Methazolamid

Methazolamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Methazolamide is a carbonic anhydrase inhibitor (IC₅₀ = 130 nM). It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. Methazolamide reduces electroshock-induced seizures in rats with an ED₅₀ value of 19.2 mg/kg. It also inhibits production of reactive oxygen species (ROS) in a primary cortical neuron (PCN) cellular model of subarachnoid hemorrhage (SAH) and reduces cerebral edema in a mouse model of SAH. Methazolamide is larvicidal, with a larvicidal concentration (LC₅₀) value of 724 ppm, but has no activity when administered in the diet to adult A. aegypti. Formulations containing methazolamide have been used for the treatment of glaucoma.

Chemische Eigenschaften

White Solid

Verwenden

Methazolamide is a carbonic anhydrase inhibitor. Methazolamide is used in the treatment of glaucoma.

Clinical Use

Methazolamide is a derivative of acetazolamide in which one of the active hydrogens has been replaced by a methyl group. This decreases the polarity and permits a greater penetration into the ocular fluid, where it acts as a carbonic anhydrase inhibitor, reducing intraocular pressure. Its dose for glaucoma is 50 to 100 mg two to three times a day.

Methazolamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Methazolamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3632	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58

554-57-4(Methazolamid)Verwandte Suche:

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• 2-acetylimino-3-methyl-delta(sup4)-1,3,4-thiadiazoline-5-sulfonamide
• 2-Acetylimino-3-methyl-delta⁴-1,3,4-thiadiazoline-5-sulfonamide
• 5-acetylimino-4-methyl-delta(sup2)-1,3,4-thiadiazoline-2-sulfonamide
• CL 8490
• N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
• N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
• N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)ethanamide
• Methazolamide (500 mg)
• MethazolaMide, USP
• 5-AcetyliMino-4-Methyl-Δ2-1,3,4-thiadiazoline-2-sulfonaMide
• L 584601
• Neptaza
• n-(4-methyl-2-sulfamoyl-△2-1,3,4-thiadiazolin-5-ylidene) acetamide
• N-[(2E)-5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
• (E)-N-(3-Methyl-5-sulfaMoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetaMide
• Methazolamide≥ 98% (HPLC)
• Carbonic Anhydrase IX Inhibitor III, Methazolamide
• Mathazolamide
• Methazolamide, >=99%
• 5-Acetylimino-4-methyl-delta²-1,3,4-thiadiazoline-2-sulfonamide
• Acetamide, N-(4-methyl-2-sulfamoyl-delta²-1,3,4-thiadiazolin-5-ylidene)-
• Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-
• Methenamide
• N-((2Z)-5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
• n-(4-methyl-2-sulfamoyl-delta(2)-1,3,4-thiadiazolin-5-ylidene)-acetamid
• n-(4-methyl-2-sulfamoyl-delta(sup2)-1,3,4-thiadiazolin-5-ylidene)-acetamid
• N-(4-Methyl-2-sulfamoyl-delta²-1,3,4-thiadiazolin-5-ylidene)acetamide
• n-(5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3h)-ylidene)-acetamid
• Naptazane
• Neptazane
• Neptazaneat
• METHAZOLAMIDE
• N-[4-METHYL-2-SULFAMOYL-DELTA2-1,3,4-THIADIAZOLIN-5-YLIDENE] ACETAMIDE
• N-(3-Methyl-5-sulfamoyl-3H-[1,3,4]thiadiazol-2-ylidene)-acetamide
• Carbonic Anhydrase IX Inhibitor III, Methazolamide - CAS 554-57-4 - Calbiochem
• Methazolamide USP/EP/BP
• N-(3-Methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide
• MethazolamideQ: What is Methazolamide Q: What is the CAS Number of Methazolamide Q: What is the storage condition of Methazolamide Q: What are the applications of Methazolamide
• Methazolamide (1406005)
• Methazolamid
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