Isopropylacetat Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.
CHEMISCHE GEFAHREN
Reagiert sehr heftig mit oxidierenden Materialien. Greift viele Kunststoffe an.
ARBEITSPLATZGRENZWERTE
TLV: 100 ppm (als TWA); 200 ppm (als STEL); (ACGIH 2005).
MAK: 100 ppm, 420 mg/m?Spitzenbegrenzung: überschreitungsfaktor I(2); Schwangerschaft: Gruppe C; (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation der Dämpfe und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Der Dampf reizt die Augen und die Atemwege. Verschlucken kann zur Aufnahme in der Lunge führen; Gefahr der Aspirationspneumonie. Exposition weit oberhalb der Arbeitsplatzgrenzwerte kann Bewusstseinstrübung verursachen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Die Flüssigkeit entfettet die Haut.
LECKAGE
Ausgelaufene Flüssigkeit möglichst in abdichtbaren Glasbehältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe.
R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Isopropyl acetate is a colourless liquid with an intense, fruity odor. On dilution, it has a sweet apple-like flavor. Miscible with most organic solvents such as alcohols, ketones and ethers. 2.9% (w/w) soluble in water at 20°C. Synthesized by direct acetylation of isopropyl alcohol in the presence of various catalysts: concentrated H2S04, diethyl sulfate, chlorosulfonic acid, and boron trifluoride.
Physikalische Eigenschaften
Clear, colorless liquid with an aromatic odor. Experimentally determined detection and
recognition odor threshold concentrations were 2.1 mg/m
3 (500 ppb
v) and 3.8 mg/m
3 (910 ppb
v),
respectively (Hellman and Small, 1974).
Occurrence
Reported found in pineapple, pear, cocoa, apple, banana, black currants, grapes, melons, strawberry, cheddar
cheese, beer, white wine, red wine, cocoa, honey, soybean, yellow passion fruit, beans, plum brandy and nectarines
Verwenden
Isopropyl acetate is used as a solvent for nitrocellulose, plastics, oils, and fats, and as a flavoring agent. Isopropyl Acetate is a widely used chemical solvent in organic and industrial syntheses. Also used in the dissolution of gallstones. Environmental contaminants; Food contaminants.
Application
Isopropyl acetate is a solvent in chemical industry, especially for cellulose, plastics, waxes, resins, gums, paints, oil and fats. and also as flavoring agent. It is an active component of perfumes and printing inks. It is also employed as an extractant for the preparation of antibiotics, vitamins and hormones.
Definition
ChEBI: Isopropyl acetate is a branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.
synthetische
Isopropyl acetate is prepared from propylene and anhydrous acetic acid in the presence of a catalyst . It may also be produced by direct acetylation of isopropyl alcohol in the presence of various catalysts; concentrated H2SO4, diethyl sulfate, chlorosulfonic acid and boron trifluoride.
Allgemeine Beschreibung
Isopropyl acetate appears as a clear colorless liquid. Flash point 40°F. Vapors are heavier than air. Contact with the material may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used as a solvent.
Air & Water Reaktionen
Highly flammable. Less dense than water and slightly soluble in water.
Reaktivität anzeigen
Isopropyl acetate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Isopropyl acetate can react vigorously with nitrates, strong oxidizers, strong alkalis and strong acids. Isopropyl acetate may also attack some forms of rubber, plastics and coatings. .
Health Hazard
Isopropyl acetate is an irritant to the eyes,nose, and throat. Liquid irritates eyes but causes no serious injury; may cause dermatitis; no serious effects if swallowed. The acute toxicity in laboratory animals was low. Exposure to highconcentrations in air or ingestion can produce narcotic effects. A 4-hour exposure to aconcentration of 32,000 ppm in air was fatalto rats (ACGIH 1986). The oral LD50 valuein rats is in the range 6000 mg/kg.
Brandgefahr
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Environmental Fate
Chemical/Physical. Hydrolyzes in water forming isopropyl alcohol and acetic acid (Morrison
and Boyd, 1971). The estimated hydrolysis half-life at 25 °C and pH 7 is 8.4 yr (Mabey and Mill,
1978).
At an influent concentration of 1,000 mg/L, treatment with GAC resulted in an effluent
concentration of 319 mg/L. The adsorbability of the carbon used was 137 mg/g carbon (Guisti et
al., 1974).
läuterung methode
Wash the acetate with 50% aqueous K2CO3 (to remove acid), then with saturated aqueous CaCl2 (to remove any alcohol). Dry it with CaCl2 and fractionally distil it. [Beilstein 2 IV 141.]
Isopropylacetat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
16,17-Epoxy-16-methyl pregn-9(11)-en-3-ol-20-one
19-CARBOXYANDROST-4-ENE-3,17-DIONE
1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
5 A-CHLORO-6 B,19-EPOXY-3 B -HYDROXY-5 A-ANDROSTAN-17-ONE
6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
4-(Aminosulfonyl)phenylboronic acid
9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate
4-(2'-Oxobenzimidazolin-1'-yl)piperidin
1-METHANESULFONYL-PIPERAZINE
6alpha,9-difluoro-11beta,21-dihydroxypregna-1,4,16-triene-3,20-dione 21-acetate
5-CHLORO-6 B,19-EPOXY-5A -ANDROTANE-3,17-DIONE
Oxendolone
Estron
3-Acetyloxy-16,17-epoxy-16-methylpregn-5-en-20-one
5-Azaindole
3,17,21-Trihydroxypregna-3,5,9(11)-trien-20-one 3,17,21-triacetate
Aclatonium napadisilate
9-Fluor-11β,21-dihydroxypregna-1,4,16-trien-3,20-dion-21-acetat
3,17-Dihydroxy-16-methylpregna-5,15-diene-20-one 3-acetate
Vitamin-A-alkohol
ironic ion stabiliger CT^{1～7^}
Benzylacetat
19-Hydroxyandrost-4-en-3,17-dion
Ethylpiperazin-1-carboxylat
Pyridoxinhydrochlorid
4-tert-Butyl-3-hydroxy-2,6-xylylacetonitril
16,17-Epoxy-3-hydroxy-16-methyl-pregn-9(11)-ene-20-one-3-acetate
Triamcinolone 21-acetate
17-Ethinylandrost-5-ene-3,17-diol
16,17-Epoxy-3,17-dihydroxyestra-1,3,5(10)-triene-3,17-diacetate
Tirofiban
Dopaminhydrochlorid
Diphosphorsäuretetrakis-(phenylmethyl)ester
Hydrocortison
17-Hydroxy-6-methylenpregn-4-en-3,20-dion-17-acetat
9β,11β-Epoxy-17,21-dihydroxypregn-4-en-3,20-dion
3β-Hydroxy-5α-pregna-9(11),16-dien-20-on-3-acetat
