Betamethason Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in
configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases
and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical
trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active.
Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest
that it is best used for short-term therapy.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Betamethasone is a glucocorticoid used as an anti-inflammatory agent.
Allgemeine Beschreibung
Betamethasone, 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,is available as a variety of ester derivatives.
Betamethasone valerate, USP (17-valerate)
Betamethasone acetate, USP (21-acetate)
Betamethasone sodium phosphate, USP (21-sodiumphosphate)
Betamethasone dipropionate, USP (17-propionate,21-propionate).
Nebenwirkungen
Toxic side effects, such as increased appetite, weight gain, and
facial mooning, occur with prolonged use.
Sicherheitsprofil
Low toxicity by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes of F-.
läuterung methode
Betamethasone crystallises from ethyl acetate, and has max at 238nm (log 4.18) in MeOH. The 21-acetate [287-24-6] crystallises from Me2CO/Et2O (charcoal) m 196-201o (205-208o) and has [] D 20 +140o (CHCl3). [Taub et al. J Am Chem Soc 82 4012 1960, Olivetto et al. J Am Chem Soc 80 6688 1958, Beilstein 8 IV 3501.]
Betamethason Upstream-Materialien And Downstream Produkte
Upstream-Materialien
9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-21-acetat
Hydrogenchlorid
6 beta-hydroxybetamethasone 17-propionate
9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17,21-di(propionat)
6-hydroxybetamethasone
9-Fluor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17-propionat
Downstream Produkte
