3-Bromopyruvic acid
- CAS No.
- 1113-59-3
- Chemical Name:
- 3-Bromopyruvic acid
- Synonyms
- 3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;2-Oxo-3-bromopropanoic acid;3-BROMO-2-OXOPROPIONIC ACID;beta-bromopyruvicacid;NSC 62343;NSC 11731
- CBNumber:
- CB0380692
- Molecular Formula:
- C3H3BrO3
- Molecular Weight:
- 166.96
- MDL Number:
- MFCD00002587
- MOL File:
- 1113-59-3.mol
- MSDS File:
- SDS
| Melting point | 77-82 °C |
|---|---|
| Boiling point | 223.4±23.0 °C(Predicted) |
| Density | 1.7314 (rough estimate) |
| refractive index | 1.4650 (estimate) |
| storage temp. | 2-8°C |
| solubility | water: soluble1g/10 mL, clear, colorless |
| form | White crystalline solid |
| pka | 1.84±0.54(Predicted) |
| color | White to Almost white |
| Water Solubility | Soluble in water, dimethyl sulfoxide, ethyl acetate and water. |
| BRN | 1746786 |
| InChIKey | PRRZDZJYSJLDBS-UHFFFAOYSA-N |
| CAS DataBase Reference | 1113-59-3(CAS DataBase Reference) |
| FDA UNII | 63JMV04GRK |
| EPA Substance Registry System | Propanoic acid, 3-bromo-2-oxo- (1113-59-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UZ0840000 | |||||||||
| F | 19-21 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29183000 | |||||||||
| NFPA 704 |
|
3-Bromopyruvic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 16490 | Bromopyruvic acid ≥98.0% | 1113-59-3 | 10g | $112 | 2024-03-01 | Buy |
| Sigma-Aldrich | 16490 | Bromopyruvic acid ≥98.0% | 1113-59-3 | 50g | $399 | 2024-03-01 | Buy |
| TCI Chemical | B1153 | 3-Bromopyruvic Acid >98.0%(T) | 1113-59-3 | 5g | $96 | 2024-03-01 | Buy |
| TCI Chemical | B1153 | 3-Bromopyruvic Acid >98.0%(T) | 1113-59-3 | 25g | $319 | 2024-03-01 | Buy |
| Alfa Aesar | L00720 | Bromopyruvic acid, 97% | 1113-59-3 | 2g | $39.2 | 2024-03-01 | Buy |
3-Bromopyruvic acid Chemical Properties,Uses,Production
Chemical Properties
Off-white solid
Uses
Bromopyruvic acid is used as an affinity label for cysteine residues and a potential anti-cancer agent. It is involved in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids and substituted pyranones. It plays a vital role as a cross-linker between nucleic acids and proteins. It is used as an anticancer agent for lung tumors.
Uses
3-Bromopyruvic acid is an intermediate of the fungicide thiabendazole. It was also used in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids.
Uses
Bromopyruvic Acid is a synthetic brominated derivative of pyruvic acid. Bromopyruvic Acid maybe a potential treatment for certain types of cancer as it has shown to be effective at eliminating aggress ive liver tumors.
Preparation
Synthesis method of 3-bromopyruvic acid: add a little concentrated sulfuric acid and solvent dichloromethane to pyruvic acid in a reaction flask, add bromine dropwise for about 3.5h and stir, a white precipitate is produced, then continue to stir for 1h, dilute with cyclohexane and petroleum ether, then cool the reaction mixture to get crystals, filter, wash with petroleum ether and dry to get the finished product of 3-bromopyruvic acid.
Definition
ChEBI: 3-bromopyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug It has a role as an alkylating agent and an antineoplastic agent. It is a 2-oxo monocarboxylic acid and an organobromine compound. It derives from a pyruvic acid. It is a conjugate acid of a 3-bromopyruvate.
General Description
Bromopyruvic acid is an affinity label for cysteine residues?. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.
storage
Store at -20°C
Purification Methods
Dry it by azeotropic distillation (with toluene), and then recrystallise it from dry CHCl3. Dry for 48hours at 20o (0.5 torr) over P2O5. Store it at 0o. [Labandiniere et al. J Org Chem 52 157 1987, Beilstein 3 III 1167.]
3-Bromopyruvic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Actchem Co., Ltd. | +8618762124502 | actchem@qq.com | China | 27 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
View Lastest Price from 3-Bromopyruvic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-02 | 3-Bromopyruvic acid
1113-59-3
|
US $80.00-800.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2023-09-06 | 3-Bromopyruvic acid
1113-59-3
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | |
 |
2023-08-30 | Bromopyruvic acid
1113-59-3
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 3-Bromopyruvic acid
1113-59-3
- US $80.00-800.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 3-Bromopyruvic acid
1113-59-3
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
-
- Bromopyruvic acid
1113-59-3
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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