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ChemicalBook >> CAS DataBase List >>Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Structure
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate structure
CAS No.
161797-99-5
Chemical Name:
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Synonyms
ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Febuxostat-8;Febuxostat Impurity A-1;3-thiazole-5-carboxylate;ethyl 2-(4-hydroxyphenyl);Intermediates of Febuxostat;Intermediate 2 of non brucite;Febuxostat Desaldehyde Impurity;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1;Febuxostat Descyano Hydroxy Ethyl Ester
CBNumber:
CB02128586
Molecular Formula:
C13H13NO3S
Molecular Weight:
263.31
MDL Number:
MFCD03700424
MOL File:
161797-99-5.mol
MSDS File:
SDS
Last updated:2024-03-25 10:07:45
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Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Properties

Melting point 180 ºC
Boiling point 426.8±55.0 °C(Predicted)
Density 1.274
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Very Slightly)
form Solid
pka 8.56±0.15(Predicted)
color Off-White
CAS DataBase Reference 161797-99-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
NFPA 704
1
2 0

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar H52223 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97% 161797-99-5 1g $110 2021-12-16 Buy
Alfa Aesar H52223 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate, 97% 161797-99-5 5g $439 2021-12-16 Buy
TRC E918910 Ethyl2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 5g $395 2021-12-16 Buy
TRC E918910 Ethyl2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 2.5g $210 2021-12-16 Buy
AK Scientific X8013 Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 161797-99-5 100g $316 2021-12-16 Buy
Product number Packaging Price Buy
H52223 1g $110 Buy
H52223 5g $439 Buy
E918910 5g $395 Buy
E918910 2.5g $210 Buy
X8013 100g $316 Buy

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Synthesis

A mixture of 4-cyanophenol, NaOH, and ethanol was mixed in a pressure bottle while heated to 80° C. Hydrogen sulfide gas was then introduced, and the pressure increased to 30-60 psi until the thioamidation was determined to be complete by HPLC. Without isolating the thioamide product, HCl was added to the bottle until the pH was below 3.5, the H2S gas was removed, and the bottle was placed under a vacuum for 20 minutes at 30-40° C. The reaction was then heated to 70° C, and ethyl 2-chloroacetoacetate(1.1 eq.) was added to the reaction solution. The reaction was mixed under reflux for 2-3 hours, treated with enough H2O to dissolve the NaCl salt in the reaction mixture, cooled to room temperature, treated with enough water to precipitate the product, and the solid was collected by filtration. The precipitate was washed with water and dried at 80° C. with nitrogen bleeding to provide Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate. ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Preparation Products And Raw materials

Raw materials

4-Cyanophenol 4-HYDROXYTHIOBENZAMIDE

Preparation Products

Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Suppliers

Global( 361)Suppliers
Supplier Tel Email Country ProdList Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 951 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
hebei hongtan Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
career henan chemical co 		58

View Lastest Price from Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate pictures 2024-04-22 ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
161797-99-5
 US $30.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate pictures 2024-03-28 Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
161797-99-5
 US $0.00 / kg 25kg 98%-99% Inquiry PNP Biotech Co. Ltd
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate pictures 2024-01-02 ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
161797-99-5
 US $70.00-700.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd

161797-99-5(Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate)Related Search:

ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-[3-(AMinocarbonyl)-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Descyano Impurity isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate 2-(4-HYDROXY-PHENYL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID
FeBuxostat Impurity 18 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid Febuxostat Impurity 8 Methyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Febuxostat Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 3-Cyano-4-(2-methylpropoxy)benzenecarbothioamide Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate 4-HYDROXYTHIOBENZAMIDE
ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE 4-Methylthiazole

1of4

ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester 5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester Intermediates of Febuxostat Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Descyano Hydroxy Ethyl Ester 3-thiazole-5-carboxylate Ethyl 2-(4-hydroxyphenyl)-4-methyl-1 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl ester ethyl 4-methyl-2-(4-oxocyclohexa-2,5-dien-1-ylidene)-3H-1,3-thiazole-5-carboxylate ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 2- Febuxostat Desaldehyde Impurity CAS 161797-99-5 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxytic acid ethyl Febuxostat intermediates，Ethyl 2-(4-hydroxyphenyl)-4- methylthiazole-5-carboxylate Ethyl2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate,97% ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carb Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Ethyl 2- Febuxostat-8 ethyl 2-(4-hydroxyphenyl) Febuxostat Impurity, Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate (G) ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate(G) Ethyl 2-(4-hydroxyphenyl)-4- ethylthiazole-5-carboxylate Intermediate 2 of non brucite Febuxostat Impurity A-1 Ethyl 2-(4-+B1:C32Hydroxyphenyl)-4-Methyl-5- Thiazolecarboxylate 161797-99-5 161798-99-5 Febuxostat Intermediates Febuxostat intermediate