Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria
E. coli,
S. aureus,
K. pneumoniae,
A. baumannii,
P. aeruginosa,
E. faecium,
E. faecalis, and
E. cloacae (MICs = 1-4 μg/ml) and the fungus
P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
Chemische Eigenschaften
Beige granules
Verwenden
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.
Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
Indications
Zinc pyrithione is the active ingredient in several shampoos used to control
dandruff and seborrheic dermatitis and is also effective in the therapy of tinea
versicolor. It remains unclear whether the beneficial effects are caused by an
antiproliferative or antimicrobial effect or both. It is substantive to the hair,
allowing continued therapeutic effect after washing.
Allgemeine Beschreibung
Fine beige granules.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.
Brandgefahr
Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible.
Kontakt-Allergie
Zinc pyrithione is widely used in antidandruff
shampoos and is a classic allergen. Concomitant reactions
are expected to both zinc and sodium pyrithione.
Sicherheitsprofil
Poison by ingestion,
skin contact, intraperitoneal, and
intravenous routes. Moderately toxic by
subcutaneous route. An experimental
teratogen. Experimental reproductive
effects. An eye irritant. When heated to
decomposition it emits very toxic fumes of
NOx, SOx, and ZnO. Used as an anti-
dandruff agent in shampoos. See also ZINC
COMPOUNDS and SULFIDES.
Synthese
1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring. To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes. After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water. The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of zinc pyrithione. The zinc pyrithione thus obtained was 212 g with a yield of 99.5 %.
Bis(1-hydroxy-2(1H)-pyridinthiona-to-O,S)zink Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
