Gomisin A
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- CAS-Nr.
- 58546-54-6
- Englisch Name:
- Gomisin A
- Synonyma:
- D01752;TJN-101;GOMISIN A;Besigomsin;BESIGOMISIN;wuweizichunb;SCHIZANDROL B;SCHISANDROL B;wuweizialcoholb;Grifola frondsa
- CBNumber:
- CB8374224
- Summenformel:
- C23H28O7
- Molgewicht:
- 416.47
- MOL-Datei:
- 58546-54-6.mol
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Gomisin A Eigenschaften
- Schmelzpunkt:
- 88.5°C
- Siedepunkt:
- 454.79°C (rough estimate)
- Dichte
- 1.1772 (rough estimate)
- Brechungsindex
- 1.5300 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- Aggregatzustand
- powder to crystal
- pka
- 14.58±0.40(Predicted)
- Farbe
- White to Light yellow
- LogP
- 4.770 (est)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
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| HS Code |
29329990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
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Gomisin A Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Schisandrol B is a lignan originally isolated from
S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including
Cyp3a11,
Ugt1a1,
Oatp2, and
Mrp3 in mouse liver and
CYP3A4,
UGT1A1, and
OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not
Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .
Chemische Eigenschaften
White powder
Verwenden
Schizandrol B exhibits potent protective effects of on ET-1-induced dysfunctional human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). Anti-cholestasis effect.
Gomisin A Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Gomisin A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 219)Lieferanten
58546-54-6()Verwandte Suche:
- 2,3,13-tetramethoxy-l-stereoisomer
- benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy
- wuweizialcoholb
- wuweizichunb
- BESIGOMISIN
- GOMISIN A
- SCHISANDROL B
- SCHIZANDROL B
- Besigomsin
- Besigomsin (jan/inn)
- D01752
- Gomisin A/Schisandrin
- (6S,7S)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6β,7β-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6α-ol
- TJN-101
- Schizandrol B, froM Schisandra chinensis
- Schisandrol B (Gomisin-A
- Schizandrol B, 98%, from Schisandra chinensis (Turcz.) Baill.
- Gomisin A Standard
- Grifola frondosa (Dicks.) Gray
- Grifola frondsa
- Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-6-ol, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6S,7S,13aR)-
- Schizandrol B，Gomisin A
- (6S,7S)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol
- (6S,7S,13aR)-5,6,7,8-Tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol
- (6S,7S,13aR)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol
- Schisandrin ethyl alcohol
- (6S,7S,13aR)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-ol
- 58546-54-6
- 58546-54-8
- C23H28O7
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Miscellaneous Natural Products
