Esomeprazole

Esomeprazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Esomeprazole, formulated as a magnesium salt, reached the market as a treatment for acid-related diseases such as gastro-esophageal reflux (GERD) disease including peptic ulcer disease and reflux esophagitis. Esomeprazole (formerly perprazole) is the active (S)- enantiomer of omeprazole (1988) and the first proton pump inhibitor developed as an optical isomer. It can be obtained by several routes such as asymmetric oxidation of the pro-chiral pyridylmethyl benzimidazole sulfide, separation from the racemic sulfoxide by chiral chromatography or separation of a diastereomeric mixture obtained from the racemic compound and a chiral acid, followed by hydrolysis. Biochemical studies have shown that esomeprazole irreversibly inhibits the gastric H⁺/K⁺-adenosine triphosphatase (ATPase), an enzyme system involved at the secretory surface of the stomach’s parietal cells responsible for the secretion of gastric acid. Compared with racemic omeprazole in healthy subjects, esomeprazole has higher bioavailability, is absorbed more rapidly and exhibits a more uniform and predictable dose-response with higher plasma levels, leading to less inter-individual variability between slow and rapid metabolizers. In extensive clinical trials in patients suffering from GERD symptoms, esomeprazole provided superior acid control and significantly reduced the healing time compared to omeprazole.

Verwenden

(-)-Omeprazole can be used to treat migraine.

Verwenden

Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers).  It works by decreasing the amount of acid your stomach makes. It  relieves symptoms such as heartburn, difficulty swallowing, and  persistent cough.

Definition

ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium alt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.

Esomeprazole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Esomeprazole Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Xinyi Dajiang Chemical Co.,Ltd.	+8617314178111	243096958@qq.com	China	5	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hebei Dangtong Import and export Co LTD	+8615632927689	admin@hbdangtong.com	China	991	58
Wuhan Quanjinci New Material Co.,Ltd.	+8615271838296	kyra@quanjinci.com	China	1532	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

119141-88-7()Verwandte Suche:

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• EsoMeprazole EC Pellets 22%
• EsoMaprozole
• 1H-BenziMidazole,6-Methoxy-2-[(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl]-
• EsoMeprazole EC Pellets 8.5%
• 6-Methoxy-2-{(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl}-1H-benziMidazole
• Esomeprazole(Na、Mg)
• (5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfoniumolate
• (S)-Esomeprazole
• Esomeprazole(Mg)
• 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1H-benzimidazole
• 6-Methoxy-2-[(R)-(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-benzoimidazole
• Esomeprazole
• (RelCpd F)
• (S)-5-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfinyl)-1H-benzo[d]iMidazole
• 119141-58-6
• esomeprazole:5-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1h-benzIMIDAZOLE
• -6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)
• Aisi'aomeilazuona Esomeprazole Sodium
• Omeprazole S-Isomer
• Esomeprazol EP Impurity F
• Esomeprzole
• Esomeprazole USP/EP/BP
• Esomeprazole Monomer
• (-)-Omeprazole
• Esomeprazole D3 K salt
• EsomeprazoleQ: What is Esomeprazole Q: What is the CAS Number of Esomeprazole
• 5-Methoxy-2-(4-Methoxy-3,5-diMethyl-pyridin-2-ylMethanesulfinyl)-1H-benzoiMidazole
• 5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole
• Esomeprazol
• (R)-5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole
• (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
• ESOMEPRAZOLE 8.5%, 15.0%, 17%, 22%, 22.5%, 27.10% EC PELLETS
• 119141-88-7
• 119141-58-6
• 217097-09-7
• API
• 119141-88-7