Levoglutamid

L-Glutamine Struktur
56-85-9
CAS-Nr.
56-85-9
Bezeichnung:
Levoglutamid
Englisch Name:
L-Glutamine
Synonyma:
GLUTAMINE;GLN;H-GLN-OH;L-GLN;L-Glutamin;L-Gln-OH;L-GLUTAMIC ACID AMIDE;Concentrated Soy Protein;(S)-2,5-DIAMINO-5-OXOPENTANOIC ACID;L-GUTAMINE
CBNumber:
CB6280105
Summenformel:
C5H10N2O3
Molgewicht:
146.14
MOL-Datei:
56-85-9.mol

Levoglutamid Eigenschaften

Schmelzpunkt:
185 °C (dec.) (lit.)
Siedepunkt:
265.74°C (rough estimate)
alpha 
32.25 º (c=10, 2 N HCl)
Dichte
1.47 g/cm3 (20℃)
FEMA 
3684 | L-GLUTAMINE
Brechungsindex
6.8 ° (C=4, H2O)
Flammpunkt:
185°C
storage temp. 
Store below +30°C.
Löslichkeit
H2O: 25 mg/mL
Aggregatzustand
solution
pka
2.17(at 25℃)
Farbe
White
PH
5.0-6.0 (25℃, 0.1M in H2O)
Geruch (Odor)
at 100.00 %. very mild milky custard cocoa oily
Geruchsart
milky
Optische Aktivität
[α]20/D +33.0±1°, c = 5% in 5 M HCl
Wasserlöslichkeit
Soluble in water, dimethyl sulfoxide and ethanol. Insoluble in methanol, ether, benzene, acetone, ethyl acetate and chloroform.
Decomposition 
185 ºC
maximale Wellenlänge (λmax)
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
JECFA Number
1430
Merck 
14,4471
BRN 
1723797
Stabilität:
Moisture and light sensitive. Incompatible with moisture, strong oxidizing agents.
InChIKey
ZDXPYRJPNDTMRX-VKHMYHEASA-N
LogP
-1.67
CAS Datenbank
56-85-9(CAS DataBase Reference)
NIST chemische Informationen
L-Glutamine(56-85-9)
EPA chemische Informationen
L-Glutamine (56-85-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36-36/37/38
S-Sätze: 26-24/25-36/37/39-27
WGK Germany  2
RTECS-Nr. MA2275100
TSCA  Yes
HS Code  29241900
Giftige Stoffe Daten 56-85-9(Hazardous Substances Data)
Toxizität LD50 orally in Rabbit: 7500 mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Levoglutamid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.

Beschreibung

Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .

Chemische Eigenschaften

L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.

Occurrence

Occurrences in nature
Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources
Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.
Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.

Verwenden

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

Definition

ChEBI: An optically active form of glutamine having L-configuration.

synthetische

By isolation from sugar beet juice.

Biologische Funktion

Glutamine plays a role in a variety of biochemical functions, including :
Protein synthesis, as any other of the 20 proteinogenic amino acids
Regulation of acid-base balance in the kidney by producing ammonium
Cellular energy, as a source, next to glucose
Nitrogen donation for many anabolic processes, including the synthesis of purines
Carbon donation , as a source , refilling the citric acid cycle
Nontoxic transporter of ammonia in the blood circulation.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.

Sicherheitsprofil

Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.

läuterung methode

Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.]

Levoglutamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Levoglutamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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56-85-9(Levoglutamid)Verwandte Suche:


  • 2,5-Diamino-5-oxpentanoicacid
  • L(+)-GLUTAMINE
  • L-GLUTAMINE
  • L(+)-GLUTAMIC ACID-5-AMIDE
  • L-GLUTAMIC ACID 5-AMIDE
  • L-ALPHA-AMINOGLUTAMIC ACID
  • L-2-AMINOGLUTARAMIC ACID
  • 2-aminoglutaramic acid
  • 2-AMINOGLUTARIC ACID-3-MONOAMIDE
  • Miglu-P
  • Pentanoic acid, 2,5-diamino-5-oxo-, (S)-
  • Stimulina
  • H-L-GLN-OH
  • SAB CHLORAM. CONTACT BLISTER DOUBLE-WRAP
  • L-Glutamine Hybri-Max
  • L-Glutamine Vetec(TM) reagent grade, >=99%
  • CHLOROFORM BP
  • GLUTAMINE, L-
  • FEMA 3684
  • (S)-(+)-GLUTAMINE
  • (S)-2,5-Diamino-5-oxopentanoic
  • (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide
  • (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide, L-Glutamine
  • L-Glutamine Powder
  • Glycine, Pyrogen-Free
  • H-Gln-OH ,≥99%
  • L-Glutamine (H-Gln-OH)
  • L-Glutamine,(S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide
  • L-Glutamine, extra pure
  • L-GLUTAMINE, USP
  • L-GlutaMine base
  • L-GLUTAMINERESEARCH GRADE
  • MultiPharM (TM) L-GlutaMine, USP
  • L-GLUTAMINE (3,4-13C2)
  • L-GLUTAMINE (2,3,3,4,4-D5, 15N2)
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  • alpha-glutamine
  • L-GLUTAMINE BIOTECHNOLOGY PERFORMANC
  • L-Glutamine≥ 99% (anhydrous assay)
  • L-Glutamine USP from non-animal source99.0-101.0% (Titration: anhydrous basis)
  • L-Glutamine, 99-100%
  • α-Aminoglutamic acid
  • L-Glutamine, FCC Grade L-2-Aminoglutaramic acid, FCC Grade
  • L-Glutaminee
  • L-GLUTAMINE 200 MM SOLUTION HYBRI-MAX
  • L-GLUTAMINE 98.5+% FCC
  • L-GLUTAMINE, REAGENTPLUS TM, >= 99%
  • L-GLUTAMINE BIOTECHNOLOGY PERFORMANCE &
  • L-GLUTAMINE GAMMA-IRRADIATED CELL*CULTUR E TESTED
  • GLUTAMINE (L) 200 MM
  • L-GLUTAMINE 200 MM STERILE FILTERED*CELL CULTURE TE
  • L-GlutamineForBiochemistry99+%
  • L-GlutamineForBiochemistry
  • L-Glutamine,99%
  • l-glutamine solution
  • L-GLUTAMINE,FCC
  • (2S)-2-amino-4-carbamoyl-butanoic acid
  • L-Glutamine (9CI)
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