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6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin

S-(4-NITROBENZYL)-6-THIOINOSINE Struktur
38048-32-7
CAS-Nr.
38048-32-7
Bezeichnung:
6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin
Englisch Name:
S-(4-NITROBENZYL)-6-THIOINOSINE
Synonyma:
NBMPR;NBTI;NSC 296962;nitrobenzylthioinosine;4-nitrobenzylthioinosine;6-(p-nitrobenzylthio)inosine;S6-(4-nitrylbenzyl)thioinosine;S-(4-NITROBENZYL)-6-THIOINOSINE;S-(P-NITROBENZYL)-6-THIOINOSINE;4-Nitrobenzyl-6-mercaptoinosine
CBNumber:
CB8713230
Summenformel:
C17H17N5O6S
Molgewicht:
419.41
MOL-Datei:
38048-32-7.mol
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6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin Eigenschaften

Schmelzpunkt:
187-190 °C(lit.)
Siedepunkt:
770.2±70.0 °C(Predicted)
Dichte
1.3904 (rough estimate)
Brechungsindex
1.6460 (estimate)
storage temp. 
2-8°C
Löslichkeit
0.1 M HCl: slightly soluble
Aggregatzustand
solid
pka
13.08±0.70(Predicted)
Farbe
white
CAS Datenbank
38048-32-7(CAS DataBase Reference)

Sicherheit

S-Sätze: 24/25
WGK Germany  3
RTECS-Nr. UO9025000
HS Code  29349990

6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

Off-White Solid

Verwenden

S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.

Allgemeine Beschreibung

S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.

Biologische Aktivität

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

[3,4-dibenzoyloxy-5-(6-chloropurin-9-yl)oxolan-2-yl]methyl benzoate 6-Chlor-9-ribofuranosyl-9H-purin 2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9--D-RIBOFURANOSIDE 1-O-ACETYL-2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSE 4-nitrobenzyl mercaptan α-Chlor-4-nitrotoluol 6-Chlorpurin

Downstream Produkte

6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 97)Lieferanten
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38048-32-7(6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin)Verwandte Suche:

6-((4-Nitrobenzyl)thio)-9-β-D-ribofuranosylpurin
  • S-(P-NITROBENZYL)-6-THIOINOSINE
  • S-(4-NITROBENZYL)-6-THIOINOSINE
  • NBTI
  • 4-nitrobenzylthioinosine
  • 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin
  • 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine
  • 6-(p-nitrobenzylthio)inosine
  • 6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE
  • nitrobenzylthioinosine
  • S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA
  • S-(P-NITROBENZYL)-6-THIOINOSINE 98+%
  • S-(4-Nitrobenzyl)-6-thioinosine (NBTI, NBMPR)
  • 6-[(4-nitrobenzyl)thio]-9-β-d-ribofuranosylpurine
  • 6-[(4-Nitrobenzyl)-mercapto]-inosine
  • 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
  • NSC 296962
  • S-(p-Nitrobenzyl)-6-mercapto-9--D-ribofuranosylpurine
  • NBMPR, NBTI, 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine
  • 4-Nitrobenzyl-6-mercaptoinosine
  • 6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosyl-9H-purine
  • 6-[[(4-Nitrophenyl)methyl]thio]-9-(β-D-ribofuranosyl)-9H-purine
  • S-(4-Nitrobenzyl)-6-thioinosine,99%
  • (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((4-nitrobenzyl)thio)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
  • Inosine, 6-S-[(4-nitrophenyl)methyl]-6-thio-
  • NBMPR
  • S6-(4-nitrylbenzyl)thioinosine
  • 38048-32-7
  • C17H17N5O6S
  • Bases & Related Reagents
  • Heterocycles
  • Inhibitors
  • Nucleotides
  • Sulfur & Selenium Compounds
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