ChemicalBook >> CAS DataBase List >>Canrenone
Canrenone
- CAS No.
- 976-71-6
- Chemical Name:
- Canrenone
- Synonyms
- CANRENONE-D4;sc9376;11614r.p;RP-11614;CANRENONE;phanurane;ALDADIENE;kanlitong;NSC 261713;Canrenone CRS
- CBNumber:
- CB0147626
- Molecular Formula:
- C22H28O3
- Molecular Weight:
- 340.46
- MDL Number:
- MFCD00071735
- MOL File:
- 976-71-6.mol
- MSDS File:
- SDS
Last updated:2024-03-22 17:12:53
| Melting point | 158-1600C |
|---|---|
| alpha | D +24.5° (chloroform) |
| Boiling point | 416.25°C (rough estimate) |
| Density | 1.1236 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +17 to +24°, c = 1 in chloroform-d |
| Water Solubility | 272.4ug/L(25 ºC) |
| InChI | InChI=1/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/s3 |
| InChIKey | UJVLDDZCTMKXJK-MUWITHSMNA-N |
| SMILES | [C@@]12(CCC(=O)O1)CC[C@@]1([H])[C@]3([H])C=CC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]21C |&1:0,8,10,20,22,26,r| |
| LogP | 2.54 at 25℃ |
| CAS DataBase Reference | 976-71-6 |
| FDA UNII | 78O20X9J0U |
| ATC code | C03DA03 |
| NIST Chemistry Reference | Canrenone(976-71-6) |
Canrenone price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1497 | Canrenone ≥97% (HPLC) | 976-71-6 | 50mg | $80.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR2887 | Spironolactone Related Compound A pharmaceutical secondary standard, certified reference material | 976-71-6 | 150MG | $344 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1619017 | Spironolactone Related Compound A United States Pharmacopeia (USP) Reference Standard | 976-71-6 | 100mg | $1490 | 2024-03-01 | Buy |
| Alfa Aesar | J60238 | Canrenone, 98% | 976-71-6 | 1g | $59.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60238 | Canrenone, 98% | 976-71-6 | 5g | $187.65 | 2024-03-01 | Buy |
Canrenone Chemical Properties,Uses,Production
Chemical Properties
Pale yellow to pale Green Solid
Originator
Spiroctan,Boehringer Mannheim,Switz.,1968
Uses
Inhibits aldosterone biosynthesis and blocks ouabain effects
Uses
antiinflammatory, glucocorticoid
Uses
Aldosterone antagonist. Diuretic
Definition
ChEBI: Canrenone is a steroid lactone.
Manufacturing Process
The lactone is prepared as follows: A solution of 5 parts of 17α-carboxyethyl- 17β-hydroxyandrost-4-en-3-one lactone and 5 parts of chloranil in 400 parts of xylene containing a trace of p-toluenesulfonic acid is heated at the boiling point of the solvent under reflux overnight. The solution is then cooled and filtered through approximately 200 parts of silica gel. The gel is successively washed with 5%, 10%, and 15% ethyl acetate-benzene solutions, and the washings comprising 15% ethyl acetate are thereupon purified by chromatography on a further quantity of silica gel, using benzene and ethyl acetate as developing solvents. From the 15% ethyl acetate eluate there is obtained pure 17α-carboxyethyl-17β-hydroxyandrost-4,6-dien-3-one lactone, melting at 148° to 151°C. The product solidifies above this melting point and melts again at 165°C.
brand name
Luvion.
Therapeutic Function
Aldosterone antagonist, Diuretic
World Health Organization (WHO)
Canrenone, which has aldosterone antagonist activity, is a major metabolite of spironolactone and the major metabolite of potassium canrenoate. See WHO comments for potassium canrenoate and spironolactone.
Flammability and Explosibility
Non flammable
Biological Activity
Mineralocorticoid receptor antagonist. Active metabolite of spironolactone ((7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone ).
Biochem/physiol Actions
Canrenone is a mineralocorticoid (aldosterone) inhibitor.
Canrenone Preparation Products And Raw materials
Global( 254)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 | Jany1001@kangcang.com.cn | China | 338 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from Canrenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Canrenone
976-71-6
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-22 | Canrenone
976-71-6
|
US $9.00-60.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-22 | Canrenone
976-71-6
|
US $30.00 / box | 1box | 98% | 2000box | hebei hongtan Biotechnology Co., Ltd |
976-71-6(Canrenone)Related Search:
TRIOXSALEN
11-a-Hydroxy canrenone methyl ester
Delta 9,11-canrenone
(7a,17a)-17-Hydroxy-3-oxo-pregna-4,9(11)-diene-7,21-dicarboxylicacid g-lactone methyl ester
6-B-HYDROXY EPLERENONE
1of4
phanurane
pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph
sc9376
spirolactonesc14266
CANRENOIC ACID GAMMA LACTONE
CANRENONE
4,6-ANDROSTADIEN[(17(B-1')-SPIRO-5')]-PERHYDROFURAN-2,3-DIONE
4,6-ANDROSTEN-17-ALPHA-YL-PROPIONIOACID-R-LACTONE
PREGNA-4,6-DIENE-17-BETA-0L-3-ONE-21-CARBOXYLIC ACID-GAMMA LACTONE
11614r.p
17-(2-Carboxyethyl)17-hydroxy-3-oxoandrosta-4,6-dienelactone
17-(2-Carboxyethyl)17-hydroxyandrosta-4,6-dien-3-onelactone
17-hydroxy-3-oxo-,gamma-lactone,(17-alpha)-pregna-6-diene-21-carboxylicacid
17-Hydroxy-3-oxo-17-pregna-4,6-diene-21-carboxylicacid-lactone
ALDADIENE
17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
CANRENONE[SPIRONOLACTONE INTERMEDIATE]
Canrenone98.5%Min
17a-(2-Carboxyethyl-17b-hydroxyandrosta-4,6-dien-3-one Lactone
(7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid g-Lactone
((7 )-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone)
(7a)-17-Hydroxy-3-oxo-pregna-4,6-diene-21-carboxylic Acid -Lactone
17a-2-Carboxyethyl-17-hydroxyandrosta-4,6-dien-3-one Lactone
Journal of risperidone
Canrenone, >=97%
(17R)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone
(17R)-3-Oxo-17-hydroxypregna-4,6-diene-21-carboxylic acid γ-lactone
(17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylicacidγ-lactone
Spironolactone Related Compound A (100 mg) (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (AS)
Eplerenone IMpurity - Canrenone
(8R,9S,10R,13S,14S,17R)-10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
Spironolactone Related CoMpound A
Pregna-4,6-diene-21-carboxylicacid, 17-hydroxy-3-oxo-, g-lactone, (17a)-
Canrenone
17-hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid gamma-lactone
NSC 261713
7-Carboxy-9(11)&Delta
kanlitong
Spironolactone Impurity 6（Spironolactone EP Impurity F）
Spironolactone EP Impurity F
Eplerenone Impurity 28
10,13-Dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione
Canrenone Solution, 100ppm
Eplerenone Canrenone Impurity
Canrenone CRS
6,7-Dehydro-7α-desthioacetylspironolactone
RP-11614
Spironolactone EP Impurity F-d4 (Canrenone-d4)
Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, (17α)-
Spironolactone EP Impurity F (Canrenone)
7-Carboxy-9(11)Δ-canrenone
Spiranolactone Impurity F
Canrenone D7Q: What is
Canrenone D7 Q: What is the CAS Number of
Canrenone D7 Q: What is the storage condition of
Canrenone D7 Q: What are the applications of
Canrenone D7
CanrenoneQ: What is
Canrenone Q: What is the CAS Number of
Canrenone Q: What is the storage condition of
Canrenone Q: What are the applications of
Canrenone
Spironolactone Related Compound A (Canrenone (3-Oxo-17-alpha-pregna-4,6-diene-21, 17-carbolactone)) (1619017)
CANRENONE-D4
Candy, ketone
6,7-Dehydro-7α-desthioacetylspironolactone
Spironolactone USP Related Compound A