Veratric Acid
- CAS No.
- 93-07-2
- Chemical Name:
- Veratric Acid
- Synonyms
- VERATRIC ACID;NSC 7721;AKOS 220-15;reratric acid;VERATRIC ACID(RG);AKOS BBS-00003717;Veratrumenoic acid;RARECHEM AL BO 0042;Veratric acid (8CI);DiMethoxybenzoic aci
- CBNumber:
- CB0176264
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00002500
- MOL File:
- 93-07-2.mol
- MSDS File:
- SDS
| Melting point | 179-182 °C(lit.) |
|---|---|
| Boiling point | 275.56°C (rough estimate) |
| Density | 1.2481 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 0.5g/l |
| form | Crystalline Powder |
| pka | 4.35±0.10(Predicted) |
| color | Almost white to beige or reddish |
| Water Solubility | slightly soluble |
| Merck | 14,9953 |
| BRN | 518285 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | DAUAQNGYDSHRET-UHFFFAOYSA-N |
| LogP | 1.610 |
| CAS DataBase Reference | 93-07-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1YY04E7RR4 |
| NIST Chemistry Reference | Benzoic acid, 3,4-dimethoxy-(93-07-2) |
| EPA Substance Registry System | Benzoic acid, 3,4-dimethoxy- (93-07-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG8598750 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29189090 | |||||||||
| NFPA 704 |
|
Veratric Acid price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D131806 | 3,4-Dimethoxybenzoic acid ≥99% | 93-07-2 | 100g | $86.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.45140 | 3,4-Dimethoxybenzoic acid Msynth?plus | 93-07-2 | 250G | $179 | 2022-05-15 | Buy |
| Sigma-Aldrich | 8.45140 | 3,4-Dimethoxybenzoic acid Msynth?plus | 93-07-2 | 1KG | $575 | 2022-05-15 | Buy |
| TCI Chemical | D0631 | 3,4-Dimethoxybenzoic Acid >98.0%(GC)(T) | 93-07-2 | 25g | $29 | 2024-03-01 | Buy |
| TCI Chemical | D0631 | 3,4-Dimethoxybenzoic Acid >98.0%(GC)(T) | 93-07-2 | 500g | $197 | 2024-03-01 | Buy |
Veratric Acid Chemical Properties,Uses,Production
Description
Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits and has antioxidant and anti-inflammatory activities. It also acts as a protective agent against hypertension-associated cardiovascular remodeling. Veratric acid reduces upregulated COX-2 expression and levels of PGE2 and IL-6 after UVB irradiation. This compound could be reduced to veratrine aldehyde, and alcohol was performed with enzyme extracts from a wood-degrading basidiomycete, Polystictus (Trametes) versicolor[1].
Chemical Properties
white to slightly yellow powder
Uses
3,4-Dimethoxybenzoic acid is a derivative of Protocatechuic Acid.3,4-Dimethoxybenzoic acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.
Uses
3,4-Dimethoxybenzoic acid plays an important role in producing antibiotics and various dyes. They are used as intermediates for pharmaceuticals (especially for antipyretic analgesic, antirheumatism) and other organic synthesis. It is used as matrix for ionization of peptides, proteins and carbohydrates.
Definition
ChEBI: A member of the class of benzoic acids that is benzoic acid substituted by methoxy groups at positions 2 and 3.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 26, p. 299, 1978 DOI: 10.1248/cpb.26.299
Tetrahedron Letters, 43, p. 4985, 2002 DOI: 10.1016/S0040-4039(02)00929-2
in vitro
Veratric acid (100, 200 μM) suppresses iNOS expression in LPS-stimulated RAW264.7 cells. Veratric acid (200 μM) inhibits LPS-induced activation of the PI3K/Akt pathway, HAT activation, and HDAC3 expression in RAW264.7 cells.
Veratric Acid (10-100 μg/mL) has anti-inflammatory activity, protects HaCaT cells against UVB-mediated phototoxicity, increases S-phase cells, and prevents UVB-mediated apoptosis.
Veratric acid reduces upregulated COX-2 expression and levels of PGE2, and IL-6 after UVB irradiation.
Purification Methods
Crystallise the acid from Et2O, H2O or aqueous acetic acid. It has m 180-181o after sublimation at 80o/1mm. [Beilstein 10 H 393, 10 I 188, 10 II 261, 10 III 1404, 10 IV 1406.]
References
[1] Gross, Georg G. “From lignins to tannins: Forty years of enzyme studies on the biosynthesis of phenolic compounds.” Phytochemistry 69 18 (2008): Pages 3018-3031.
Veratric Acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12457 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1175 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
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- Mar 27，2024
View Lastest Price from Veratric Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | 3,4-Dimethoxybenzoic acid
93-07-2
|
US $0.00 / Kg/Drum | 1KG | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-22 | 3,4-Dimethoxybenzoic acid
93-07-2
|
US $30.00 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-04-18 | Veratric Acid
93-07-2
|
US $50.00 / kg | 1kg | 99.10% | 5000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- 3,4-Dimethoxybenzoic acid
93-07-2
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 3,4-Dimethoxybenzoic acid
93-07-2
- US $30.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- Veratric Acid
93-07-2
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd