • ChlorpromazineQ: What is Chlorpromazine Q: What is the CAS Number of Chlorpromazine Q: What is the storage condition of Chlorpromazine Q: What are the applications of Chlorpromazine
  • Thorazine
  • Chloropromazine
  • Chlorpromazin
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