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Candesartan

CAS No.
139481-59-7
Chemical Name:
Candesartan
Synonyms
Atacend;CV-11974;CILEXITIL;CANDESARTAN;tandishatan;Candesartan M1;Candesartan 98%;Candesartan Base;Candesartan (C8);Candesartan (Atacand)
CBNumber:
CB0209324
Molecular Formula:
C24H20N6O3
Molecular Weight:
440.45
MDL Number:
MFCD00864463
MOL File:
139481-59-7.mol
Last updated:2024-03-22 14:56:24

Candesartan Properties

Melting point 183-185°C
Boiling point 754.8±70.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
RTECS DD6671000
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 40 mg/ml)
form solid
pka 2.06±0.10(Predicted)
color White
Water Solubility Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference 139481-59-7(CAS DataBase Reference)
FDA UNII S8Q36MD2XX
ATC code C09CA06

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335
Precautionary statements  P261-P280-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-60-36/37-9
HS Code  29419000

Candesartan price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J62818 Candesartan, 98% 139481-59-7 100mg $68.1 2024-03-01 Buy
Alfa Aesar J62818 Candesartan, 98% 139481-59-7 1g $284.65 2024-03-01 Buy
Tocris 4791 Candesartan ≥98%(HPLC) 139481-59-7 50 $324 2021-12-16 Buy
Tocris 4791 Candesartan ≥98%(HPLC) 139481-59-7 10 $75 2021-12-16 Buy
TRC C175575 Candesartan 139481-59-7 100mg $65 2021-12-16 Buy
Product number Packaging Price Buy
J62818 100mg $68.1 Buy
J62818 1g $284.65 Buy
4791 50 $324 Buy
4791 10 $75 Buy
C175575 100mg $65 Buy

Candesartan Chemical Properties,Uses,Production

Description

Candesartan (CAS 139481-59-7) is an angiotensin II receptor I (AT1) antagonist, IC50s=1.12 and 2.86 nM for bovine adrenal cortex and rabbit aorta respectively.1?Selectively inhibits angiotensin II-induced contraction of rabbit aortic strips with no effect on contraction induced by other agents such as norepinephrine, KCl, serotonin, PGF2αor endothelin. Prevents astrocyte and microglial activation and neuroinflammation and improves hippocampal neurogenesis.2?Attenuates angiogenesis in hepatocellular carcinoma.3?Clinically useful antihypertensive agent. Ameliorates brain inflammation associated with Alzheimer’s disease.4?Active?in vivo?and orally active.

Chemical Properties

Crystalline Solid

Uses

Candesartan is a selective AT1 (angiotensin II receptor 1) antagonist. Antagonism of angiotensin receptors inhibits vasoconstriction and the production of aldosterone, leading to a decrease in water and sodium concentration in blood plasma. Exhibits antihypertensive effects in animal models. Used in treatment of congestive heart failure, as antihypertensive. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

Uses

antihypertensive, angiotensin II inhibitor

Uses

An angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive

Definition

ChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.

brand name

Atacand (AstraZeneca).

General Description

Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic tetrazole system,which most likely plays a role in binding to the angiotensin IIreceptor similarly to the acidic groups of angiotensin II. Also,the imidazole system has been replaced with a benzimidazolepossessing an ester at position. This ester must be hydrolyzedto the free acid. Fortunately, this conversion takesplace fairly easily because of the carbonate in the ester sidechain. This facilitates hydrolysis of the ester so much thatconversion to the free acid takes place during absorption fromthe gastrointestinal tract.

storage

Store at RT

References

1) Shibouta?et al.?(1993),?Pharmacological profile of a highly potent and long-acting angiotension II receptor antagonist, 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazol-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116); J. Pharmacol. Exp. Therap.,?266?114 2) Bhat?et al. (2017),?Angiotensin receptor Blockade by Inhibiting Glial Activation Promotes Hippocampal Neurogenesis Via Activation of Wnt/B-Catenin signaling in hypertension; Mol. Neurobiol.,?55 5282 3) Fan?et al.?(2016),?Candesartan attenuates angiogenesis in hepatocellular carcinoma via downregulating AT1R/VEGF pathway; Biomed. Pharmacother.,?83?704 4) Torika?et al.?(2018),?Candesartan ameliorates brain inflammation associated with Alzheimer’s disease; CNS Neurosci. Ther.?24?231

Candesartan Preparation Products And Raw materials

Global( 489)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5990 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 5505 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Standardpharm Co. Ltd.
86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
Antai Fine Chemical Technology Co.,Limited
18503026267 info@antaichem.com CHINA 9641 58

View Lastest Price from Candesartan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Candesartan pictures 2024-03-23 Candesartan
139481-59-7
US $33.00-1.50 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Candesartan pictures 2023-09-26 Candesartan
139481-59-7
US $50.00-2.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
Candesartan pictures 2023-09-06 Candesartan
139481-59-7
US $0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • Candesartan pictures
  • Candesartan
    139481-59-7
  • US $33.00-1.50 / kg
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • Candesartan pictures
  • Candesartan
    139481-59-7
  • US $50.00-2.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • Candesartan pictures
  • Candesartan
    139481-59-7
  • US $0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.

Candesartan Spectrum

1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-ethoxy-1H-benzo[d]iMidazole-7-carboxylic acid 2-ethoxy-3-[[4-[2-(1h-tetrazol-5-yl)phenyl]phenyl]methyl]-3h-benzoimidazole-4-carboxylic acid 3-[[2'-(1H-Tetrazol-5-yl)biphenyl-4-yl]Methyl]-2-ethoxy-3H-benziMidazole-4- carboxylic Acid Candesartan M1 2-ETHOXY1-2(1H-TETRAZOL-5YL)1,1-BIPHENYL)-4-YL)-4-YL)METHYL)1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID Candesartan Cilexetil EP IMpurity G 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxy Candesartan Base 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)(1,1'-BIPHENYL)-4-YL]METHYL]-1H-BENZIMIDAZOLE-7-CARBOXYLIC ACID Candesartan[CandesartanCilexetilIntermediates] Candesartan ( For Candesartan Cilexetil ) CANDESARTAN CV-11974 CILEXITIL 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid, CV-11974 2-Ethoxy-1-[2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl-methyl]benzimidazole-7-carboxylicacidcyclohexyl-1-chloroethylcarbonate 2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl] 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl] Atacend 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazol-7-carboxylic acid (±)-2-Ethoxy-1-[[2’-(1H-tetrazol-5-y1)[1,l'-biphenyl]-4-y1]methyl]-1H-benzimidazole-7-earboxylic acid 3-(2'-Cyano-biphenyl-4-ylMethyl)-2-ethoxy-3H-benzoiMidazole-4-carboxylic acid Me 2-ethoxy-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}Methyl)-1H-1,3-benzodiazole-7-carboxylic acid Candesartan (Atacand) Candesartan 98% Candesartan (Candesartan Cilexetil impurity G) Candesartan Solution, 1000ppm Candesartan Cilexetil Impurity 7(EP Impurity G) Candesartan Solution, 100ppm tandishatan Candesartan Cilexetil EP Impurity G(Candesartan) 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 2-Ethoxy-1-[[(2′-(1Htetrazol-5-Yl)Biphenyl-4-Yl-) Methyl]Benzimidazole-7-Carboxylic Acid Candesartan (C8) 1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid Candesartan USP/EP/BP Cesartan intermediates Candesartan EP Impurity G Candesartan Cilexetil EP Impurity G (Candesartan Acid) Candesartan Impurity -G Candesartan Cilexetil EP Impurity G High Quality Intermediates Candesartan CAS: 139481-59-7 Candesartan (CV 11974) candesartan cilexetil impurity1364 CandesartanQ: What is Candesartan Q: What is the CAS Number of Candesartan Q: What is the storage condition of Candesartan Q: What are the applications of Candesartan Candesartan Cilexetil Related Compound G (1-{[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-ethoxybe (1087870) Candesartan Cilexetil USP Related Compound G Candesartan Cilexetil Impurity 7(Candesartan Cilexetil EP Impurity G) 3-((2'-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylic acid [CS-VII (Acid) 139481-59-7 C24H20N6O3 Isotope Pharmaceutical raw material Aromatics Heterocycles Bases & Related Reagents Intermediates & Fine Chemicals