Suxamethoniumchlorid

Succinylcholine Chloride Struktur
71-27-2
CAS-Nr.
71-27-2
Bezeichnung:
Suxamethoniumchlorid
Englisch Name:
Succinylcholine Chloride
Synonyma:
SUXAMETHONIUM CHLORIDE;Anectine;skolin;DITILIN;midarine;pantolax;LYSTHENON;SUCCICURAN;lysthenone;myoplegine
CBNumber:
CB7206483
Summenformel:
C14H30Cl2N2O4
Molgewicht:
361.3
MOL-Datei:
71-27-2.mol

Suxamethoniumchlorid Eigenschaften

Schmelzpunkt:
164 °C
storage temp. 
Refrigerator
Löslichkeit
Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
Merck 
8875
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents.
CAS Datenbank
71-27-2(CAS DataBase Reference)
EPA chemische Informationen
Succinylcholine chloride (71-27-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 7/8
RIDADR  3249
RTECS-Nr. GA2360000
HazardClass  6.1(b)
PackingGroup  III
Toxizität LD50 i.v. in mice: 0.45 mg/kg (Anttila, Ertama)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H311 Giftig bei Hautkontakt. Akute Toxizität dermal Kategorie 3 Achtung P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H332 Gesundheitsschädlich bei Einatmen. Akute Toxizität inhalativ Kategorie 4 Warnung P261, P271, P304+P340, P312
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P312 Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P321 Besondere Behandlung
P332+P313 Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P362 Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Suxamethoniumchlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S7/8:Behälter trocken und dicht geschlossen halten.

Beschreibung

Succinylcholine chloride is a potent relaxant of voluntary striated muscle but has little direct effect on smooth muscle. It has no anesthetic or pain-obliterating properties; therefore, immobilized animals remain completely conscious although unable to move. The duration of effect is quite brief because succinylcholine is rapidly destroyed by non-specific cholinesterases in the blood plasma and liver. Immobilization lasts five to 12 minutes in man and horses and somewhat longer in other species,with ruminants generally requiring longest recovery periods (Stowe et al. 1958).
Since the discovery of its curariform properties in 1949, succinylcholine has been widely used for immobilization of animals and in human surgical procedures. Several workers have used succinylcholine on bears (Black 1958, Knudsen 1959, Craighead et al. 1960, Troyer et al. 1961,Hornocker 1962, Mundy 1963,Pearson et al. 1968, Jonkel and Cowan 1971 and Mundy and Flook 1973).
Succinylcholine chloride is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Chemische Eigenschaften

Succinylcholine chloride is a white, odorless, slightly bitter powder and very soluble in water. The drug is unstable in alkaline solutions but relatively stable in acid solutions, depending upon the concentration of the solution and the storage temperature. Solutions of succinylcholine chloride should be stored under refrigeration to preserve potency.

Verwenden

A neuromuscular blocking agent. Muscle relaxant (skeletal).

Definition

ChEBI: A chloride salt in which the negative charge of the chloride ions is balanced by succinylcholine dications.

Weltgesundheitsorganisation (WHO)

Suxamethonium chloride is a short-acting muscle relaxant. It is used in surgery. Suxamethonium chloride is listed in the WHO Model List of Essential Drugs.

Biologische Funktion

Succinylcholine chloride (Anectine) is the only depolarizing- type blocker that is in widespread clinical use. It produces neuromuscular block by overstimulation, so that the end plate is unable to respond to further stimulation. Structurally, succinylcholine is equivalent to two ACh molecules joined back to back. The resulting 10- carbon atom spacing between the two quaternary ammonium heads is important for activation of the two binding sites on the AChR. Because the succinylcholine molecule is “thin,” binding to the two sites does not sterically occlude the open channel, and cations are allowed to flow and depolarize the end plate.
Neuromuscular block with succinylcholine occurs by two sequential events. An initial depolarization of the end plate produces muscle action potentials and fasciculation. Maintained depolarization past the threshold for firing produces Na channel inactivation, so that muscle action potentials cannot be generated. This is called phase I, or depolarization block. In the continued presence of succinylcholine, the membrane becomes repolarized, Na channel inactivation is reversed, and muscle membrane excitability is restored. Nonetheless, the neuromuscular block persists because of desensitization of the AChR. This is known as phase II, or desensitization block.
Although the mechanism for phase II block is not completely understood, a series of allosteric transitions in the AChR is suspected. One model to describe this has the AChR in equilibrium among four conformations: resting, active, inactive, and desensitized. Agonists stabilize the active and desensitized states, whereas antagonists tend to stabilize the resting and possibly the desensitized state.

Allgemeine Beschreibung

Succinylcholine chloride,choline chloride succinate (2:1) (Anectine, Sucostrin),is a white, odorless, crystalline substance that is freely solublein water to give solutions with a pH of about 4. It isstable in acidic solutions but unstable in alkali. Aqueous solutionsshould be refrigerated to ensure stability.
Succinylcholine chloride is characterized by a very shortduration of action and a quick recovery because of its rapidhydrolysis after injection. It brings about the typical muscularparalysis caused by blocking nervous transmission at themyoneural junction. Large doses may cause temporary respiratorydepression, as with similar agents. Its action, in contrastwith that of (1)-tubocurarine, is not antagonized byneostigmine, physostigmine, or edrophonium chloride.These anticholinesterase drugs actually prolong the action ofsuccinylcholine chloride, which suggests that the drug isprobably hydrolyzed by cholinesterases. The brief durationof action of this curare-like agent is said to render an antidoteunnecessary if the proper supportive measures are available.Succinylcholine chloride has a disadvantage, however, inthat the usual antidotes cannot terminate its action promptly.

Air & Water Reaktionen

Water soluble.

Brandgefahr

Flash point data for SUCCINYLCHOLINE CHLORIDE are not available. SUCCINYLCHOLINE CHLORIDE is probably combustible.

Clinical Use

Succinylcholine Chloride is used as a muscle relaxant for the same indications asother curare agents. It may be used for either short or longperiods of relaxation, depending on whether one or severalinjections are given. In addition, it is suitable for continuousintravenous drip administration.
Succinylcholine chloride should not be used withthiopental sodium because of the high alkalinity of the latter.If used together, they should be administered immediatelyafter mixing; however, separate injection is preferable.

Suxamethoniumchlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Suxamethoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 157)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9354 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004
1015@dideu.com China 2263 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10326 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
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HONG KONG IPURE BIOLOGY CO.,LIMITED
86 18062405514 18062405514
ada@ipurechemical.com CHINA 3465 58

71-27-2(Suxamethoniumchlorid)Verwandte Suche:


  • succinyl-asta
  • succinylbischolinechloride
  • succinylbischolinedichloride
  • succinyl-cholindichloride
  • succinylcholinedichloride
  • succinyldicholinechloride
  • succinylforte
  • sucostrinchloride
  • sukcinylcholinchlorid
  • suxamethoniumdichloride
  • CHOLINE SUCCINATE DICHLORIDE
  • DIACETYLCHOLINE DICHLORIDE
  • DITILIN
  • BIS[(2-DIMETHYLAMINO)ETHYL]SUCCINATE BIS(METHOCHLORIDE)
  • SCOLINE CHLORIDE
  • SUCCICURAN
  • SUCCINYLCHOLINE CHLORIDE
  • 2,2-succinyldioxybis(ethyltrimethylammonium) dichloride
  • SuccinylcholineChloride,>98%
  • SuccinylcholineChloride/SuxamethoniumChlorideC14H30Cl2N2O4
  • LYSTHENON
  • bis(succnyldichlorocholine)
  • 2,2'-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium Chloride
  • (2-hydroxyethyl)trimethylammoniumchloridesuccinate
  • succinylcholine chloride (anhydrous)
  • Succinylcholine Chloride (500 mg)
  • 2,2'-(succinylbis(oxy))bis(N,N,N-triMethylethanaMiniuM) chloride
  • EthanaMiniuM,2,2'-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-triMethyl-, chloride (1:2)
  • 2,2’-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[n,n,n-trimethyl-ethanaminiudi
  • 2-dimethylaminoethylsuccinatedimethochloride
  • anectinechloride
  • bis(succinyldichlorocholine)
  • chlorsuccinylcholin
  • chloruredesuccinilcoline
  • choline,chloride,succinate(2:1)
  • clorurodisuccinilcolina
  • diacetylcholinechloride
  • Ethanaminium,2,2’-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis(N,N,N-trimethyl)-,dichloride
  • lysthenone
  • midarine
  • myoplegine
  • pantolax
  • quelicinchloride
  • skolin
  • succinicacid,bis(beta-dimethylaminoethyl)ester,dimethochloride
  • succinicacid,diesterwithcholinechloride
  • succinoylcholinechloride
  • Suxamethonium chloride CRS
  • SUCCINYLCHOLINE CHLORIDE USP/EP/BP
  • SUXAMETHONIUM CHLORIDE
  • Anectine
  • 71-27-2
  • C14H30Cl2N2O4
  • C14H30N2O42Cl
  • C14H30N2O4
  • Quaternary Ammonium Compounds
  • Ammonium Chlorides (Quaternary)
  • Other APIs
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