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Spiramycin

CAS No.
8025-81-8
Chemical Name:
Spiramycin
Synonyms
LEUCOMYCIN;espiramicin;Spiramycine;Spiramycin Ep;KITASAMYCIN BASE;5337r.p.;r.p.5337;rovamycin;nsc-64393;provamycin
CBNumber:
CB0396400
Molecular Formula:
C43H74N2O14
Molecular Weight:
843.05
MDL Number:
MFCD01314545
MOL File:
8025-81-8.mol
Last updated:2024-03-16 16:30:04

Spiramycin Properties

Melting point 126-128 °C
Boiling point 914℃
alpha D20 -80° (methanol)
refractive index 81 ° (C=2, 10% AcOH)
Flash point >110°(230°F)
storage temp. 2-8°C
solubility ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
form powder
color white to light yellow
optical activity [α]/D -85 to -80° in water (Specific rotation (dry basis))
Water Solubility Soluble in methanol. Slightly soluble in water
Merck 14,8752
CAS DataBase Reference 8025-81-8
EWG's Food Scores 4
FDA UNII 71ODY0V87H
ATC code J01FA02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H303
Precautionary statements  P270-P301+P312-P403-P501c
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  1
RTECS  WG9400000
10
HS Code  29419090
Toxicity LD50 in rats (mg/kg): 9400 orally; 1000 s.c.; 170 i.v. (Sous)
NFPA 704
0
2 0

Spiramycin price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S9132 Spiramycin 8025-81-8 1g $109 2024-03-01 Buy
Sigma-Aldrich 46745 Spiramycin from Streptomyces sp. VETRANAL 8025-81-8 100mg $58.2 2024-03-01 Buy
TCI Chemical S0575 Spiramycin >90.0%(HPLC) 8025-81-8 5g $116 2024-03-01 Buy
TCI Chemical S0575 Spiramycin >90.0%(HPLC) 8025-81-8 25g $400 2024-03-01 Buy
Alfa Aesar J66194 Spiramycin 90% 8025-81-8 1g $54.7 2022-04-27 Buy
Product number Packaging Price Buy
S9132 1g $109 Buy
46745 100mg $58.2 Buy
S0575 5g $116 Buy
S0575 25g $400 Buy
J66194 1g $54.7 Buy

Spiramycin Chemical Properties,Uses,Production

Description

Spiramycin was found in the culture broth of Streptomyces ambofaciens by Rhone Poulenc in 1954 and its acetate was synthesized by Kyowa Hakko Kogyo Co. in 1965. This antibiotic consists of three closely related macrolide components, I, II, and III, whose ratio is 2 : 1 : 1. Spiramycin shows almost the same antimicrobial spectrum and activity as the other macrolides, but its acetate, acetylspiramycin, has much better pharmacokinetic properties and activity in vivo.

Chemical Properties

An antibiotic substance.

Originator

Rovamycine,Specia,France,1972

Uses

vitamin A

Uses

antibacterial

Uses

Spiramycin I (foromacidin A) is the major analogue of a complex of 16-membered macrocyclic lactones produced by S. ambofaciens and S. spiramyceticus that have broad spectrum antibiotic activity. Spiramycins are unusual among the macrocyclic lactones in that they contain two basic sugars. Spiramycin complex has been used in both human and animal health but its use has not been widespread.

Manufacturing Process

The process for producing spiramycin comprises inoculating an aqueous nutrient medium with a culture of the NRRL No. 2420, allowing aerobic fermentation to take place and separating from the culture medium the spiramycin thus formed. The culture medium also contains the antibiotic substance known as Congocidin which, however, does not possess the same useful properties as spiramycin and which can be isolated in crystalline form. The separation of the two antibiotic substances is readily achieved.

brand name

Rovamycin (Rhone-Poulenc Rorer).

Therapeutic Function

Antibacterial

Antimicrobial activity

Enterobacteriaceae are resistant. Spiramycin is also active against anaerobic species: Actinomyces israelii (MIC 2–4 mg/L), Cl. perfringens (MIC 2–8 mg/L) and Bacteroides spp. (MIC 4–14 mg/L). It is also active against Tox. gondii.

Hazard

Poison; moderately toxic; teratogen; muta- gen; can cause hypermotility, diarrhea, nausea, or vomiting.

Pharmaceutical Applications

A fermentation product of Streptomyces ambofaciens, composed of several closely related compounds. Spiramycin 1 is the major component (c. 63%); spiramycins 2 and 3 are the acetate and monopropionate esters, respectively. It is available for oral administration and as spiramycin adipate for intravenous infusion. Spiramycins are relatively stable in acid conditions. A derivative, acetylspiramycin, is available in Japan.

Pharmacokinetics

Oral absorption: Variable
Cmax 1 g oral: 2.8 mg/L after 2 h
Plasma half-life:4–8h
Volume of distribution :383 L
Plasma protein binding :15%
In healthy volunteers given 2 g orally followed by 1 g every 6 h, peak plasma levels were 1.0–6.7 mg/L. After 1 g orally the AUC was 10.8 mg.h/L, with an apparent elimination halflife of 2.8 h. It is widely distributed in the tissues. It does not reach the CSF. Levels 12 h after a dose of 1 g were 0.25 mg/L in serum, 5.3 mg/L in bone and 6.9 mg/L in pus. Levels of 10.6 mg/L have been found 4 h after dosing in saliva, and concentrations at least equal to those in the serum are seen in bronchial secretions. A concentration of 27 mg/g was found in prostate tissues after repeated dosage. Only 5–15% is recovered from the urine. Most is metabolized, but significant quantities are eliminated via the bile, in which concentrations up to 40 times those in the serum may be found.

Side effects

Spiramycin is generally well tolerated, the most common adverse reactions being gastrointestinal disturbances, notably abdominal pain, nausea and vomiting, rashes and sensitization following contact.

Spiramycin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 354)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hefei TNJ Chemical Industry Co.,Ltd.
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HubeiwidelychemicaltechnologyCo.,Ltd
18627774460 faith@widelychemical.com CHINA 742 58
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SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58

View Lastest Price from Spiramycin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Spiramycin pictures 2024-03-19 Spiramycin
8025-81-8
US $210.00-190.00 / kilograms 100kilograms 99% 100tons Hebei Dangtong Import and export Co LTD
Spiramycin pictures 2023-11-01 Spiramycin
8025-81-8
US $210.00 / kg 1kg 99% 20 tons Hangzhou ICH Biofarm Co., Ltd
Spiramycin pictures 2023-09-06 Spiramycin
8025-81-8
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • Spiramycin pictures
  • Spiramycin
    8025-81-8
  • US $210.00-190.00 / kilograms
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • Spiramycin pictures
  • Spiramycin
    8025-81-8
  • US $210.00 / kg
  • 99%
  • Hangzhou ICH Biofarm Co., Ltd
  • Spiramycin pictures
  • Spiramycin
    8025-81-8
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.

Spiramycin Spectrum

SPIRAMYCIN rovamycin provamycin FORMACIDINE foromacidin sequamycin spiramycin from streptomyces sp. Spiramycin solution spiramycin standard solution Spiramyein SPIRAMYCIN VETRANAL, 100 MG SpiramycinBaseEp97 2-[12-[5-(4,5-Dihydroxy-4,6-dimethyl-oxan-2-yl)oxy-4-dimethylamino-3-hydroxy-6-methyl-oxan-2-yl]oxy-8-(5-dimethylamino-6-methyl-oxan-2-yl)oxy-14-hydroxy-13-methoxy-2,9-dimethyl-16-oxo-1-oxacyclohexadeca-4,6-dien-11-yl]acetaldehyde Pharmagrade Spiramycin,Formacidine SpiraMycin API SpiraMycin(SpiraMycin base) SpiraMycin 0.1 foromacidine 5337r.p. antibiotic799 nsc-64393 r.p.5337 rovamycine 2-[(4R,6S,7R,9R,10R,11E,13E,16R)-6-[[5-[(4,5-dihydroxy-4,6-dimethyl-2-oxanyl)oxy]-4-(dimethylamino)-3-hydroxy-6-methyl-2-oxanyl]oxy]-10-[[5-(dimethylamino)-6-methyl-2-oxanyl]oxy]-4-hydroxy-5-methoxy-9 Spiramycin Solution, 1000ppm Spiramycin, >=3900 IU/mg Spiramycin CRS Spiramycin> foromacidin spiramycin Spiramycin USP/EP/BP Spiramycin (S1100000) *Spiramycin*Q: What is *Spiramycin* Q: What is the CAS Number of *Spiramycin* Q: What is the storage condition of *Spiramycin* Q: What are the applications of *Spiramycin* 3-Dihydrobenzofuranyl-5-acetic acid LEUCOMYCIN KITASAMYCIN BASE Spiramycine espiramicin Spiramycin Ep High purity spiramycin Dopamine Impurity 60 8025-81-8 C40H67NO14 C43H74N2O14 BioChemical Antibiotics Antibiotics A to Z Antibiotics N-S Pharmaceutical intermediates Inhibitors Peptide Synthesis/Antibiotics Miscellaneous Natural Products Antibacterial Antibiotics for Research and Experimental Use Biochemistry Macrolides (Antibiotics for Research and Experimental Use) Macrolides MacrolidesAntibiotics