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Formononetin

CAS No.
485-72-3
Chemical Name:
Formononetin
Synonyms
7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one;ForMonentin;Formononetine;Formononetin (50 mg);Myconate;Flavosil;Mycotech;biocanin;NSC 93360;NEOCHANIN
CBNumber:
CB0331896
Molecular Formula:
C16H12O4
Molecular Weight:
268.26
MDL Number:
MFCD00016948
MOL File:
485-72-3.mol
Last updated:2024-01-05 11:48:35

Formononetin Properties

Melting point 256-260 °C
Boiling point 331.43°C (rough estimate)
Density 1.1529 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.4350 (estimate)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 100 mg/ml).
form Powder
pka 6.99±0.20(Predicted)
color White to light beige
λmax 300nm(EtOH)(lit.)
Merck 14,4244
BRN 237979
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey HKQYGTCOTHHOMP-UHFFFAOYSA-N
LogP 1.7 at 25℃
CAS DataBase Reference 485-72-3(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 295DQC67BJ
EPA Substance Registry System 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (485-72-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26-36
WGK Germany  3
RTECS  DJ3100114
HS Code  29329990

Formononetin price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 47752 Formononetin ≥99.0% (TLC) 485-72-3 5mg $133 2024-03-01 Buy
Sigma-Aldrich 47752 Formononetin ≥99.0% (TLC) 485-72-3 25mg $489 2024-03-01 Buy
Sigma-Aldrich 344215 Formononetin A phytoestrogenic isoflavone found in soy-based foods. 485-72-3 5mg $113 2024-03-01 Buy
Sigma-Aldrich 1286060 Formononetin United States Pharmacopeia (USP) Reference Standard 485-72-3 50mg $1070 2024-03-01 Buy
TCI Chemical F0868 Formononetin >98.0%(HPLC)(T) 485-72-3 1g $133 2024-03-01 Buy
Product number Packaging Price Buy
47752 5mg $133 Buy
47752 25mg $489 Buy
344215 5mg $113 Buy
1286060 50mg $1070 Buy
F0868 1g $133 Buy

Formononetin Chemical Properties,Uses,Production

Description

Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5

Chemical Properties

off-white powder

Uses

An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen.

Uses

Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity.

Uses

Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen.

Definition

ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-).

General Description

Formononetin belongs to the isoflavones class of polyphenols.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa.

References

1) Nie?et al.?(2018),?The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol.,?175?1439 2) Gautam?et al.?(2017),?Formononetin, an isoflavone, activates AMO-activated protein kinase/?β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit.,?117?645 3) Huh?et al. (2011),?Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol.,?11?46 4) Ong?et al.?(2019),?Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel),?11?E611 5) Li?et al.?(2018),?Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother.,?106?349

2632-13-5
95-01-2
485-72-3
Synthesis of Formononetin from 2-Bromo-4'-methoxyacetophenone and 2,4-Dihydroxybenzaldehyde

Formononetin Preparation Products And Raw materials

Global( 457)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567 +86-17782035140 sales@zhswyy.com China 382 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691 yklbiotech@163.com CHINA 296 58

View Lastest Price from Formononetin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Formononetin pictures 2024-03-28 Formononetin
485-72-3
US $0.00 / MG 10MG 98% HPLC 100KG Changsha Staherb Natural Ingredients Co., Ltd.
Formononetin pictures 2024-03-28 Formononetin
485-72-3
US $0.00 / kg 25kg HPLC>99% Inquiry PNP Biotech Co. Ltd
Formononetin pictures 2024-03-27 Formononetin
485-72-3
US $0.00-0.00 / kg 0.10000000149011612kg ≥98%HPLC 20tons Chongqing Zhihe Biopharmaceutical Co., Ltd.
  • Formononetin pictures
  • Formononetin
    485-72-3
  • US $0.00 / MG
  • 98% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Formononetin pictures
  • Formononetin
    485-72-3
  • US $0.00 / kg
  • HPLC>99%
  • PNP Biotech Co. Ltd
  • Formononetin pictures
  • Formononetin
    485-72-3
  • US $0.00-0.00 / kg
  • ≥98%HPLC
  • Chongqing Zhihe Biopharmaceutical Co., Ltd.
red clover extract_formononetin Flavosil Myconate NSC 93360 ForMononetin (ForMononetol) ForMoononetin 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-4μ-methoxyisoflavone Formononetin,Formoononetin 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- Daidzein 4'-methyl ether Formononetin ,98% 4'-Methoxy-7-hydroxyisoflavone 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one Formononetin,99% Mycotech forMonoetin ForMononetin, 99% 1GR ForMononetin SynonyMs 7-Hydroxy-3-(4-Methoxyphenyl)chroMone Formononetin 7-Hydroxy-3-(4-methoxyphenyl)chromone NEOCHANIN 7-HYDROXY-3-(4'-METHOXYPHENYL)-4H-BENZOPYRAN-4-ONE 7-HYDROXY-3-(4-METHOXYPHENYL)CHROMEN-4-ONE 7-HYDROXY-3-(4-METHOXYPHENYL)CHROMONE 7-HYDROXY-4'-METHOXYISOFLAVANONE 7-HYDROXY-4'-METHOXYISOFLAVONE 7-HYDROXY-4'-METHOXYUSIFLAVONE AKOS BBS-00006073 BIOCHANIN B DADEIN 4'-METHYL ETHER FORMONONETIN FORMONONETOL 7-hydroxy-3-(4-methoxyphenyl)-4-benzopyrone Formononetin by synthesis FORMONONETIN 99% BiocaninB FORMONETIN 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-3-(4-methoxyphenyl)chromone FORMONONETIN WITH HPLC FORMONONETIN, NATURAL Formononetin 98.0%min 3-(4-methoxyphenyl)- FORMONONETIN hplc Trifolium pratensel L 7-hydroxy-3-(4-methoxyphenyl)-1-benzopyran-4-one Formononetin 485-72-3 Formononetin - CAS 485-72-3 - Calbiochem Formononetin, 98%, reagent grade Formononetin> FPRMONONETIN 7-Hydroxy-4'-methoxyisoflavone (Formononetin) Formononetin (Biochanin B) Formononetin (1286060) ForMonentin 7-hydroxy-3-(4-Methoxyphenyl)-4H-chroMen-4-one Formononetine Formononetin (50 mg) biocanin 7- Hydroxy -4'- methoxy Isoflavone (or ) Formonetin