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UTP

CAS No.
63-39-8
Chemical Name:
UTP
Synonyms
UTP-NA;UTP TRISODIUM SALT;pppU;5’-utp;uteplex;UTP, 3NA;Uracylic;UTP, NA3H;Urd-5'-P3;UTP Sodium
CBNumber:
CB0221667
Molecular Formula:
C9H15N2O15P3
Molecular Weight:
484.14
MDL Number:
MFCD00274571
MOL File:
63-39-8.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:03

UTP Properties

Density 2.106±0.06 g/cm3(Predicted)
Flash point 113 °C
storage temp. Sealed in dry,2-8°C
form liquid
pka pK1:7.58 (25°C)
color colorless
Water Solubility Water : ≥ 150 mg/mL (309.83 mM)
CAS DataBase Reference 63-39-8(CAS DataBase Reference)
FDA UNII UT0S826Z60
EPA Substance Registry System Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)

SAFETY

Risk and Safety Statements

Hazard Codes  Xn
Risk Statements  20/21/22-68/20/21/22
Safety Statements  22-26-36
WGK Germany  1

UTP price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich U1006 Uridine 5′-triphosphate trisodium salt solution HPLC purified, aqueous solution for RNA polymerase transcription 63-39-8 25μmol $123 2024-03-01 Buy
Usbiological 366675 Uridine Triphosphate 63-39-8 96Tests $954 2021-12-16 Buy
American Custom Chemicals Corporation APN0000293 URIDINE 5'-TRIPHOSPHATE 95.00% 63-39-8 1G $1428 2021-12-16 Buy
Biorbyt Ltd orb573355 UTP, Trisodium Salt >98% 63-39-8 1g $912.9 2021-12-16 Buy
ChemScene CS-7777 Uridinetriphosphate ≥98.0% 63-39-8 100mg $120 2021-12-16 Buy
Product number Packaging Price Buy
U1006 25μmol $123 Buy
366675 96Tests $954 Buy
APN0000293 1G $1428 Buy
orb573355 1g $912.9 Buy
CS-7777 100mg $120 Buy

UTP Chemical Properties,Uses,Production

Description

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

Occurrence

Uridine 5'-triphosphate is a natural product found in Helianthus tuberosus, Apis cerana, and other organisms with data available.

Uses

Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

Definition

UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-triphosphate and a uridine 5'-phosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).

Biochem/physiol Actions

P2Y receptor agonist

Pharmacokinetics

INS316 is a short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction that leads to chloride ion secretion, thereby resulting in mucociliary clearance of airway.

in vitro

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K.

in vivo

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes.

References

[1]. Lamarca A, et al. Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation. PLoS One. 2014 Jun 6;9(6):e98998.
[2]. Choi JH, et al. Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor. Pancreas. 2013 May;42(4):680-6.
[3]. Yitzhaki S, et al. Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function aftermyocardial infarct. Biochem Pharmacol. 2006 Oct 16;72(8):949-55.
[4]. Iwaki Y, et al. Enhancement of antibody production against rabies virus by uridine 5'-triphosphate in mice. Microbes Infect. 2014 Mar;16(3):196-202.

58-96-8
63-39-8
Synthesis of UTP from Uridine
Global( 138)Suppliers
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Zhejiang Hengkang Pharmaceutical Co., Ltd.
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changzhou huayang technology co., ltd
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View Lastest Price from UTP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Uridine 5'-Triphosphate pictures 2023-04-04 Uridine 5'-Triphosphate
63-39-8
US $0.00-0.00 / ml 1ml 99% 1000L per month Zhejiang Hengkang Pharmaceutical Co., Ltd.
UTP pictures 2021-08-12 UTP
63-39-8
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
UTP pictures 2019-08-30 UTP
63-39-8
US $1.00 / KG 1KG 98% 200kg Career Henan Chemical Co
  • UTP pictures
  • UTP
    63-39-8
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • UTP pictures
  • UTP
    63-39-8
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co
5'-URIDYLATE TRIPHOSPHATE UTP, 3NA UTP, NA3H UTP SODIUM SALT URIDINE 5'-TRIPHOSPHATE URIDINE-5'-TRIPHOSPHATE NA3-SALT URIDINE-5'-TRIPHOSPHATE SODIUM URIDINE 5'-TRIPHOSPHATE SODIUM SALT URIDINE 5-TRIPHOSPHATE TRISODIUM URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT URIDINE-5'-TRIPHOSPHORIC ACID, TRISODIUM 5’-utp uridine,5’-(tetrahydrogentriphosphate) uridine5’-triphosphoricacid uridinetriphosphate uteplex ({[(2S,3R,4S,5S)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)-3,4-dihydroxyoxolan-2-yl]Methyl phosphonato}oxy)(phosphonatooxy)phosphinate Uridine 5′-triphosphate trisodium salt solution Uracylic [[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid 5'-uridylate triphosphate (UTP) Uridine-5''-triphosphoric acid (and/or unspecified salts) Uridine 5μ-triphosphate solution trisodium salt pppU Urd-5'-P3 UTP .Free Acid Mix of 25 mM ATP, CTP, GTP and UTP Adenosine-5'-triphosphate, Sodium salt Uridine-5'-triphosphate Free acid UTP-NA UTP TRISODIUM SALT UTP Solution (100mM) ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate triphosphoric acid 1-uridin-5'-yl ester UTP Sodium UTP 200mM Tris Solution, GMP grade UTP 200mM Tris Solution UTP Sodium Solution,UltraNUcTM?NTPs 63-39-8 C9H15N2O15P3 Nucleotides DNA / RNA Synthesis NTP Elisa Kit-plant ELISA Kit