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LDC1267

LDC1267 structure

CAS No.: 1361030-48-9

Chemical Name:: LDC1267

Synonyms: CS-1641;LDC1267;LDC 1267;LDC-1267;LDC1267 USP/EP/BP;LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer;N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide;1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-

CBNumber:: CB02734808

Molecular Formula:: C30H26F2N4O5

Molecular Weight:: 560.55

MDL Number:: MFCD28385861

MOL File:: 1361030-48-9.mol

Last updated:2023-05-21 10:59:17

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LDC1267 Properties

Boiling point	628.4±55.0 °C(Predicted)
Density	1.32±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
form	solid
pka	9.36±0.70(Predicted)

LDC1267 price More Price(14)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	29459	LDC-1267	1361030-48-9	1mg	$36	2024-03-01	Buy
Cayman Chemical	29459	LDC-1267	1361030-48-9	25mg	$553	2024-03-01	Buy
Cayman Chemical	29459	LDC-1267	1361030-48-9	5mg	$145	2024-03-01	Buy
Cayman Chemical	29459	LDC-1267	1361030-48-9	10mg	$239	2024-03-01	Buy
AK Scientific	1703DN	CID56847486	1361030-48-9	5mg	$260	2021-12-16	Buy

Product number	Packaging	Price	Buy
29459	1mg	$36	Buy
29459	25mg	$553	Buy
29459	5mg	$145	Buy
29459	10mg	$239	Buy
1703DN	5mg	$260	Buy

LDC1267 Chemical Properties,Uses,Production

Biological Activity

LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.

in vitro

LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

in vivo

In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.

target

Target	Value
Mer (Cell-free assay)	<5 nM
Tyro3 (Cell-free assay)	8 nM
Axl (Cell-free assay)	29 nM

LDC1267 Preparation Products And Raw materials

Raw materials

Preparation Products

LDC1267 Suppliers

Global( 80)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29525	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

LDC1267 Spectrum

LDC1267(1361030-48-9)¹HNMR

1361030-48-9(LDC1267)Related Search:

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LDC1267 N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide CS-1641 LDC 1267;LDC-1267 1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)- LDC1267 USP/EP/BP N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide LDC 1267,LDC1267,Tyro3,Inhibitor,LDC-1267,inhibit,TAM Receptor,Axl,Mer 1361030-48-9 136030-48-9 C30H26F2N4O5 Inhibitors