Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>ANGIOTENSIN II, HUMAN

ANGIOTENSIN II, HUMAN

ANGIOTENSIN II, HUMAN Structure
ANGIOTENSIN II, HUMAN structure
CAS No.
4474-91-3
Chemical Name:
ANGIOTENSIN II, HUMAN
Synonyms
ANGIOTENSIN II;Ang II;DRVYIHPF;TY-10721;AngiotensinⅡ;ANGIOTENSIN-2;H-DRVYIHPF-OH;angiotensin renin;ANTI-ANGIOTENSIN II;ile(5)-angiotensini
CBNumber:
CB0338057
Molecular Formula:
C50H71N13O12
Molecular Weight:
1046.2
MDL Number:
MFCD00161484
MOL File:
4474-91-3.mol
MSDS File:
SDS
Last updated:2024-04-19 20:05:26
Request For Quotation

ANGIOTENSIN II, HUMAN Properties

Boiling point 809.08°C (rough estimate)
Density 1.1257 (rough estimate)
refractive index 1.6700 (estimate)
RTECS BW2165000
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility insoluble in DMSO; insoluble in EtOH; ≥100.2 mg/mL in H2O
form Powder
pka pK1: 10.37 (25°C)
color orange
Water Solubility Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
Sequence H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Stability Hygroscopic
InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
EWG's Food Scores 1
FDA UNII M089EFU921
ATC code C01CX09

SAFETY

Risk and Safety Statements

WGK Germany  3

ANGIOTENSIN II, HUMAN price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A9525 Angiotensin II human ≥93% (HPLC), powder 4474-91-3 1mg $38.4 2024-03-01 Buy
Sigma-Aldrich A9525 Angiotensin II human ≥93% (HPLC), powder 4474-91-3 5x1mg $154 2024-03-01 Buy
Sigma-Aldrich A9525 Angiotensin II human ≥93% (HPLC), powder 4474-91-3 25MG $308 2024-03-01 Buy
Sigma-Aldrich 05-23-0101 Angiotensin II, Human - CAS 4474-91-3 - Calbiochem Plays an important role in the regulation of blood pressure. 4474-91-3 1mg $57.8 2024-03-01 Buy
Sigma-Aldrich 05-23-0101 Angiotensin II, Human - CAS 4474-91-3 - Calbiochem Plays an important role in the regulation of blood pressure. 4474-91-3 5mg $72.8 2024-03-01 Buy
Product number Packaging Price Buy
A9525 1mg $38.4 Buy
A9525 5x1mg $154 Buy
A9525 25MG $308 Buy
05-23-0101 1mg $57.8 Buy
05-23-0101 5mg $72.8 Buy

ANGIOTENSIN II, HUMAN Chemical Properties,Uses,Production

Discovery

Angiotensin II is the active peptide hormone of the reninangiotensin system (RAS) with broad functions, including a vasopressor effect and thirst stimulation. It is a drug target for hypertension and renal diseases. In 1940, two groups of researchers separately discovered a potent vasoconstrictor by incubating plasma with renin; the substance was named both “angiotonin” and “hypertensin.” In 1958, they agreed to rename it “angiotensin” (angio=blood vessel; tensin=tension).

Structure

Ang II is a linear peptide with no known secondary modification. Ang II is produced by the subsequent cleavage of angiotensinogen (AGT) by renin and angiotensin I (Ang I) by ACE (See Renin Angiotensin System). Mr. 1046 of Ang II in humans. Freely soluble in water.

Gene, mRNA, and mRNA

AGT is located on chromosome 1q42.2 in humans. AGT belongs to the SERPIN family A, member 8. AGT protein sequences are highly variable but the functional domains (Ang I) are relatively conserved among vertebrates. Ang I sequences were identified by the incubation of a renin source (kidney extract) and an angiotensinogen source (plasma). Lamprey Ang I with sequence NRVYVHPFTL was first sequenced using peptide purification. However, the lamprey genome data suggested a different Ang I sequence, and was later confirmed as the native AGT. The purified teleost-type Ang I produced in the buccal gland was suggested to be involved in endocrine mimicry to reduce host immunorejection.

Agonist

A nonpeptide ligand, L-162,313 was shown to bind to AT1A, AT1B, and the AT2 receptor and act as an agonist on AT1A and AT1B receptors in mice (34.9 and 23.3% of the maximum response of Ang II, respectively). Early studies used CGP42112A as the agonist for the AT2 receptor but compound 21, with little affinity for the AT1 receptor, was recently developed as a specific agonist of the AT2 receptor in humans.

Antagonist

Saralasin ([Sar1 ], [Ala8 ]-Ang II) is a partial agonist of angiotensin II receptors, though it is commonly mistaken as a competitive antagonist. Antagonists including losartan, irbesartan, olmesartan, candesartan, and valsartan are commonly used clinically as AT1 blockers. Two AT2 receptor antagonists, PD123177 (discontinued) and PD123319 (available), were developed to inhibit AT2 activities.

Biological functions

Ang II/AT1 axis mediates vasoconstriction, thirst, release of vasopressin and aldosterone, renal sodium reabsorption, fibrosis, inflammation, angiogenesis, vascular aging, and atherosclerosis. Ang II-induced effects included blood pressure control; drinking; adrenergic stimulation; modulation of the ion pump and transporter activities in the gill, kidney, and intestine in fish; control of the filtering nephron population in fish; and regulation of ventral skin absorption in amphibians. The injection of Ang II significantly increased ventral skin drinking in the frog. Lamprey Ang II is a vasodepressor instead of a vasopressor when injected intraarterially. The intracerebroventricular (ICV) injection of Ang II into the trout increased the systemic blood pressure, heart rate, and ventilation rate. The ICV injection of Ang II elicits tachycardia in contrast to bradycardia when injected peripherally. Central Ang II injection also inhibits the vagal-mediated baro-reflex, indicating that brain RAS is involved in the heart rate control.
The AT2 receptor is mostly embryonic. The expression decreases in adults and is confined in certain tissues such as the kidney. The effects of AT2 are often antagonistic to AT1, and activation of the AT2 receptor usually indicates a pathophysiological condition of AT1-mediated action with potential harmful consequences. AT2 is abundantly expressed in the spleen of the adult eel, which suggests an immune-related function.

Description

It is known that tumor tissues including metastatic lymph nodes are composed of newly growing vessels which lack blood flow autoregulation and are influenced only secondarily by the responding somatic vessels. Human angiotensin II (AT II). a vasopressor, was introduced in Japan to improve the efficacy of systemic chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg) followed by a bolus injection of conventional cytotoxic agents increases blood flow 5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue resulting in enhanced chemotherapeutic effects. This induced-hypertension chemotherapy regimen can be performed safely with minimal side effects.

Description

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.

Originator

Toa Eiyo (Japan)

Uses

Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.

Uses

A peptide involved in the regulation of blood pressure

Uses

Cardiopulmonary resuscitation - not yet an approved application

Definition

ChEBI: Ile(5)-angiotensin II is an angiotensin II that acts on the central nervous system (PDB entry: 1N9V). It has a role as a human metabolite. It is a tautomer of an Ile(5)-angiotensin II dizwitterion.

brand name

Delivert

General Description

Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.

Biochem/physiol Actions

Product does not compete with ATP.

Clinical Use

Renin antagonists, ACE inhibitors, and AT1 receptor blockers have been used, in singular or multiple blockade, to treat hypertension and other RAS-related diseases. High levels of Ang II are often related to hypertension, renal failure, and cardiac fibrosis.

in vitro

Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.

in vivo

To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption.

storage

-20°C (desiccate)

ANGIOTENSIN II, HUMAN synthesis

484-42-4
4474-91-3
7763-65-7
Synthesis of ANGIOTENSIN II, HUMAN from ANGIOTENSIN I, HUMAN

ANGIOTENSIN II, HUMAN Preparation Products And Raw materials

Raw materials

Phenprobamate Octanoic hydrazide Citric acid monohydrate Angiotensin L-Histidine
Sodium bicarbonate Tert-butyl ester Dicyclohexylcarbodiimide Boc-L-Histidine(Tosyl) Boc-Asp(Ochx)-OH
Fmoc-His(Trt)-OH BOC-HIS(TOS)-OH DCHA N-Boc-L-valine H-HIS-LEU-OH ANGIOTENSIN I, HUMAN
Boc-O-(2-bromo-Cbz)-L-Tyrosine

1of4

Preparation Products

L-Leucine, L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-

ANGIOTENSIN II, HUMAN Suppliers

Global( 231)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Xinhao Biotechnology Co., Ltd
+86-18120578002 +86-18120578002 xinhao-6@xinhaoshengwu.com China 350 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Shanghai Aosiris new Material Technology Co., LTD 		86-15139564871 +8615139564871 wrjmoon2000@163.com China 354 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Rixing Chemical CO.,LTD 		+86-13237129059 -13237129059 sales@rixingchemi.com CHINA 229 55
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Supplier Advantage
Wuhan Xinhao Biotechnology Co., Ltd
58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Shanghai Aosiris new Material Technology Co., LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Rixing Chemical CO.,LTD 		55
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from ANGIOTENSIN II, HUMAN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
angiotensin 2 pictures 2024-04-23 angiotensin 2
4474-91-3
 US $35.00 / box 1box >99% 20tons Hong Kong Excellence Biotechnology Co., Ltd.
angiotensin 2 pictures 2024-04-19 angiotensin 2
4474-91-3
 US $3.00-1.00 / kg 1kg 99.9% 10 tons Shanghai Aosiris new Material Technology Co., LTD
Angiotensin II, Human pictures 2024-04-02 Angiotensin II, Human
4474-91-3
 US $10.00-100.00 / kg 1kg 99% 100 tons Wuhan Xinhao Biotechnology Co., Ltd
  • angiotensin 2 pictures
  • angiotensin 2
    4474-91-3
  • US $35.00 / box
  • >99%
  • Hong Kong Excellence Biotechnology Co., Ltd.
  • angiotensin 2 pictures
  • angiotensin 2
    4474-91-3
  • US $3.00-1.00 / kg
  • 99.9%
  • Shanghai Aosiris new Material Technology Co., LTD

ANGIOTENSIN II, HUMAN Spectrum

ANGIOTENSIN II, HUMAN(4474-91-3)MSANGIOTENSIN II, HUMAN(4474-91-3)1HNMR

4474-91-3(ANGIOTENSIN II, HUMAN)Related Search:

ANGIOTENSIN II HUMAN ACETATE SALT,ANGIOTENSIN II, HUMAN, SYNTHETIC,angiotensin ii human acetate Angiotensin acetate ASP-ARG-VAL-TYR-ILE-HIS-PRO ANGIOTENSIN III, HUMAN ABZ-GLY-4-NITRO-PHE-PRO-OH
BZ-GLY-GLY-GLY-OH H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT ANGIOTENSIN I/II (4-8) H-MET-LYS-ARG-SER-ARG-GLY-PRO-SER-PRO-ARG-ARG-OH
ANGIOTENSIN I/II (1-6) ASP-ARG-VAL-TYR (DES-ASP1,ILE8)-ANGIOTENSIN II ANGIOTENSIN I/II (3-7) ANGIOTENSIN I/II (1-5)
Angiogenin (108-122) TFA BRADYKININ (1-6) ANGIOTENSINOGEN (1-13) (HUMAN)

1of4

[ILE5]-ANGIOTENSIN 2 HYPERTENSION II HUMAN L-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH FLUORESCEIN-NHCS-NH-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH 2CH3CHOOH H2O ANGIOTENSIN II, HUMAN ANGIOTENSIN II (HUMAN) ACOH 4H2O ANGIOTENSIN II, [ASN1,VAL5] ANGIOTENSIN II, DES-ASP1-[ILE8] ANGIOTENSIN II - FLUORESCEIN RBIOPROBE(TM) ANTI-ANGIOTENSIN II ANTI-ANGIOTENSIN II, HUMAN 5-l-isoleucine-angiotensini 5-l-isoleucineangiotensinii angiotensinii(mouse) ile(5)-angiotensini ANGIOTENSIN-2 H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH acetate salt ProteoMassTM Angiotensin II MALDI-MS Standard Angiotensin II-fluorescein human ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACOH 4H2O ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ANGIOTENSIN II, [SAR1,ALA8] ANGIOTENSIN II, [SAR1,ILE8] ANGIOTENSIN II, [SAR1,THR8] Vals-hypertensin-II-Asp-β-amide [Ile5]angiotensin II Angiotensin II【guinea pig】 Angiotensin II【rabbit】 TY-10721 Angiotensin 2 (Human Type) H-DRVYIHPF-OH ANGIOTENSIN II, HUMA HuMan angiotension Ⅱ Relative Molecular Weight Angiotensin II, 5-L-isoleucine- Angiotensin Acetate II Angiotensin II, Ang II ANGIOTENSIN II, HUMAN, OCTAPEPTIDE ANGIOTENSIN II, [VAL5] ProteoMass? Angiotensin II MALDI-MS Standard ANGIOTENSIN 2; ANGIOTENSIN RENIN; ANGIOTENSIN RECEPTOR; angiotensin renin HYPERTENSIN II;ANG II Angiotensin II trifluoroacetate salt H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH trifluoroacetate salt Angiotensin II, Human - CAS 4474-91-3 - Calbiochem ANGIOTENSIN II;HYPERTENSIN II;ANG II;DRVYIHPF Angiotensin?II impurity ANGIOTENSIN II, HUMAN USP/EP/BP 4474-91-3 ANGIOTENSIN II, HUMAN DRVYIHPF Ang II ANGIOTENSIN II (2S,5S,8S,11S,14S,17S)-2-((1H-Imidazol-5-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid Angiotensin II human,Apoptosis,Angiotensin Receptor,Inhibitor,inhibit Rabbit Anti-Angiotensin II antibody Peptide Angiotensin 2 Andangiotensin II Human Acetate AngiotensinⅡ