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Irinotecan

CAS No. 97682-44-5
Chemical Name: Irinotecan
Synonyms: CPT-11;DQ-2805;SN-38-11;CAMPTOSAR;IRINOTECAN;Irinotecane;IRINOTECAN HCL;Irinotecan base;IRINOTECAN HCL(P);Irinotecan(TECANS)
CBNumber: CB1124156
Molecular Formula: C33H39ClN4O6
Formula Weight: 623.14
MOL File: 97682-44-5.mol
Irinotecan Property
Melting point : 222-223°
storage temp. : 2-8°C
CAS DataBase Reference: 97682-44-5(CAS DataBase Reference)
Safety
Hazard Codes : Xn
Risk Statements : 22
RTECS : DW1061000
Hazardous Substances Data: 97682-44-5(Hazardous Substances Data)

Irinotecan Chemical Properties,Usage,Production

Uses
Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively
Definition
ChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydro y-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcino a of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Irinotecan Preparation Products And Raw materials
Raw materials
Nitrogen (+)-Camptothecin 7-Ethyl camptothecin 7-Ethyl-10-hydroxycamptothecin
Preparation Products
Irinotecan Suppliers      Global( 215)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd. +86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Wuhan Kai Lun new material Chemical Co Ltd 025-87787262;15071332665
025-87787262 wshun@51chemall.com China 497 58
Shanghai Boyle Chemical Co., Ltd. 86-15221043597
86-21-57758967 sales@boylechem.com China 2848 55
SiChuang NanBu Honesty Technology Co., Ltd. 0838-5675166
0838-5675535 nbcxkj@126.com China 717 55
Sichuan Ruibo Technology Co., Ltd +86-817-5586080
+86-817-5527378 sales@scrbkj.com China 42 69
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15949 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6035 61
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807
010-87653215;0757-86311057;021-55236763 sales@hwrkchemical.com China 15554 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44197 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18
0086-571-85864795 sales@capotchem.com China 18279 66
 
97682-44-5(Irinotecan)Related Search:
Paclitaxel Docetaxel (+)-Camptothecin IRINOTECAN-D10 HYDROCHLORIDE IRINOTECAN HCL TRIHYDRATE,IRINOTECAN HYDROCHLORIDE TRIHYDRATE,IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE,Irinotecan Hydrochlorid 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride IRINOTECAN 4-METHYL ANALOGUE Irinotecan Carboxylate Sodium Salt Irinotecan HCL for Injection Mefenpyr-diethyl Diethyl phthalate Diethyl ether Diethyl malonate Diethyl carbonate Irinotecan CARBOXYLIC ACID IRINOTECAN HCL,IRINOTECAN HYDROCHLORIDE Tetrahydro
Irinotecan (free Base) Irinotecan(TECANS) 1,4'-Bipiperidine-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester Camptothecin series APIs Natural Anti-cancer Medical Materials and It's Derivatives API's DQ-2805 (4S)-4,11-Diethyl-4-hydroxy-9-[[(4-piperidinopiperidino)carbonyl]oxy]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione SN-38-11 97682-44-8 (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate API chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Camptosar, Campto Anti-cancer&immunity (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl-[1,4'-bipiperidine]-1'-carboxylic acid Anti cancer Inhibitors Irinotecan Labeled d10 (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2- (s)-[1,4'-bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER TOPOTECIN HYDROCHLORIDE 97682-44-5 [1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID CPT-11 IRINOTECAN IRINOTECAN HCL CAMPTOSAR CAMPTOTHECIN 11 HYDROCHLORIDE CAMPTOTHECIN 11 HYDROCHLORIDE,TOPOTECIN Irinotecan(Cpt-11) (1,4'-Bipiperidine)-1'-carboxylicacid(S)-4,11-di] Irinotecane C33H38N4O6 [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester IRINOTECAN HCL(P) [1,4'-Bipiperidine]-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester (9CI) [1,4'-Bipiperidine]-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester, (S)- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline, [1,4'-bipiperidine]-1'-carboxylic acid deriv. Irinotecan base
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