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GW5074

GW5074 structure

CAS No.: 220904-83-6

Chemical Name:: GW5074

Synonyms: W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;RAF1 KINASE INHIBITOR I;Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem;3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one

CBNumber:: CB0130215

Molecular Formula:: C15H8Br2INO2

Molecular Weight:: 520.94

MDL Number:: MFCD09971042

MOL File:: 220904-83-6.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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GW5074 Properties

Boiling point	561.4±50.0 °C(Predicted)
Density	2.248±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble
form	solid
pka	5.86±0.25(Predicted)
color	yellow to orange-brown
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	LMXYVLFTZRPNRV-XCVCLJGOSA-N
CAS DataBase Reference	220904-83-6
FDA UNII	P0LE4QW0S6

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2933790090

GW5074 price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G6416	GW5074 powder	220904-83-6	5mg	$166	2024-03-01	Buy
Sigma-Aldrich	553008	Raf1 Kinase Inhibitor I	220904-83-6	1mg	$187	2024-03-01	Buy
Cayman Chemical	10010368	GW 5074 ≥98% (mixture of cis and trans)	220904-83-6	1mg	$37	2024-03-01	Buy
Cayman Chemical	10010368	GW 5074 ≥98% (mixture of cis and trans)	220904-83-6	5mg	$116	2024-03-01	Buy
Sigma-Aldrich	G6416	GW5074 powder	220904-83-6	25mg	$649	2024-03-01	Buy

Product number	Packaging	Price	Buy
G6416	5mg	$166	Buy
553008	1mg	$187	Buy
10010368	1mg	$37	Buy
10010368	5mg	$116	Buy
G6416	25mg	$649	Buy

GW5074 Chemical Properties,Uses,Production

Description

GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

Uses

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biological Activity

Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.

Biochem/physiol Actions

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

storage

Desiccate at -20°C

References

1) Chang et al. (2005), Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK pathways; Cell Signal., 217 299 2) Huang et al. (2006), Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway; J. Pharmacol. Sci., 102 305 3) Lackey et al. (2000), The discovery of potent cRaf1 kinase inhibitors; Bioorg. Med. Chem. Lett., 10 223 4) Chen et al. (2004), Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells; J. Immunol., 173 5219

GW5074 Preparation Products And Raw materials

Raw materials

Preparation Products

GW5074 Suppliers

Global( 147)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

View Lastest Price from GW5074 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-24	(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co
	2019-12-23	(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
220904-83-6
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
220904-83-6
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

GW5074 Spectrum

GW5074(220904-83-6)¹HNMR

220904-83-6(GW5074)Related Search:

GW284543 GW788388 GW9662 GW441756 Everolimus

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GW 284543 hydrochloride - UNC 10225170 hydrochloride 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine GW9508 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- GW5074

6-IODO-2,3-DIHYDRO-1H-INDOLE 2H-INDOL-2-ONE, 1,3-DIHYDRO-5-IODO- 2-ETHYL-4-IODO-PHENYLAMINE

1of4

RAF1 KINASE INHIBITOR I (3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE 5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE 3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE 3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE GW5074 2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one GW5074, >=98% (Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one GW-5074;GW 5074 Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem GW 5074;GW-5074;GW5074 CS-399 W5074 GW5074 USP/EP/BP 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-2,3-dihydro-1H-indol-2-one 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one (3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6 20904-83-6 C15H8Br2INO2 BioChemical Cell Signaling and Neuroscience Cell Biology Kinase/Phosphatase Biology Raf Serine/Threonine Kinase Inhibitors MAPK Inhibitors