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AZD-1208

AZD-1208 structure

CAS No.: 1204144-28-4

Chemical Name:: AZD-1208

Synonyms: CS-794;AZD1208;AZD 1208;AZD-1208;AZD1208 >=95%;AZD 1208;AZD-1208;AZD-1208 USP/EP/BP;AZD1208;AZD 1208;AZD-1208;(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione;(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione

CBNumber:: CB02666594

Molecular Formula:: C21H21N3O2S

Molecular Weight:: 379.48

MDL Number:: MFCD25976757

MOL File:: 1204144-28-4.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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AZD-1208 Properties

Melting point	>220°C (dec.)
Density	1.307±0.06 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly)
pka	7.39±0.20(Predicted)
form	Solid
color	Off-White to Pale Yellow
FDA UNII	S98NFM1378

AZD-1208 price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	20235	AZD 1208 ≥98%	1204144-28-4	1mg	$32	2024-03-01	Buy
Cayman Chemical	20235	AZD 1208 ≥98%	1204144-28-4	5mg	$78	2024-03-01	Buy
Cayman Chemical	20235	AZD 1208 ≥98%	1204144-28-4	10mg	$109	2024-03-01	Buy
Cayman Chemical	20235	AZD 1208 ≥98%	1204144-28-4	25mg	$230	2024-03-01	Buy
Tocris	6310	AZD1208 ≥98%(HPLC)	1204144-28-4	50	$386	2021-12-16	Buy

Product number	Packaging	Price	Buy
20235	1mg	$32	Buy
20235	5mg	$78	Buy
20235	10mg	$109	Buy
20235	25mg	$230	Buy
6310	50	$386	Buy

AZD-1208 Chemical Properties,Uses,Production

Uses

AZD1208 is a potent, and orally available Pim kinase inhibitor.

Biological Activity

upregulation of pim kinases has been observed in several types of leukemias and lymphomas. pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. azd1208 is a potent, highly selective, and orally available pim kinase inhibitor.

in vitro

azd1208 inhibited the growth of 5 of 14 acute myeloid leukemia (aml) cell lines tested. in molm-16 cells, azd1208 also causes cell cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of bcl-2 antagonist of cell death [1].

in vivo

azd1208 inhibits the growth of kg-1a and molm-16 xenograft tumors in vivo with a clear pk/pd relationship. treatment with 10 mg/kg or 30 mg/kg of azd1208 led to an 89% tumor growth inhibition or slight regression, respectively [1].

target

Pim1

IC 50

0.4 nm for pim-1, 5.0 nm for pim-2, and 1.9 nm for pim-3

storage

Store at -20°C

References

[1] keeton ek, mceachern k, dillman ks, palakurthi s, cao y, grondine mr, kaur s, wang s, chen y, wu a, shen m, gibbons fd, lamb ml, zheng x, stone rm, deangelo dj, platanias lc, dakin la, chen h, lyne pd, huszar d. azd1208, a potent and selective pan-pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. blood. 2014;123(6):905-13.

AZD-1208 Preparation Products And Raw materials

Raw materials

Preparation Products

AZD-1208 Suppliers

Global( 124)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29016	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
changzhou huayang technology co., ltd	58
InvivoChem	58

View Lastest Price from AZD-1208 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-02	AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione 1204144-28-4	US $1.00-1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione
1204144-28-4
US $1.00-1.00 / KG
98%
Career Henan Chemical Co

AZD-1208 Spectrum

AZD-1208(1204144-28-4)MS

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AZD 1208 AZD1208 AZD-1208 (5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione (5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione AZD1208 (R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione (R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione AZD1208 >=95% (5Z)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione AZD1208;AZD 1208;AZD-1208 CS-794 AZD 1208;AZD-1208 2,4-Thiazolidinedione, 5-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-, (5Z)- AZD-1208 USP/EP/BP (R,Z)-5-((2-(3-Aminopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)methylene)thiazolidine-2,4-dione 1204144-28-4 Inhibitors JAK STAT JAK/STAT