Xamoterol hemifumarate
- CAS No.
- 73210-73-8
- Chemical Name:
- Xamoterol hemifumarate
- Synonyms
- Carwin;Corwin;Xamtol;XAMOTEROL;ICI-118587;Corwin：Xamtol;Xamoterol hemifumara;Alfuzosin Impurity 9;XAMOTEROL HEMIFUMARATE;XAMOTEROL HEMIFUMARATE SALT
- CBNumber:
- CB0249700
- Molecular Formula:
- C36H54N6O14
- Molecular Weight:
- 794.85
- MDL Number:
- MFCD00661104
- MOL File:
- 73210-73-8.mol
- MSDS File:
- SDS
| Melting point | 168-169° (dec) |
|---|---|
| storage temp. | Store at RT |
| solubility | H2O: 10 mg/mL at 60 °C, soluble |
| form | solid |
| color | white |
| CAS DataBase Reference | 73210-73-8 |
| FDA UNII | N87007N668 |
| ATC code | C01CX07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
Xamoterol hemifumarate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24267 | Xamoterol (hemifumarate) ≥98% | 73210-73-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24267 | Xamoterol (hemifumarate) ≥98% | 73210-73-8 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 24267 | Xamoterol (hemifumarate) ≥98% | 73210-73-8 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 24267 | Xamoterol (hemifumarate) ≥98% | 73210-73-8 | 25mg | $420 | 2024-03-01 | Buy |
| Tocris | 0950 | Xamoterolhemifumarate ≥97%(HPLC) | 73210-73-8 | 50 | $767 | 2021-12-16 | Buy |
Xamoterol hemifumarate Chemical Properties,Uses,Production
Description
Xamoterol fumarate is a cardioselective partial beta-agonist, the first of its class to be developed for use in heart failure. The main advantage of xamoterol fumarate as a cardiotonic lies in the fact that its beta-blocking effect exerted during high sympathetic drive will protect the heart from overstimulation. It is claimed to be a viable but safer alternative to digoxin.
Description
Xamoterol is a partial agonist of β1-adrenergic receptors (β1-ARs) with an EC50 value of 80 nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures. It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM). In vivo, xamoterol increases heart rate in beagle dogs (ED50 = 3.2 μg/kg) and in a rat model of spontaneous heart failure (ED50 = 6 μg/kg), an effect that is reversed by the selective β1-AR antagonist betaxolol but not the selective β2-AR antagonist ICI 118551 . Formulations containing xamoterol have been used in the treatment of heart failure.
Originator
ICI (United Kingdom)
Uses
Xamoterol Hemifumarate, is a β1-adrenoceptor-selective partial agonist.
Uses
Stimulant (cardiac).
brand name
Corwin
Biological Activity
β 1 -adrenoceptor-selective partial agonist (pA 2 values are 7.4-7.8 and 5.2-6.2 at β 1 - and β 2 -adrenoceptors respectively).
storage
Store at RT
Xamoterol hemifumarate Preparation Products And Raw materials
Xamoterol hemifumarate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Mashilabs (Shanghai) Co.,Ltd. | 021-00000000 19916721580 | info@mashilabs.com | China | 4115 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |