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MG-115

MG-115 structure

CAS No.: 133407-86-0

Chemical Name:: MG-115

Synonyms: MG-115;Z-LLnV;(S)-MG115;Z-LL-NVA-CHO;MG115, Z-LLnV;Z-LEU-LEU-NVA-H;Z-LEU-LEU-NVA-CHO;z-leu-leu-norvalinal;Z-LEU-LEU-NVA-ALDEHYDE;MG-115 (DMSO solution)

CBNumber:: CB0195607

Molecular Formula:: C25H39N3O5

Molecular Weight:: 461.59

MDL Number:: MFCD00274411

MOL File:: 133407-86-0.mol

MSDS File:: SDS

Last updated:2023-09-04 15:50:00

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MG-115 Properties

Boiling point	678.8±55.0 °C(Predicted)
Density	1.082±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO: soluble
form	powder
pka	11.14±0.46(Predicted)
color	white

SAFETY

Risk and Safety Statements

WGK Germany	3

MG-115 price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	474780	MG-115 Potent reversible proteasome inhibitor (K	133407-86-0	5mg	$259	2024-03-01	Buy
Sigma-Aldrich	C6706	Z-Leu-Leu-Norvalinal ≥90% (HPLC), powder	133407-86-0	1mg	$99.3	2023-06-20	Buy
Cayman Chemical	15413	(S)-MG115 ≥95%	133407-86-0	1mg	$51	2024-03-01	Buy
Cayman Chemical	15413	(S)-MG115 ≥95%	133407-86-0	5mg	$128	2024-03-01	Buy
Cayman Chemical	15413	(S)-MG115 ≥95%	133407-86-0	10mg	$229	2024-03-01	Buy

Product number	Packaging	Price	Buy
474780	5mg	$259	Buy
C6706	1mg	$99.3	Buy
15413	1mg	$51	Buy
15413	5mg	$128	Buy
15413	10mg	$229	Buy

MG-115 Chemical Properties,Uses,Production

Description

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (K_i = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.

Uses

(S)-MG115 is a potent and reversible proteasome inhibitor, targeting the chymotryptic site on the 20S particle (Ki = 21 nM). It reduces the degradation of ubiquitin-conjugated proteins in extracts. (S)-MG115 also blocks the degradation of long- and short-lived proteins in intact cells as well as the proteolytic generation of diverse proteins, including NF-κB, antigens, and p53. Proteasome inhibitors, including (S)-MG115, can induce a heat shock response and apoptosis, particularly in cancer cells.[Cayman Chemical]

Uses

MG-115 is a compound that inhibits the chymotrypsin-like activity of the proteasome.

Definition

ChEBI: N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxopentan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamic acid (phenylmethyl) ester is a peptide.

General Description

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Biochem/physiol Actions

Product does not compete with ATP.

References

1. involvement of heat shock protein 90 in the degradation of mutant insulin receptors by the proteasome. imamura, t., haruta, t., takata, y., usui, i., iwata, m., ishihara, h., ishiki, m., ishibashi, o., ueno, e., sasaoka, t., kobayashi, m. j. biol. chem. (1998)

MG-115 Preparation Products And Raw materials

Raw materials

Preparation Products

MG-115 Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Alabiochem Tech.Co., Ltd.	0512-58900862 400-0707518	sales@alabiochem.com	China	995	59
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ApexBio Technology LLC	+1-832-696-8203	info@apexbt.com	United States	477	60

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Nextpeptide Inc	58
Nantong HI-FUTURE Biology Co., Ltd.	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58
Aladdin Scientific	58
Aladdin Scientific	58
Alabiochem Tech.Co., Ltd.	59
Guangzhou Isun Pharmaceutical Co., Ltd	55
ApexBio Technology LLC	60

MG-115 Spectrum

MG-115(133407-86-0)MS MG-115(133407-86-0)¹HNMR

133407-86-0(MG-115)Related Search:

Trypsin trysin-chymotrypsin Basic protease LACTACYSTIN MG-115

MG-132 Z-LLL-AMC Z-LEU-LEU-ARG-AMC Z-LEU-LEU-4,5-DEHYDRO-LEU-ALDEHYDE Z-LEU-LEU-GLU-7-AMINO-4-TRIFLUOROMETHYLCOUMARIN

MG-262 Z-LEU-LEU-GLU-AMC Z-LEU-LEU-LEU-FMK N-CBZ-LEU-LEU-GLU BETA-NAPHTHYLAMIDE GAMMA-SECRETASE INHIBITOR

1 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE) 5 MG PROTEASOME INHIBITOR MG-115Z-LEU-LEU-NVA-H(ALDEHYDE)

1of4

PROTEASOME INHIBITOR MG-115 N-CBZ-LEU-LEU-NORVALINAL MG-115 Z-LL-NVA-CHO Z-LEU-LEU-NVA-ALDEHYDE Z-LEU-LEU-NVA-CHO Z-LEU-LEU-NVA-H Z-LEU-LEU-NVA-H (ALDEHYDE) CARBOBENZOXY-L-LEUCYL-L-LEUCYL-L-NORVALINAL CARBOBENZOXY-L-LEUCYL-L-LEUCYL-NORVALINAL BENZYLOXYCARBONYL-L-LEUCYL-L-LEUCYL-L-NORVALINAL z-leu-leu-norvalinal N-carbobenzyloxy-Leu-Leu-norvalinal MG115, Z-LLnV Z-Leu-Leu-Norvalinal,MG115, Z-LLnV (S)-MG115 Z-LLnV L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formylbutyl]- MG-115 - CAS 133407-86-0 - Calbiochem MG-115 (DMSO solution) 133407-86-0 C25H39N3O5 Inhibitors BioChemical Biochemicals and Reagents Application Index Cell Signaling Enzymes Proteasome, Calpain and Lysosomal Proteases Proteasomes Enzymes, Inhibitors, and Substrates Calpain and Lysosomal Proteases Proteasome Inhibitors Aldehydes and Substrates Application Index Bioactive Small Molecules Biochemicals and Reagents Building Blocks C13-C60 Calpain and Proteasome Inhibitors Carbonyl Compounds Cell Biology Cell Signaling and Neuroscience Cell Signaling Enzymes Chemical Synthesis Endoplasmic Reticulum Stress Enzymes Inhibitors Intracellular Protein Degradation Nitric Oxide and Cell Stress Organic Building Blocks Proteasome Proteasomes Z ProteasomeInhibitors peptides