Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)-
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- CAS-Nr.
- 24729-96-2
- Bezeichnung:
- Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)-
- Englisch Name:
- Clindamycin phosphate
- Synonyma:
- Clindets;Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2-pyrrolidinyl]carbonyl]amino]-2-O-phosphono-1-thio-L-threo-α-D-galacto-octopyranoside;Methyl 7-chloro-6,7,8-trideoxy-6-trans-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate);Methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside2-(dihydrogenphosphate);methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-l-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside 2-(dihydrogen phosphate);Methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S)-1-methyl-4β-propyl-2α-pyrrolidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside 2-dihydrogen phosphate;u28508;U-28508E;dalacinp;Dalacin T
- CBNumber:
- CB8175076
- Summenformel:
- C18H34ClN2O8PS
- Molgewicht:
- 504.96
- MOL-Datei:
- 24729-96-2.mol
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Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)- Eigenschaften
- Schmelzpunkt:
- 114 °C
- Siedepunkt:
- 159°C
- Dichte
- 1.41±0.1 g/cm3(Predicted)
- Brechungsindex
- 122 ° (C=1, H2O)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- DMSO: soluble224mg/mL at 25°C
- Aggregatzustand
- solid
- pka
- pKa 0.964±0.06
(H2O t=21) (Uncertain);6.06 ±0.06 (I=0.008)(H2O t=21) (Uncertain)
- Farbe
- White
- Wasserlöslichkeit
- Freely soluble in water
- Merck
- 14,2356
- Stabilität:
- Stable, but store cool. Incompatible with strong oxidizing agents, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, B group sodium vitamins.
- InChIKey
- UFUVLHLTWXBHGZ-YFBDLMQENA-N
- SMILES
- [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1)O)([C@@H](Cl)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O |&1:0,2,4,5,7,13,18,23,26,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,Xi |
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| R-Sätze: |
22-36/37/38 |
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| S-Sätze: |
36-26 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
GF2625000 |
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| HS Code |
29419000 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H362 |
Kann Säuglinge über die Muttermilch schädigen. |
Reproductive toxicity, effects on or via lactation |
Additional category |
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P201, P260, P263, P264, P270,P308+P313 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P263 |
Kontakt während der Schwangerschaft /und der Stillzeit vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)- Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
solid or colorless solution with characteristic alcohol odor.
synthetische
Preparation of Clindamycin Phosphate: a solution of 808 mg of the phosphorylated ester in 6 ml of pyridine and 16 ml of acetic acid is stirred at ambient temperature while s5 mg of zinc is rapidly added. The mixture is filtered after one hour and evapo rated to a residue which is heated with stirring at 50°C. for 2 hours with a solvent mixture of 2 ml of acetic acid, and 4 ml of 0.5N sulfuric acid. The mixture is cooled and filtered followed by evaporation of the filtrate in vacuo to a residue, which is chromatographed on a suitable ion-exchange resin, in the acid form, and eluted with 2% ammonium hydroxide. The desired product is obtained as ammonium salt by evaporation of the product fractions. (dec. 212°C)
Allgemeine Beschreibung
Clindamycin phosphate (Cleocin Phosphate) is the 2-phosphateester of clindamycin. It exists as a zwitterionic structurethat is very soluble in water. It is intended for parenteral(intravenous or intramuscular) administration for the treatmentof serious infections and instances when oral administrationis not feasible. Solutions of clindamycin phosphateare stable at room temperature for 16 days and for up to 32days when refrigerated.
Kontakt-Allergie
This lincosanide antibiotic is used in topical form for acne,
or systemically has been responsible for exanthematous
rashes and acute generalized exanthematous pustulosis.
Pharmakologie
Clindamycin phosphate is available in 1% concentration in a hydroalcoholic
vehicle (30 or 60 mL) as a gel or lotion. Although the drug has
not been detected in the blood after topical use, its detection in the urine
suggests that 4% to 5% of topically applied clindamycin is absorbed.
Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)- Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 577)Lieferanten
24729-96-2(Methyl-7-chlor-6,7,8-tridesoxy-6-(((1-methyl-4-propyl-2-pyrrolidi-nyl)carbonyl)amino)-1-thio-L-threo-alpha-D-galacto-octopyrano-sid-2-(dihydrogenphosphat),(2S-trans)-)Verwandte Suche:
- (2s-trans)-
- 2-(dihydrogenphosphate
- U-28508E
- Clindamycin phosphate BP98,USP25,EP97
- Clindaymcin Palmitate hydrochloride USP23
- L-threo-.alpha.-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(2S,4R)-1-methyl-4-propyl-2-pyrrolidinylcarbonylamino-1-thio-, 2-(dihydrogen phosphate)
- CLINDAMYCINPHOSPHATE,CRYSTAL,USP
- CLINDAMYCIN PHOSPHATE/ 7-(S)-CHLORO-7-DEOXY-LINCOMYCIN-2-ORGANIC PHOSPHATE
- Cleocin T
- Dalacin T
- L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, 2-(dihydrogen phosphate), trans- α- (8CI)
- L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate), (2S-trans)-
- L-threo-α-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, 2-(dihydrogen phosphate)
- NSC 618653
- CLINDAMYCINISOPROPYLIDENE
- methyl (2S-trans)-7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside, 2-(dihydrogen phosphate)
- Clindamycine phosphate
- Clindamycin HCl/Phosphate (DMF)
- Clindamycin 2-phosphate,Clindamycin 2-dihydrogen phosphate
- Clindamycin Phosphate (250 mg)
- Clindamycin Phosphate (125 mg)
- 7-Epi ClindaMycin Hydrochloride
- Methyl 7-Chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-Methyl-4-propyl-2-pyrrolidinyl]
carbonyl]aMino]-1-thio-D-erythro-α-D-galactooctopyranoside Hydrochloride
- ClindaMycin phosphate API
- 7(S)-Chloro-7-deoxylincoMycin 2-phosphate, Cleocin phosphate, ClindaMycin phosphate, NSC 618653, U 28508
- Clindamycin Phosphate (300 mg)
- Clindamycin phosphate USP
- Clindamycin Phosphate (U-28508E)
- methyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-2-(dihydrogen phosphate)- L-threo-α-D-galacto-octopyranoside
- Clindamycin phosphate for system suitability
- 7(s)-chloro-7-deoxylincomycin2-phosphate
- cleocinphosphate
- dalacinp
- l-threo-alpha-d-galacto-octapyranoside,methyl7-chloro-6,7,8-trideoxy-6-(((1-m
- u28508
- ANTIBIOTIC U-28508E
- CLINDAMYCIN PHOSPHATE
- CLINDAMYCIN 2-DIHYDROGEN PHOSPHATE
- CLINDAMYCIN 2-PHOSPHATE
- 7(S)-CHLORO-7-DEOXYLINCOMYCIN
- clindamycin phosphate sterile
- Clindamycin Impurity 9(Clindamycin Phosphate)
- [(2R,4R,5R)-6-[(2S)-2-chloro-1-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]-oxomethyl]amino]propyl]-4,5-dihydroxy-2-(methylthio)-3-oxanyl] dihydrogen phosphate
- (2R,3R,4S,5R,6R)-6-((1S,2S)
- Clindamycin phosphate in stock Factory
- Clindamycin Phosphate Impurity
- Clindamycin hydrochloride crude ester
- Clindamycin Phosphate Usp30/Ep6
- indamycin phosphate
- Clindamycin phosphate for system suitability CRS
- Clindamycin phosphate CRS
- Clindamycin Phosphate >
- Clindamycin 2-Phosphate for System Suitability
- CLINDAMYCIN PHOSPHAT USP/EP/BP
- Clindmycin phosphate hydrochloride USP/EP/BP
- Clindamycin phosphate USP/EP/BP
- (2R,3R,4S,5R,6R)-6-((1S,2S)-2-Chloro-1-((2S,4R)-1-methyl-4-propylpyrrolidine-2-carboxamido)propyl)-4,5-dihydroxy-2-(methylthio)tetrahydro-2H-pyran-3-yl dihydrogen phosphate
- [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate
