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APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT

APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT Structure
APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT structure
CAS No.
Chemical Name:
APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT
Synonyms
RHAPO E4;HUMAN APOE4;APO-E4, HUMAN;APOLIPOPROTEIN E4;HUMAN APOLIPOPROTEIN E4;APOLIPOPROTEIN E, HUMAN;APOLIPOPROTEIN E4 HUMAN;APOLIPOPROTEIN E-IV, HUMAN;APO-E4, HUMAN BACULOVIRUS SYSTEM R-DNA;APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT
CBNumber:
CB0165794
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00285515
MOL File:
Mol file
Last updated:2023-04-23 13:52:06
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APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT Properties

storage temp. -20°C
form buffered aqueous solution

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A3234 Apolipoprotein E4 human recombinant, expressed in E. coli, ≥90% (SDS-PAGE and HPLC), lyophilized powder 100μG $448 2023-06-20 Buy
Product number Packaging Price Buy
A3234 100μG $448 Buy

APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT Chemical Properties,Uses,Production

General Description

Apolipoprotein E (ApoE) is present in the brain and is mainly produced by astrocytes. It is a 299 amino acid glycoprotein of 34kDa. It is present in all classes of lipoproteins except LDL (low-density lipoprotein). APOE?gene has three alleles, such as APOE?ε3, APOE?ε4?and APOE?ε2. It is located on human chromosome 19q13.

Biochem/physiol Actions

Apolipoprotein E4 is a member of the apolipoprotein E family of plasma lipoproteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. ApoE4 regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, regulate the activity of enzymes involved in lipid metabolism and bind amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer′s disease. ApoE exists in three major isoforms: E2, E3, and E4, which differ from one another by a single amino-acid substitution. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT Preparation Products And Raw materials

Raw materials

Preparation Products

APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT Suppliers

Global( 41)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Huzhen Industrial Co., LTD 021-60345367 13916550749 sales@shzbio.com China 9965 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Sigma-Aldrich 80
Shanghai Huzhen Industrial Co., LTD 58
RHAPO E4 APOLIPOPROTEIN E4 APOLIPOPROTEIN E4 HUMAN APOLIPOPROTEIN E, HUMAN APOLIPOPROTEIN E, ISOFORM E4, HUMAN, RECOMBINANT APOLIPOPROTEIN E-IV, HUMAN APOLIPOPROTEIN E-IV, HUMAN BACULOVIRUS SYSTEM R-DNA APO-E4, HUMAN APO-E4, HUMAN BACULOVIRUS SYSTEM R-DNA HUMAN APOE4 HUMAN APOLIPOPROTEIN E4