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2-Methyl-4-isothiazolin-3-one

2-Methyl-4-isothiazolin-3-one Structure
2-Methyl-4-isothiazolin-3-one structure
CAS No.
2682-20-4
Chemical Name:
2-Methyl-4-isothiazolin-3-one
Synonyms
2-METHYL-4-ISOTHIAZOLIN-3-ONE;2-METHYL-3(2H)-ISOTHIAZOLONE;2-Methylisothiazol-3(2H)-one;2-Methyl-4-isothiazolin-3-on;METHYLISOTHIAZOLONE;Casson preservatives;2-methyl-2H-isothiazol-3-one;2-METHYL-4-ISOTHIAZOLINE-3-ONE;2-Methyl-3-isothiazolone;2-Methyl-2H-isothiazole-3-one
CBNumber:
CB0193926
Molecular Formula:
C4H5NOS
Molecular Weight:
115.15
MDL Number:
MFCD00013254
MOL File:
2682-20-4.mol
MSDS File:
SDS
Last updated:2024-04-22 15:07:34
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2-Methyl-4-isothiazolin-3-one Properties

Melting point 254-256 °C(lit.)
Boiling point bp0.03 93°
Density 1.25 (14% aq.)
vapor pressure <0.1 mm Hg ( 25 °C)
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate
pka -2.03±0.20(Predicted)
color Yellow
Water Solubility 489g/L at 20℃
BRN 606203
InChIKey BEGLCMHJXHIJLR-UHFFFAOYSA-N
LogP -0.486 at 20℃
CAS DataBase Reference 2682-20-4(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances 2-METHYL-4-ISOTHIAZOLIN-3-ONE
EWG's Food Scores 4-7
FDA UNII 229D0E1QFA
NIST Chemistry Reference 3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System 2-Methyl-3(2H)-isothiazolone (2682-20-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H301+H311-H314-H317-H330-H410
Precautionary statements  P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  N,C,T
Risk Statements  50/53-50-43-34-20/21/22-37-23-22
Safety Statements  60-61-36/37/39-26-24-45
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  FE1250000
HazardClass  8
PackingGroup  III
HS Code  29349990

2-Methyl-4-isothiazolin-3-one price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 5g $101 2024-03-01 Buy
Sigma-Aldrich 725765 2-Methyl-4-isothiazolin-3-one 95% 2682-20-4 25g $401 2024-03-01 Buy
Sigma-Aldrich 73569 2-Methyl-4-isothiazolin-3-one analytical standard 2682-20-4 1g $129 2024-03-01 Buy
Cayman Chemical 28136 Methylisothiazolinone 2682-20-4 1mL $28 2024-03-01 Buy
Cayman Chemical 28136 Methylisothiazolinone 2682-20-4 5mL $77 2024-03-01 Buy
Product number Packaging Price Buy
725765 5g $101 Buy
725765 25g $401 Buy
73569 1g $129 Buy
28136 1mL $28 Buy
28136 5mL $77 Buy

2-Methyl-4-isothiazolin-3-one Chemical Properties,Uses,Production

Description

Methylisothiazolinone (also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of  isothiazolinones.
Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, methylisothiazolinone is allergenic. It is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.

Uses

2-Methyl-4-isothiazolin-3-one, or MIT as it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or &ldquo;chemical substance capable of killing living organisms, usually in a selective way.&rdquo;Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.

Safety

Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MIT would not be neurotoxic as used in cosmetics. Although recognizing that MIT was a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MIT at 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MIT may be safely used as a preservative in cosmetics up to that concentration.

References

[1] http://www.safecosmetics.org/get-the-facts/chemicals-of-concern/methylisothiazolinone/
[2] K. Yazar, M. D. Lundov, A. Faurschou, M. Matura, A. Boman, J. D. Johansen, C. Lidén (2015) Methylisothiazolinone in rinse-off products causes allergic contact dermatitis: a repeated open-application study, 173, 115-122
[3] https://www3.epa.gov/pesticides/chem_search/reg_actions/reregistration/fs_G-58_1-Oct-98.pdf

Description

2-Methyl-4-isothiazolin-3-one (MI) is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI). MI is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone. MIC values are 7 to 200-fold lower when MI is used in combination with MCI. MI decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays. MI, alone and as a mixture with MCI, can elicit contact sensitization.

Chemical Properties

2-Methyl-4-isothiazolin-3-one (MIT) is a colorless,clear liquid with amild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. MIT is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%.

Uses

Methylisothiazolinone is a preservative compound widely used in cosmetics. It is a contact allergen and sensitiser. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.

Uses

2-Methyl-4-isothiazolin-3-one (methylisothiazolinone) is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.

Definition

ChEBI: Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM). It has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.

Preparation

2-Methyl-4-isothiazolin-3-one (MIT)is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:    NCSCH=CHC(O)NHCH3?SCH=CHC(O)NCH3+HCN

Hazard

2-Methyl-4-isothiazolin-3-one(MIT)is allergenic and cytotoxic, and this has led to some concern over its use.A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT.

Contact allergens

MI is generally associated with MCI, in Kathon? CG, MCI/MI, and Euxyl? K 100. This preservative is currently used in water-based products such as cosmetics, paints, and glues. Skin contact with concentrated solution can cause severe irritant dermatitis.

Side effects

Early on, dermatitis may occur only on part of the exposed skin. Common patterns include: hand dermatitis，perianal dermatitis, perivulval dermatitis, napkin dermatitis, facial dermatitis, eyelid swelling, and scalp dermatitis. Later, more extensive and severe whole-body contact dermatitis may occur in very sensitive people.

2-Methyl-4-isothiazolin-3-one synthesis

999-72-4
2682-20-4
Synthesis of 2-Methyl-4-isothiazolin-3-one from N,N'-Dimethyl-3,3'-dithiodipropionamide

2-Methyl-4-isothiazolin-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

2-Methyl-4-isothiazolin-3-one Suppliers

Global( 456)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yibangte Import and Export Co. , Ltd. 		+86-0311-85030958 +8615532196582 lisa@yibangte.com China 2987 58
Jinan Qinmu Fine Chemical Co.,Ltd.
+8618660799346 sales@qinmuchem.com China 1009 58
WUXI HONOR SHINE CHEMICAL CO.,LTD
0510-83593312 +8613665125081 sales@honorshinechem.com China 61 58
Suzhou Genemill Biotechnology Co.,Ltd
+86-0512-65917170; +8615862502491 aimeegao@genemill.com China 39 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7786 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 401 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Supplier Advantage
Hebei Yibangte Import and Export Co. , Ltd. 		58
Jinan Qinmu Fine Chemical Co.,Ltd.
58
WUXI HONOR SHINE CHEMICAL CO.,LTD
58
Suzhou Genemill Biotechnology Co.,Ltd
58
Hebei Yanxi Chemical Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

Related articles

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  • Methylisothiazolinone(MIT), along with other isothiazolinones, is a biocide widely used as a preservative in personal care pro....
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View Lastest Price from 2-Methyl-4-isothiazolin-3-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
methyl chloroisothiazolinone and methyl isothiazolinone (CMIT/MIT) pictures 2024-04-22 methyl chloroisothiazolinone and methyl isothiazolinone (CMIT/MIT)
2682-20-4
 US $120.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
Methylisothiazolinone pictures 2024-04-22 Methylisothiazolinone
2682-20-4
 US $28.00 / kg 1kg 99% 20t Hebei Yime New Material Technology Co., Ltd.
PC-950 Isothiazolinone pictures 2024-03-26 PC-950 Isothiazolinone
2682-20-4
 US $0.00 / liter 1liter 9.5~9.9% (w/w) 100tons Suzhou Genemill Biotechnology Co.,Ltd

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