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Sofalcone

CAS No.
64506-49-6
Chemical Name:
Sofalcone
Synonyms
su88;solon;Sofacone;SOFALCONE;SOFALCONE JP;isoprenylchalcone;Mr. Method ketone;Sofalcone USP/EP/BP;SOFALCONE MICROPOWDER;l)-1-oxo-2-propenyl)phenoxy)-
CBNumber:
CB0143037
Molecular Formula:
C27H30O6
Molecular Weight:
450.52
MDL Number:
MFCD00868207
MOL File:
64506-49-6.mol
Last updated:2023-06-08 09:02:10

Sofalcone Properties

Melting point 143-144°
Boiling point 478.6°C (rough estimate)
Density 1.1362 (rough estimate)
refractive index 1.4870 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka 2.98±0.10(Predicted)
color Light Yellow
CAS DataBase Reference 64506-49-6(CAS DataBase Reference)
FDA UNII 2B668TJX8E

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Toxicity LD50 in mice, rats: >10 g/kg orally (Tarumoto)
NFPA 704
0
2 0

Sofalcone price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11882 Sofalcone ≥98% 64506-49-6 100mg $49 2024-03-01 Buy
Cayman Chemical 11882 Sofalcone ≥98% 64506-49-6 250mg $115 2024-03-01 Buy
Cayman Chemical 11882 Sofalcone ≥98% 64506-49-6 500mg $216 2024-03-01 Buy
TRC S675500 Sofalcone 64506-49-6 2g $225 2021-12-16 Buy
Biosynth Carbosynth FS27851 Sofalcone 64506-49-6 500mg $90 2021-12-16 Buy
Product number Packaging Price Buy
11882 100mg $49 Buy
11882 250mg $115 Buy
11882 500mg $216 Buy
S675500 2g $225 Buy
FS27851 500mg $90 Buy

Sofalcone Chemical Properties,Uses,Production

Pharmacological action

Sofalcone is an effective component extracted and synthesized from traditional Chinese medicine Sophora tonkinensis. It is the product of isoprene derivatives. It can increase gastric blood flow, expand gastric mucosal blood vessels, increase oxygen consumption in gastric tissue, promote gastric mucosal repair, increase gastric wall composition and increase prostaglandin content in gastric tissue. Its mechanism is to inhibit prostaglandin 5hydroxyl prostaglandin dehydrogenase (PG). This product has a good effect on the ulcer of the digestive tract by enhancing the defense factor. It is mainly used for the treatment of gastric ulcer and gastritis.
Structural formula for sofalcone
Figure 1 Structural formula for sofalcone

Pharmacokinetics

This product is absorbed quickly after oral administration, and the concentration is up to the peak in about one hour. The half life of plasma is about 1h, and it will almost disappear in the blood after 2h. The main metabolites in the body are the reductive products of the alpha and beta unsaturated bonds of the chalcone skeleton, and the oxidation products of the isoprene side chain. It is excreted from urine by 6% to 8% in the form of isoprene chain oxidation products within 48h.

Description

Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a strengthening of the mucosal barrier through an increase in blood flow and stimulation of the synthesis of sulfated mucopolysaccharides.

Originator

Japan (Japan)

Uses

Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]

Uses

Sofalcone is a substituted chalcone with anti-ulcer activity.

Definition

ChEBI: Sofalcone is a member of the class of chalcones that is benzene in which the hydrogens at positions 1,2 and 5 are replaced by carboxymethoxy, (1E)-1-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-oxoprop-1-en-3-yl, and (3-methylbut-2-en-1-yl)oxy groups, respectively. It is a gastrointestinal drug currently used for treatment of gastritis and gastric ulcers in Japan and South Korea. It has a role as an anti-ulcer drug, a gastrointestinal drug, a plant metabolite and an antibacterial agent. It is an aromatic ether, a monocarboxylic acid and a member of chalcones.

Sofalcone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 180)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290 1056@dideu.com China 3959 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
Qiuxian Baitai New Material Co., LTD
+8618330912755 sale2@hbyalin.com China 1677 58
Handan Tongyi New Material Technology Co., Ltd
+8617330042575 ty003@handantongyi.com China 364 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58

View Lastest Price from Sofalcone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sofalcone pictures 2023-02-24 Sofalcone
64506-49-6
US $20.00 / kg 1kg 99% 5000 Ton Hebei Duling International Trade Co. LTD
Sofalcone pictures 2022-10-29 Sofalcone
64506-49-6
US $100.00-50.00 / kg 1kg 99 Monthly supply of 1 ton Hebei Shengyuan Jinlong Import and Export Co. LTD
Sofalcone pictures 2021-12-10 Sofalcone
64506-49-6
US $10.00 / KG 1KG 99 300kg/month Handan Tongyi New Material Technology Co., Ltd
  • Sofalcone pictures
  • Sofalcone
    64506-49-6
  • US $20.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
  • Sofalcone pictures
  • Sofalcone
    64506-49-6
  • US $100.00-50.00 / kg
  • 99
  • Hebei Shengyuan Jinlong Import and Export Co. LTD
  • Sofalcone pictures
  • Sofalcone
    64506-49-6
  • US $10.00 / KG
  • 99
  • Handan Tongyi New Material Technology Co., Ltd
{5-[(3-methyl-2-butenyl)oxy]-2-{p-[(3-methyl-2-butenyl)oxy]cinnamoyl}phenoxy}acetic acid SOFALCONE SOFALCONE(2'-ETHOXYCARBONYLMETHOXY-4'-(3-METHYL-2-BUTENYL-OXY)ACETOPHENONE) SOFALCONE JP SOFALCONE MICROPOWDER [4,4'-Bis(3-methyl-2-butenyloxy)chalcon-2'-yloxy]acetic acid [5-[(3-Methyl-2-butenyl)oxy]-2-[3-[4-[(3-methyl-2-butenyl)oxy]phenyl]-1-oxo-2-propenyl]phenoxy]acetic acid 2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-Methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]acetic Acid 2’-carboxymethoxy-4,4’-bis(3-methyl-2-butenyloxy)chalcone aceticacid,(5((3-methyl-2-butenyl)oxy)-2-(3-(4-((3-methyl-2-butenyl)oxy)pheny isoprenylchalcone l)-1-oxo-2-propenyl)phenoxy)- solon su88 Mr. Method ketone 2-[5-(3-methylbut-2-enoxy)-2-[(E)-3-[4-(3-methylbut-2-enoxy)phenyl]-1-oxoprop-2-enyl]phenoxy]acetic acid Acetic acid, 2-[5-[(3-methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]- Sofalcone USP/EP/BP 2-(5-((3-Methylbut-2-en-1-yl)oxy)-2-(3-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)acryloyl)phenoxy)acetic acid Sofacone 64506-49-6 4506-49-6 506-49-6 C27H30O6