5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid

Imipramine hydrochloride Struktur
113-52-0
CAS-Nr.
113-52-0
Bezeichnung:
5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid
Englisch Name:
Imipramine hydrochloride
Synonyma:
g22355;imidol;ia-pram;imavate;iprogen;tofranil;deprinol;dynazina;efuranol;fujisawa
CBNumber:
CB6698241
Summenformel:
C19H25ClN2
Molgewicht:
316.87
MOL-Datei:
113-52-0.mol

5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid Eigenschaften

Schmelzpunkt:
168-1700C
Flammpunkt:
9℃
storage temp. 
2-8°C
Löslichkeit
H2O: 50 mg/mL
Aggregatzustand
crystalline
Farbe
white
PH
4.2~5.2(100g/l,25℃)
Wasserlöslichkeit
Soluble in water
maximale Wellenlänge (λmax)
260nm(lit.)
Merck 
14,4920
CAS Datenbank
113-52-0(CAS DataBase Reference)
EPA chemische Informationen
5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,T,F
R-Sätze: 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11
S-Sätze: 7-16-24-33-45-36-26-36/37
RIDADR  UN 1230 3/PG 2
WGK Germany  3
RTECS-Nr. HO1925000
TSCA  Yes
HS Code  2933995800
Toxizität LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/25:Giftig beim Einatmen und Verschlucken.
R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S7:Behälter dicht geschlossen halten.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S24:Berührung mit der Haut vermeiden.
S33:Maßnahmen gegen elektrostatische Aufladungen treffen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

White Solid

Verwenden

Imipramine hydrochloride is used as a serotonin uptake inhibitor. It mainly used in the treatment of major depression and enuresis (inability to control urination). It has also been evaluated for use in panic disorder.

Allgemeine Beschreibung

Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D2 postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H1block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).

Clinical Use

The demethylated metabolite is less anticholinergic, lesssedative, and more stimulatory and is a SNERI.Consequently, a patient treated with imipramine has twocompounds that contribute to activity. Overall, the effect isnonselective 5-HT versus NE reuptake.

Sicherheitsprofil

Human poison by ingestion. An experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. An experimental teratogen. Human systemic effects by ingestion: sleep, somnolence, convulsions, muscle contraction or spasticity, coma, blood pressure decrease, dyspnea (difficulty in breathing), paresthesia (abnormal sensations), and kidney changes. Experimental reproductive effects. Mutation data reported. Used in the treatment of depression. When heated to decomposition it emits very toxic fumes of NO, and HCl. See also DIAZEPAM.

5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 305)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683
mcbio_sales@163.com China 2255 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58

113-52-0(5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid)Verwandte Suche:


  • Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
  • Imipramine Hydrochloride (200 mg)
  • Methanol(test Imipramine HCl, 1.0 mg/mL as free base)
  • 10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine
  • 5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride
  • tofranil
  • tofranile
  • LABOTEST-BB LT00452014
  • IMIPRAMINE HCL
  • IMIPRAMINE HYDROCHLORIDE
  • Imipramine hydrochloride solution
  • 10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
  • 10,11-DIHYDRO-N,N-DIMETHYL-DIBENZ[B,F]AZEPINE-5-PROPANAMINE HYDROCHLORIDE
  • 10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz[b,f]azepine hydrochloride
  • Imipramin hydrochloride
  • 5H-dibenz[b,f]azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-,monohydrochloride
  • antideprinhydrochloride
  • chimoreptin
  • chrytemin
  • cocapimipramine25
  • deprinol
  • dynazina
  • efuranol
  • f)azepine,10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz(hydrochlor
  • f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochl
  • f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-5h-dibenz(monohydrochloride
  • f)azepine-5-propanamine,10,11-dihydro-n,n-dimethyl-5h-dibenz(monohydroch
  • f]azepine-5-propanamine,10,11-dihydro-n,n-dimethyl-5h-dibenz[monohydrochlo
  • feinalmin
  • fujisawa
  • g22355
  • ia-pram
  • imavate
  • imidol
  • imilanyle
  • imipraminemonohydrochloride
  • iprogen
  • janimine
  • melipraminehydrochloride
  • n-(3-dimethylaminopropyl)iminodibenzylhydrochloride
  • n-(gamma-dimethylaminopropyl)iminodibenzylhydrochloride
  • n-(gamma-dimetilaminopropil)-iminodibenzilecloridrato
  • N-(γ-dimethylaminopropyl)iminodibenzylhydrochloride
  • nsc114900
  • persamine
  • pertofram
  • presamine
  • pryleugan
  • sk-praminehydrochloride
  • teperine
  • IMIPRAMINE HYDROCHLORIDE SIGMAULTRA
  • IMIPRAMINE HYDROCHLORIDE METHANOL*SOLUTI ON
  • CAFFEINE EPC(CRM STANDARD)
  • Imipramine-2,4,6,8-D4HCI
  • 5H-Dibenzb,fazepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride
  • IMIPRAMINEHYDROCHLORIDE,USP
  • 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride, 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
  • Imipramine-2,4,6,8-D4CI
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