Corosolic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Corosolic acid is a triterpenoid that has been found in
L. speciosa leaves and has diverse biological activities, including anticancer, anti-inflammatory, antidiabetic, antihypertensive, antihyperlipidemic, and antioxidant properties. It is cytotoxic to HepG2, A549, SNU-C4, HeLa S3, and K562 cells (EC
50s = 4.8, 5, 0.4, 1, and 4.3 μg/ml, respectively). Corosolic acid inhibits ear edema in mice induced by phorbol 12-myristate 13-acetate (TPA; ) with an ID
50 value of 0.09 mg/ear. It reduces blood glucose levels in an insulin tolerance test in a KKAy mouse model of type 2 diabetes when administered at doses of 2 and 10 mg/kg. Corosolic acid (0.072% in the diet) reduces systolic blood pressure and serum levels of free fatty acids, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and 8-hydroxy-2’-deoxyguanosine (8-OHdG), and the myeloperoxidase markers 3-nitrotyrosine and 3-chlorotyrosine in an SHR/NDmcr-cp (
cp/cp) rat model of metabolic syndrome.
Verwenden
(2α,3β)-2,3-Dihydroxy-urs-12-en-28-oic Acid influences inflammatory gene expression regarding inflammatory bowel disease. In addition, its extracted from the plants Gentiana farreri and shows anti-tum
or activity
Definition
ChEBI: A natural product found particularly in Rhododendron species and Eriobotrya japonica.
Corosolic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
