(+)-Weinsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Tartaric acid occurs as colorless monoclinic crystals, or a white or almost white crystalline powder. It is odorless, with an extremely tart taste. L-(+)-Tartaric Acid is a naturally occurring chemical compound found in berries, grapes and various wines. It provides antioxidant properties and contributes to the sour taste within these products.
Definition
ChEBI: L-tartaric acid is a tetraric acid that is butanedioic acid substituted by hydroxy groups at positions 2 and 3. It is a conjugate acid of a L-tartrate(1-). It is an enantiomer of a D-tartaric acid.
Vorbereitung Methode
Tartaric acid occurs naturally in many fruits as the free acid or in
combination with calcium, magnesium, and potassium.
Commercially, L-(＋)-tartaric acid is manufactured from potassium
tartrate (cream of tartar), a by-product of wine making.
Potassium tartrate is treated with hydrochloric acid, followed by the
addition of a calcium salt to produce insoluble calcium tartrate.
This precipitate is then removed by filtration and reacted with 70%
sulfuric acid to yield tartaric acid and calcium sulfate.
Allgemeine Beschreibung
Tartaric Acid belongs to the group of carboxylic acids, and is abundantly found in grapes and wine. It is widely used in drugs, food, and beverage industry.
Pharmazeutische Anwendungen
Tartaric acid is used in beverages, confectionery, food products, and
pharmaceutical formulations as an acidulant. It may also be used as
a sequestering agent and as an antioxidant synergist. In pharmaceutical
formulations, it is widely used in combination with
bicarbonates, as the acid component of effervescent granules,
powders, and tablets.
Tartaric acid is also used to form molecular compounds (salts
and cocrystals) with active pharmaceutical ingredients to improve
physicochemical properties such as dissolution rate and solubility.
Sicherheitsprofil
Moderately toxic by intravenous route. Mildly toxic by ingestion. Reaction with silver produces the unstable silver tartrate. When heated to decomposition it emits acrid smoke and irritating fumes.
Sicherheit(Safety)
Tartaric acid is widely used in food products and oral, topical, and
parenteral pharmaceutical formulations. It is generally regarded as
a nontoxic and nonirritant material; however, strong tartaric acid
solutions are mildly irritant and if ingested undiluted may cause
gastroenteritis.
An acceptable daily intake for L-(＋)-tartaric acid has not been set
by the WHO, although an acceptable daily intake of up to 30 mg/kg
body-weight for monosodium L-(＋)-tartrate has been established.
LD50 (mouse, IV): 0.49 g/kg
Lager
The bulk material is stable and should be stored in a well-closed
container in a cool, dry place.
Inkompatibilitäten
Tartaric acid is incompatible with silver and reacts with metal
carbonates and bicarbonates (a property exploited in effervescent
preparations).
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (IM and IV
injections; oral solutions, syrups and tablets; sublingual tablets;
topical films; rectal and vaginal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
(+)-Weinsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(1R,2R)-(-)-1,2-Diaminocyclohexane
(1S,2S)-(-)-1,2-Diphenyl-1,2-ethanediamine
(+)-2,2-Dimethyl-4,5-((diphenylphosphino)dimethyl)dioxolan
1H-PYRROLO[2,3-B]PYRIDINE, 2-METHYL-
(-)-(1S,4R)-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID
(R)-Chinuclidin-3-ol
Diammoniumtartrat
trans-2,5-Dimethylpiperazine
(-)-Weinsure
2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol
(+)-(3R,4R)-BIS(DIPHENYLPHOSPHINO)-1-BENZYLPYRROLIDINE
Levosulpiride
(+)-Taddol
(1S,2S)-(+)-1,2-Diaminocyclohexane
L-α-Methylbenzylamin
5-Azaindole
METARAMINOL
(1R,2S,4R)-Born-2-ylamin
Levamisolhydrochlorid
Tris(2-methylphenyl)phosphin
1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)
(1R,2R)-(+)-1,2-Diaminocyclohexane L-tartrate
(S)-1-Boc-3-(hyroxymethyl)piperidine
(R)-3-Quinuclidinol hydrochloride
